Cell-Surface Expression and Alloantigenic Function of a Human Nonclassical Class I Molecule (HLA-E) in Transgenic Mice

We have introduced the gene (E*01033) encoding the heavy chain of the human nonclassical MHC class I Ag, HLA-E, into the mouse genome. Two founder mice carry a 21-kb fragment, the others bear an 8-kb fragment. Each of the founder mice was mated to mice of an already established C57BL/10 transgenic l...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 1999-05, Vol.162 (9), p.5190-5196
Hauptverfasser:	Pacasova, Rita, Martinozzi, Silvia, Boulouis, Henri-Jean, Ulbrecht, Matthias, Vieville, Jean-Claude, Sigaux, Francois, Weiss, Elisabeth H, Pla, Marika
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta 2-Microglobulin - physiology Cell Membrane - immunology Cell Membrane - metabolism Cells, Cultured Cytotoxicity Tests, Immunologic Cytotoxicity, Immunologic - genetics Female Flow Cytometry Genetic Vectors - chemical synthesis Genetic Vectors - immunology Histocompatibility Antigens Class I - biosynthesis Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - immunology HLA Antigens - biosynthesis HLA Antigens - genetics HLA Antigens - immunology HLA-B27 Antigen - genetics HLA-E Antigens Humans Isoantigens - genetics Isoantigens - physiology Lymph Nodes - cytology Lymph Nodes - immunology Lymphocyte Activation - genetics Mice Mice, Inbred C57BL Mice, Transgenic - immunology Skin Transplantation - immunology T-Lymphocytes, Cytotoxic - immunology Transgenes - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!