The use of Argus® II retinal prosthesis by blind subjects to achieve localisation and prehension of objects in 3-dimensional space
Background The Argus® II retinal prosthesis system has entered mainstream treatment for patients blind from Retinitis Pigmentosa (RP). We set out to evaluate the use of this system by blind subjects to achieve object localisation and prehension in 3-dimensional space. Methods This is a single-centre...
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| Veröffentlicht in: | Graefe's archive for clinical and experimental ophthalmology 2015-11, Vol.253 (11), p.1907-1914 |
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| container_title | Graefe's archive for clinical and experimental ophthalmology |
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| creator | Luo, Yvonne Hsu-Lin Zhong, Joe Jianjiang da Cruz, Lyndon |
| description | Background
The Argus® II retinal prosthesis system has entered mainstream treatment for patients blind from Retinitis Pigmentosa (RP). We set out to evaluate the use of this system by blind subjects to achieve object localisation and prehension in 3-dimensional space.
Methods
This is a single-centre, prospective, internally-controlled case series involving 5 blind RP subjects who received the Argus® II implant. The subjects were instructed to visually locate, reach and grasp (i.e. prehension) a small white cuboid object placed at random locations on a black worktop. A flashing LED beacon was attached to the reaching index finger (as a finger marker) to assess the effect of enhanced finger visualisation on performance. Tasks were performed with the prosthesis switched “on” or “off” and with the finger marker switched “on” or “off”. Forty-eight trials were performed per subject. Trajectory of each subject’s hand movement during the task was recorded by a 3D motion-capture unit (Qualysis®, see
supplementary video
) and analysed using a MATLAB script.
Result
Percentage of successful prehension±standard deviation was: 71.3 ± 27.1 % with prosthesis on and finger marker on; 77.5 ± 24.5 % with prosthesis on and finger marker off; 0.0 ± 0.0 % with prosthesis off and finger marker on, and 0.00 ± 0.00 % with prosthesis off and finger marker off. The finger marker did not have a significant effect on performance (
P =
0.546 and 1, Wilcoxon Signed Rank test, with prosthesis on and off respectively). With prosthesis off, none of the subjects were able to visually locate the target object and no initiation of prehension was attempted. With prosthesis on, prehension was initiated on 82.5 % (range 59–100 %) of the trials with 89.0 % (range 66.7–100 %) achieving successful prehension.
Conclusion
Argus® II subjects were able to achieve object localisation and prehension better with their prosthesis switched on than off. |
| doi_str_mv | 10.1007/s00417-014-2912-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1722930133</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1722930133</sourcerecordid><originalsourceid>FETCH-LOGICAL-c357z-57da859a51f66c40ac4a229528eac3f7adf446e824e0dfc4b2db38e7054b74683</originalsourceid><addsrcrecordid>eNp1kctq3DAUhkVpSSZpHiCbIOimG6W6Wp5lCGkzEMgmheyELB9nNHjsqY4dmNnmffoQfbJq8DSUQFZCnO__dPkJORf8UnBuvyHnWljGhWZyLiTbfSAzoZVhlsvHj2TGrRSsVPLxmJwgrnjGlRFH5Fgao20hyhl5eVgCHRFo39Cr9DTin990saAJhtj5lm5Sj8MSMCKttrRqY1dTHKsVhAHp0FMflhGegbZ98G1EP8S-oz5DmwRL6HC_zeb-kIgdVayO62mS_bjxAT6TT41vEc4O6yn5-f3m4fqW3d3_WFxf3bGgjN0xY2tfmrk3oimKoLkP2ks5N7IEH1Rjfd1oXUApNfC6CbqSdaVKsNzoyuqiVKfk6-TNr_o1Ag5uHTFA2_oO-hGdsFmnuFAqo1_eoKt-TPnGE6VMwQ3PlJiokL8JEzRuk-Lap60T3O0bclNDLjfk9g25Xc5cHMxjtYb6NfGvkgzICcA86p4g_Xf0u9a_sL-d2w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1722356050</pqid></control><display><type>article</type><title>The use of Argus® II retinal prosthesis by blind subjects to achieve localisation and prehension of objects in 3-dimensional space</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Luo, Yvonne Hsu-Lin ; Zhong, Joe Jianjiang ; da Cruz, Lyndon</creator><creatorcontrib>Luo, Yvonne Hsu-Lin ; Zhong, Joe Jianjiang ; da Cruz, Lyndon</creatorcontrib><description>Background
The Argus® II retinal prosthesis system has entered mainstream treatment for patients blind from Retinitis Pigmentosa (RP). We set out to evaluate the use of this system by blind subjects to achieve object localisation and prehension in 3-dimensional space.
Methods
This is a single-centre, prospective, internally-controlled case series involving 5 blind RP subjects who received the Argus® II implant. The subjects were instructed to visually locate, reach and grasp (i.e. prehension) a small white cuboid object placed at random locations on a black worktop. A flashing LED beacon was attached to the reaching index finger (as a finger marker) to assess the effect of enhanced finger visualisation on performance. Tasks were performed with the prosthesis switched “on” or “off” and with the finger marker switched “on” or “off”. Forty-eight trials were performed per subject. Trajectory of each subject’s hand movement during the task was recorded by a 3D motion-capture unit (Qualysis®, see
supplementary video
) and analysed using a MATLAB script.
Result
Percentage of successful prehension±standard deviation was: 71.3 ± 27.1 % with prosthesis on and finger marker on; 77.5 ± 24.5 % with prosthesis on and finger marker off; 0.0 ± 0.0 % with prosthesis off and finger marker on, and 0.00 ± 0.00 % with prosthesis off and finger marker off. The finger marker did not have a significant effect on performance (
P =
0.546 and 1, Wilcoxon Signed Rank test, with prosthesis on and off respectively). With prosthesis off, none of the subjects were able to visually locate the target object and no initiation of prehension was attempted. With prosthesis on, prehension was initiated on 82.5 % (range 59–100 %) of the trials with 89.0 % (range 66.7–100 %) achieving successful prehension.
Conclusion
Argus® II subjects were able to achieve object localisation and prehension better with their prosthesis switched on than off.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/s00417-014-2912-z</identifier><identifier>PMID: 25547618</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Blindness - physiopathology ; Blindness - rehabilitation ; Female ; Humans ; Imaging, Three-Dimensional ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Ophthalmology ; Pattern Recognition, Visual - physiology ; Proprioception - physiology ; Prospective Studies ; Prosthesis Implantation ; Psychomotor Performance - physiology ; Psychophysiology ; Retina - physiopathology ; Retinal Disorders ; Retinitis Pigmentosa - physiopathology ; Retinitis Pigmentosa - rehabilitation ; Visual Prosthesis</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 2015-11, Vol.253 (11), p.1907-1914</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><rights>Springer-Verlag Berlin Heidelberg 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357z-57da859a51f66c40ac4a229528eac3f7adf446e824e0dfc4b2db38e7054b74683</citedby><cites>FETCH-LOGICAL-c357z-57da859a51f66c40ac4a229528eac3f7adf446e824e0dfc4b2db38e7054b74683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00417-014-2912-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00417-014-2912-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25547618$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luo, Yvonne Hsu-Lin</creatorcontrib><creatorcontrib>Zhong, Joe Jianjiang</creatorcontrib><creatorcontrib>da Cruz, Lyndon</creatorcontrib><title>The use of Argus® II retinal prosthesis by blind subjects to achieve localisation and prehension of objects in 3-dimensional space</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>Background
The Argus® II retinal prosthesis system has entered mainstream treatment for patients blind from Retinitis Pigmentosa (RP). We set out to evaluate the use of this system by blind subjects to achieve object localisation and prehension in 3-dimensional space.
Methods
This is a single-centre, prospective, internally-controlled case series involving 5 blind RP subjects who received the Argus® II implant. The subjects were instructed to visually locate, reach and grasp (i.e. prehension) a small white cuboid object placed at random locations on a black worktop. A flashing LED beacon was attached to the reaching index finger (as a finger marker) to assess the effect of enhanced finger visualisation on performance. Tasks were performed with the prosthesis switched “on” or “off” and with the finger marker switched “on” or “off”. Forty-eight trials were performed per subject. Trajectory of each subject’s hand movement during the task was recorded by a 3D motion-capture unit (Qualysis®, see
supplementary video
) and analysed using a MATLAB script.
Result
Percentage of successful prehension±standard deviation was: 71.3 ± 27.1 % with prosthesis on and finger marker on; 77.5 ± 24.5 % with prosthesis on and finger marker off; 0.0 ± 0.0 % with prosthesis off and finger marker on, and 0.00 ± 0.00 % with prosthesis off and finger marker off. The finger marker did not have a significant effect on performance (
P =
0.546 and 1, Wilcoxon Signed Rank test, with prosthesis on and off respectively). With prosthesis off, none of the subjects were able to visually locate the target object and no initiation of prehension was attempted. With prosthesis on, prehension was initiated on 82.5 % (range 59–100 %) of the trials with 89.0 % (range 66.7–100 %) achieving successful prehension.
Conclusion
Argus® II subjects were able to achieve object localisation and prehension better with their prosthesis switched on than off.</description><subject>Aged</subject><subject>Blindness - physiopathology</subject><subject>Blindness - rehabilitation</subject><subject>Female</subject><subject>Humans</subject><subject>Imaging, Three-Dimensional</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Ophthalmology</subject><subject>Pattern Recognition, Visual - physiology</subject><subject>Proprioception - physiology</subject><subject>Prospective Studies</subject><subject>Prosthesis Implantation</subject><subject>Psychomotor Performance - physiology</subject><subject>Psychophysiology</subject><subject>Retina - physiopathology</subject><subject>Retinal Disorders</subject><subject>Retinitis Pigmentosa - physiopathology</subject><subject>Retinitis Pigmentosa - rehabilitation</subject><subject>Visual Prosthesis</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kctq3DAUhkVpSSZpHiCbIOimG6W6Wp5lCGkzEMgmheyELB9nNHjsqY4dmNnmffoQfbJq8DSUQFZCnO__dPkJORf8UnBuvyHnWljGhWZyLiTbfSAzoZVhlsvHj2TGrRSsVPLxmJwgrnjGlRFH5Fgao20hyhl5eVgCHRFo39Cr9DTin990saAJhtj5lm5Sj8MSMCKttrRqY1dTHKsVhAHp0FMflhGegbZ98G1EP8S-oz5DmwRL6HC_zeb-kIgdVayO62mS_bjxAT6TT41vEc4O6yn5-f3m4fqW3d3_WFxf3bGgjN0xY2tfmrk3oimKoLkP2ks5N7IEH1Rjfd1oXUApNfC6CbqSdaVKsNzoyuqiVKfk6-TNr_o1Ag5uHTFA2_oO-hGdsFmnuFAqo1_eoKt-TPnGE6VMwQ3PlJiokL8JEzRuk-Lap60T3O0bclNDLjfk9g25Xc5cHMxjtYb6NfGvkgzICcA86p4g_Xf0u9a_sL-d2w</recordid><startdate>20151101</startdate><enddate>20151101</enddate><creator>Luo, Yvonne Hsu-Lin</creator><creator>Zhong, Joe Jianjiang</creator><creator>da Cruz, Lyndon</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20151101</creationdate><title>The use of Argus® II retinal prosthesis by blind subjects to achieve localisation and prehension of objects in 3-dimensional space</title><author>Luo, Yvonne Hsu-Lin ; Zhong, Joe Jianjiang ; da Cruz, Lyndon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357z-57da859a51f66c40ac4a229528eac3f7adf446e824e0dfc4b2db38e7054b74683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Blindness - physiopathology</topic><topic>Blindness - rehabilitation</topic><topic>Female</topic><topic>Humans</topic><topic>Imaging, Three-Dimensional</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Ophthalmology</topic><topic>Pattern Recognition, Visual - physiology</topic><topic>Proprioception - physiology</topic><topic>Prospective Studies</topic><topic>Prosthesis Implantation</topic><topic>Psychomotor Performance - physiology</topic><topic>Psychophysiology</topic><topic>Retina - physiopathology</topic><topic>Retinal Disorders</topic><topic>Retinitis Pigmentosa - physiopathology</topic><topic>Retinitis Pigmentosa - rehabilitation</topic><topic>Visual Prosthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luo, Yvonne Hsu-Lin</creatorcontrib><creatorcontrib>Zhong, Joe Jianjiang</creatorcontrib><creatorcontrib>da Cruz, Lyndon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luo, Yvonne Hsu-Lin</au><au>Zhong, Joe Jianjiang</au><au>da Cruz, Lyndon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The use of Argus® II retinal prosthesis by blind subjects to achieve localisation and prehension of objects in 3-dimensional space</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><stitle>Graefes Arch Clin Exp Ophthalmol</stitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><date>2015-11-01</date><risdate>2015</risdate><volume>253</volume><issue>11</issue><spage>1907</spage><epage>1914</epage><pages>1907-1914</pages><issn>0721-832X</issn><eissn>1435-702X</eissn><abstract>Background
The Argus® II retinal prosthesis system has entered mainstream treatment for patients blind from Retinitis Pigmentosa (RP). We set out to evaluate the use of this system by blind subjects to achieve object localisation and prehension in 3-dimensional space.
Methods
This is a single-centre, prospective, internally-controlled case series involving 5 blind RP subjects who received the Argus® II implant. The subjects were instructed to visually locate, reach and grasp (i.e. prehension) a small white cuboid object placed at random locations on a black worktop. A flashing LED beacon was attached to the reaching index finger (as a finger marker) to assess the effect of enhanced finger visualisation on performance. Tasks were performed with the prosthesis switched “on” or “off” and with the finger marker switched “on” or “off”. Forty-eight trials were performed per subject. Trajectory of each subject’s hand movement during the task was recorded by a 3D motion-capture unit (Qualysis®, see
supplementary video
) and analysed using a MATLAB script.
Result
Percentage of successful prehension±standard deviation was: 71.3 ± 27.1 % with prosthesis on and finger marker on; 77.5 ± 24.5 % with prosthesis on and finger marker off; 0.0 ± 0.0 % with prosthesis off and finger marker on, and 0.00 ± 0.00 % with prosthesis off and finger marker off. The finger marker did not have a significant effect on performance (
P =
0.546 and 1, Wilcoxon Signed Rank test, with prosthesis on and off respectively). With prosthesis off, none of the subjects were able to visually locate the target object and no initiation of prehension was attempted. With prosthesis on, prehension was initiated on 82.5 % (range 59–100 %) of the trials with 89.0 % (range 66.7–100 %) achieving successful prehension.
Conclusion
Argus® II subjects were able to achieve object localisation and prehension better with their prosthesis switched on than off.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25547618</pmid><doi>10.1007/s00417-014-2912-z</doi><tpages>8</tpages></addata></record> |
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| issn | 0721-832X 1435-702X |
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| subjects | Aged Blindness - physiopathology Blindness - rehabilitation Female Humans Imaging, Three-Dimensional Male Medicine Medicine & Public Health Middle Aged Ophthalmology Pattern Recognition, Visual - physiology Proprioception - physiology Prospective Studies Prosthesis Implantation Psychomotor Performance - physiology Psychophysiology Retina - physiopathology Retinal Disorders Retinitis Pigmentosa - physiopathology Retinitis Pigmentosa - rehabilitation Visual Prosthesis |
| title | The use of Argus® II retinal prosthesis by blind subjects to achieve localisation and prehension of objects in 3-dimensional space |
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