Nucleic acid-based drugs against emerging zoonotic viruses
Global outbreaks of diseases caused by zoonotic viruses have steadily increased in recent years. Emerging zoonotic viruses are generally phylogenetically diverse, are unpredictable and are known to cause diseases with high case fatality rates in humans and are hard to protect against due to lack of...
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| Veröffentlicht in: | Future medicinal chemistry 2015-01, Vol.7 (13), p.1709-1719 |
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| creator | Wong, Jonathan P |
| description | Global outbreaks of diseases caused by zoonotic viruses have steadily increased in recent years. Emerging zoonotic viruses are generally phylogenetically diverse, are unpredictable and are known to cause diseases with high case fatality rates in humans and are hard to protect against due to lack of approved antiviral drugs. The aim of this review is to discuss how advances in genomics, rational drug design and innate immune signaling can contribute to the design of nucleic acid-based drugs to combat these emerging threats. Specifically, the antiviral activity of siRNAs, antisense oligonucleotides is mediated by sequence-specific gene silencing, and broad-spectrum innate and antiviral immune responses can be elicited by toll-like receptor agonists. This review will summarize their current state of development, safety and efficacy, and provide perspectives on future development. |
| doi_str_mv | 10.4155/fmc.15.112 |
| format | Article |
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Emerging zoonotic viruses are generally phylogenetically diverse, are unpredictable and are known to cause diseases with high case fatality rates in humans and are hard to protect against due to lack of approved antiviral drugs. The aim of this review is to discuss how advances in genomics, rational drug design and innate immune signaling can contribute to the design of nucleic acid-based drugs to combat these emerging threats. Specifically, the antiviral activity of siRNAs, antisense oligonucleotides is mediated by sequence-specific gene silencing, and broad-spectrum innate and antiviral immune responses can be elicited by toll-like receptor agonists. This review will summarize their current state of development, safety and efficacy, and provide perspectives on future development.</description><subject>Animals</subject><subject>Antiviral Agents - chemistry</subject><subject>Antiviral Agents - pharmacology</subject><subject>Antiviral Agents - therapeutic use</subject><subject>Drug Discovery - methods</subject><subject>Genomics - methods</subject><subject>Humans</subject><subject>Immunity, Innate - drug effects</subject><subject>Nucleic Acids - chemistry</subject><subject>Nucleic Acids - pharmacology</subject><subject>Nucleic Acids - therapeutic use</subject><subject>Oligonucleotides, Antisense - chemistry</subject><subject>Oligonucleotides, Antisense - pharmacology</subject><subject>Oligonucleotides, Antisense - therapeutic use</subject><subject>RNA, Small Interfering - chemistry</subject><subject>RNA, Small Interfering - pharmacology</subject><subject>RNA, Small Interfering - therapeutic use</subject><subject>RNAi Therapeutics - methods</subject><subject>Virus Diseases - 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immunology</topic><topic>Zoonoses - drug therapy</topic><topic>Zoonoses - immunology</topic><topic>Zoonoses - therapy</topic><topic>Zoonoses - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wong, Jonathan P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Future medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wong, Jonathan P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nucleic acid-based drugs against emerging zoonotic viruses</atitle><jtitle>Future medicinal chemistry</jtitle><addtitle>Future Med Chem</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>7</volume><issue>13</issue><spage>1709</spage><epage>1719</epage><pages>1709-1719</pages><issn>1756-8919</issn><eissn>1756-8927</eissn><abstract>Global outbreaks of diseases caused by zoonotic viruses have steadily increased in recent years. 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| subjects | Animals Antiviral Agents - chemistry Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Drug Discovery - methods Genomics - methods Humans Immunity, Innate - drug effects Nucleic Acids - chemistry Nucleic Acids - pharmacology Nucleic Acids - therapeutic use Oligonucleotides, Antisense - chemistry Oligonucleotides, Antisense - pharmacology Oligonucleotides, Antisense - therapeutic use RNA, Small Interfering - chemistry RNA, Small Interfering - pharmacology RNA, Small Interfering - therapeutic use RNAi Therapeutics - methods Virus Diseases - drug therapy Virus Diseases - immunology Virus Diseases - therapy Virus Diseases - virology Viruses - drug effects Viruses - genetics Viruses - immunology Zoonoses - drug therapy Zoonoses - immunology Zoonoses - therapy Zoonoses - virology |
| title | Nucleic acid-based drugs against emerging zoonotic viruses |
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