Nerve growth factor–induced synapse-like structures in contralateral sensory ganglia contribute to chronic mirror-image pain

Elevated nerve growth factor (NGF) in the contralateral dorsal root ganglion (DRG) mediates mirror-image pain after peripheral nerve injury, but the underlying mechanism remains unclear. Using intrathecal injection of NGF antibodies, we found that NGF is required for the development of intra-DRG syn...

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Veröffentlicht in:	Pain (Amsterdam) 2015-11, Vol.156 (11), p.2295-2309
Hauptverfasser:	Cheng, Chau-Fu, Cheng, Jen-Kun, Chen, Chih-Yang, Rau, Ruey-Horng, Chang, Yu-Cheng, Tsaur, Meei-Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Disks Large Homolog 4 Protein Functional Laterality - physiology Ganglia, Spinal - drug effects Ganglia, Spinal - metabolism Gene Expression Regulation - physiology Hyperalgesia - etiology Hyperalgesia - metabolism Intracellular Signaling Peptides and Proteins - metabolism Luminescent Proteins - genetics Luminescent Proteins - metabolism Male Membrane Proteins - metabolism Nerve Growth Factor - metabolism Nerve Tissue Proteins - metabolism Neuralgia - complications Neuralgia - metabolism Neuralgia - pathology Neurites - pathology Rats Rats, Sprague-Dawley RNA, Small Interfering - metabolism Shal Potassium Channels - genetics Shal Potassium Channels - metabolism Spinal Puncture Transfection Tyrosine 3-Monooxygenase - metabolism
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