Potentiation of immunosuppressive efficacy by combining the novel leflunomide analog, HMR 279, with microemulsion cyclosporine in a rat lung transplant model

The novel leflunomide (LFM) analog, HMR 279, potentiates the immunosuppressive efficacy of microemulsion cyclosporine (Neoral) in rodent heart transplantation. The present study was designed to evaluate the immunosuppressive efficacy of this combination in comparison to the combination of Neoral and...

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Veröffentlicht in:	Transplantation 1999-02, Vol.67 (3), p.354-359
Hauptverfasser:	HAUSEN, B, BOEKE, K, BERRY, G. J, GUMMERT, J. F, CHRISTIANS, U, MORRIS, R. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemistry Amides - pharmacokinetics Amides - therapeutic use Aniline Compounds - pharmacokinetics Animals Biological and medical sciences Biotransformation Body Weight - drug effects Chromatography, High Pressure Liquid Cyclosporine - administration & dosage Cyclosporine - pharmacokinetics Cyclosporine - therapeutic use Drug Therapy, Combination Emulsions Hydroxybutyrates - pharmacokinetics Immunomodulators Immunosuppressive Agents - pharmacokinetics Immunosuppressive Agents - therapeutic use Isoxazoles - chemistry Leflunomide Lung Transplantation - immunology Male Medical sciences Nitriles - chemistry Nitriles - pharmacokinetics Nitriles - therapeutic use Pharmacology. Drug treatments Rats Rats, Inbred BN Rats, Inbred Lew Structure-Activity Relationship
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