The Type of DNA Glycosylase Determines the Base Excision Repair Pathway in Mammalian Cells

The base excision repair (BER) of modified nucleotides is initiated by damage-specific DNA glycosylases. The repair of the resulting apurinic/apyrimidinic site involves the replacement of either a single nucleotide (short patch BER) or of several nucleotides (long patch BER). The mechanism that cont...

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Veröffentlicht in:	The Journal of biological chemistry 1999-05, Vol.274 (21), p.15230-15236
Hauptverfasser:	Fortini, Paola, Parlanti, Eleonora, Sidorkina, Olga M., Laval, Jacques, Dogliotti, Eugenia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - metabolism Animals Base Sequence Cells, Cultured DNA Glycosylases DNA Repair - genetics Guanine - analogs & derivatives Guanine - metabolism HeLa Cells Humans Hypoxanthine - metabolism Mice N-Glycosyl Hydrolases - genetics
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