Skin Necrosis of the Nose After Injection of Ribose Cross-Linked Porcine Atelocollagen
We report a case of skin necrosis of the nasal tip after an injection of ribose cross-linked porcine atelocollagen (Evolence; Colbar Life Science Ltd, Herzliya, Israel). A 22-year-old woman had a nasal augmentation. From the glabella to the nasal tip, 10 strokes were injected using 0.6 mL of Evolenc...
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| Veröffentlicht in: | The Journal of craniofacial surgery 2015-10, Vol.26 (7), p.2211-2212 |
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| container_title | The Journal of craniofacial surgery |
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| creator | Kim, Seong Kee Kim, Joo Ho Hwang, Kun |
| description | We report a case of skin necrosis of the nasal tip after an injection of ribose cross-linked porcine atelocollagen (Evolence; Colbar Life Science Ltd, Herzliya, Israel). A 22-year-old woman had a nasal augmentation. From the glabella to the nasal tip, 10 strokes were injected using 0.6 mL of Evolence. On the day of the injection, her nasal tip became cyanotic; a day after it, an erythematous condition developed and a white cheeselike material appeared. On the second day, it became necrotic. Epithelialization was completed for 2 weeks. Despite laser therapy, permanent scarring of the nasal tip was prominent at the 18-month follow-up. It was thought that the skin necrosis is caused by vascular interruption rather than by hypersensitivity because the skin necrosis was confined to the nasal tip. To avoid vascular interruption from a filler injection, aspiration is needed before injection. The least amount of filler should be released in each stroke with low-pressure injection. |
| doi_str_mv | 10.1097/SCS.0000000000000341 |
| format | Article |
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A 22-year-old woman had a nasal augmentation. From the glabella to the nasal tip, 10 strokes were injected using 0.6 mL of Evolence. On the day of the injection, her nasal tip became cyanotic; a day after it, an erythematous condition developed and a white cheeselike material appeared. On the second day, it became necrotic. Epithelialization was completed for 2 weeks. Despite laser therapy, permanent scarring of the nasal tip was prominent at the 18-month follow-up. It was thought that the skin necrosis is caused by vascular interruption rather than by hypersensitivity because the skin necrosis was confined to the nasal tip. To avoid vascular interruption from a filler injection, aspiration is needed before injection. The least amount of filler should be released in each stroke with low-pressure injection.</description><identifier>ISSN: 1049-2275</identifier><identifier>EISSN: 1536-3732</identifier><identifier>DOI: 10.1097/SCS.0000000000000341</identifier><identifier>PMID: 26468812</identifier><language>eng</language><publisher>United States</publisher><subject>Cicatrix - etiology ; Cicatrix - surgery ; Collagen - adverse effects ; Collagen - chemistry ; Cosmetic Techniques - adverse effects ; Cross-Linking Reagents - chemistry ; Cyanosis - etiology ; Dentistry ; Dermal Fillers - adverse effects ; Dermal Fillers - chemistry ; Erythema - etiology ; Female ; Follow-Up Studies ; Humans ; Injections - adverse effects ; Laser Therapy ; Necrosis ; Nose - pathology ; Re-Epithelialization - physiology ; Ribose - chemistry ; Skin - pathology ; Young Adult</subject><ispartof>The Journal of craniofacial surgery, 2015-10, Vol.26 (7), p.2211-2212</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c307t-8a89a4f8c3e8921d868e41f22d82031d1d2d326b88094730dde436f88a1bca583</citedby><cites>FETCH-LOGICAL-c307t-8a89a4f8c3e8921d868e41f22d82031d1d2d326b88094730dde436f88a1bca583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26468812$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Seong Kee</creatorcontrib><creatorcontrib>Kim, Joo Ho</creatorcontrib><creatorcontrib>Hwang, Kun</creatorcontrib><title>Skin Necrosis of the Nose After Injection of Ribose Cross-Linked Porcine Atelocollagen</title><title>The Journal of craniofacial surgery</title><addtitle>J Craniofac Surg</addtitle><description>We report a case of skin necrosis of the nasal tip after an injection of ribose cross-linked porcine atelocollagen (Evolence; Colbar Life Science Ltd, Herzliya, Israel). A 22-year-old woman had a nasal augmentation. From the glabella to the nasal tip, 10 strokes were injected using 0.6 mL of Evolence. On the day of the injection, her nasal tip became cyanotic; a day after it, an erythematous condition developed and a white cheeselike material appeared. On the second day, it became necrotic. Epithelialization was completed for 2 weeks. Despite laser therapy, permanent scarring of the nasal tip was prominent at the 18-month follow-up. It was thought that the skin necrosis is caused by vascular interruption rather than by hypersensitivity because the skin necrosis was confined to the nasal tip. To avoid vascular interruption from a filler injection, aspiration is needed before injection. The least amount of filler should be released in each stroke with low-pressure injection.</description><subject>Cicatrix - etiology</subject><subject>Cicatrix - surgery</subject><subject>Collagen - adverse effects</subject><subject>Collagen - chemistry</subject><subject>Cosmetic Techniques - adverse effects</subject><subject>Cross-Linking Reagents - chemistry</subject><subject>Cyanosis - etiology</subject><subject>Dentistry</subject><subject>Dermal Fillers - adverse effects</subject><subject>Dermal Fillers - chemistry</subject><subject>Erythema - etiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Injections - adverse effects</subject><subject>Laser Therapy</subject><subject>Necrosis</subject><subject>Nose - pathology</subject><subject>Re-Epithelialization - physiology</subject><subject>Ribose - chemistry</subject><subject>Skin - pathology</subject><subject>Young Adult</subject><issn>1049-2275</issn><issn>1536-3732</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkMtOwzAQRS0EoqXwBwhlySbFHjvJZFlVPCpVBVFgGyX2BNymcYnTBX9PohaEmM2MdM-8LmOXgo8FT5Ob5XQ55n9DKnHEhiKScSgTCcddzVUaAiTRgJ15v-IchID4lA0gVjGigCF7W65tHSxIN85bH7gyaD8oWDhPwaRsqQlm9Yp0a13da8-26JVpB_twbus1meDJNdrWHd5S5bSrqvyd6nN2UuaVp4tDHrHXu9uX6UM4f7yfTSfzUEuetCHmmOaqRC0JUxAGYyQlSgCDwKUwwoCREBeIPFWJ5MaQknGJmItC5xHKEbvez9027nNHvs021mvqjqjJ7XwmEoBUSsCoQ9Ue7V_1DZXZtrGbvPnKBM96R7PO0ey_o13b1WHDrtiQ-W36sVB-A_22b8g</recordid><startdate>20151001</startdate><enddate>20151001</enddate><creator>Kim, Seong Kee</creator><creator>Kim, Joo Ho</creator><creator>Hwang, Kun</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20151001</creationdate><title>Skin Necrosis of the Nose After Injection of Ribose Cross-Linked Porcine Atelocollagen</title><author>Kim, Seong Kee ; Kim, Joo Ho ; Hwang, Kun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c307t-8a89a4f8c3e8921d868e41f22d82031d1d2d326b88094730dde436f88a1bca583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Cicatrix - etiology</topic><topic>Cicatrix - surgery</topic><topic>Collagen - adverse effects</topic><topic>Collagen - chemistry</topic><topic>Cosmetic Techniques - adverse effects</topic><topic>Cross-Linking Reagents - chemistry</topic><topic>Cyanosis - etiology</topic><topic>Dentistry</topic><topic>Dermal Fillers - adverse effects</topic><topic>Dermal Fillers - chemistry</topic><topic>Erythema - etiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Injections - adverse effects</topic><topic>Laser Therapy</topic><topic>Necrosis</topic><topic>Nose - pathology</topic><topic>Re-Epithelialization - physiology</topic><topic>Ribose - chemistry</topic><topic>Skin - pathology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Seong Kee</creatorcontrib><creatorcontrib>Kim, Joo Ho</creatorcontrib><creatorcontrib>Hwang, Kun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of craniofacial surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Seong Kee</au><au>Kim, Joo Ho</au><au>Hwang, Kun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Skin Necrosis of the Nose After Injection of Ribose Cross-Linked Porcine Atelocollagen</atitle><jtitle>The Journal of craniofacial surgery</jtitle><addtitle>J Craniofac Surg</addtitle><date>2015-10-01</date><risdate>2015</risdate><volume>26</volume><issue>7</issue><spage>2211</spage><epage>2212</epage><pages>2211-2212</pages><issn>1049-2275</issn><eissn>1536-3732</eissn><abstract>We report a case of skin necrosis of the nasal tip after an injection of ribose cross-linked porcine atelocollagen (Evolence; Colbar Life Science Ltd, Herzliya, Israel). A 22-year-old woman had a nasal augmentation. From the glabella to the nasal tip, 10 strokes were injected using 0.6 mL of Evolence. On the day of the injection, her nasal tip became cyanotic; a day after it, an erythematous condition developed and a white cheeselike material appeared. On the second day, it became necrotic. Epithelialization was completed for 2 weeks. Despite laser therapy, permanent scarring of the nasal tip was prominent at the 18-month follow-up. It was thought that the skin necrosis is caused by vascular interruption rather than by hypersensitivity because the skin necrosis was confined to the nasal tip. To avoid vascular interruption from a filler injection, aspiration is needed before injection. The least amount of filler should be released in each stroke with low-pressure injection.</abstract><cop>United States</cop><pmid>26468812</pmid><doi>10.1097/SCS.0000000000000341</doi><tpages>2</tpages></addata></record> |
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| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Cicatrix - etiology Cicatrix - surgery Collagen - adverse effects Collagen - chemistry Cosmetic Techniques - adverse effects Cross-Linking Reagents - chemistry Cyanosis - etiology Dentistry Dermal Fillers - adverse effects Dermal Fillers - chemistry Erythema - etiology Female Follow-Up Studies Humans Injections - adverse effects Laser Therapy Necrosis Nose - pathology Re-Epithelialization - physiology Ribose - chemistry Skin - pathology Young Adult |
| title | Skin Necrosis of the Nose After Injection of Ribose Cross-Linked Porcine Atelocollagen |
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