Synergism between insecticides permethrin and propoxur occurs through activation of presynaptic muscarinic negative feedback of acetylcholine release in the insect central nervous system

Although synergism between pesticides has been widely documented, the physiological mechanisms by which an insecticide synergizes another remains unclear. Toxicological and electrophysiological studies were carried out on two susceptible pest species (the mosquito Culex quinquefasciatus and the cock...

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Veröffentlicht in:	Neurotoxicology (Park Forest South) 2006-07, Vol.27 (4), p.508-519
Hauptverfasser:	Corbel, Vincent, Stankiewicz, Maria, Bonnet, Julien, Grolleau, Françoise, Hougard, Jean Marc, Lapied, Bruno
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine Acetylcholine - metabolism Animals Central Nervous System - drug effects Cockroaches Culex quinquefasciatus Dose-Response Relationship, Drug Drug Synergism Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Feedback - drug effects Feedback mechanism Ganglia, Invertebrate - cytology Ganglia, Invertebrate - drug effects In Vitro Techniques Insecticide Insecticides - toxicity Larva Lethal Dose 50 Male Models, Biological Mosquitoes Periplaneta americana Permethrin - toxicity Presynaptic Terminals - drug effects Propoxur - toxicity Pyrethroid-carbamate mixture Receptors, Muscarinic - physiology Synaptic transmission Synergism Time Factors
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