Xenoestrogens Ethinyl Estradiol and Zearalenone Cause Precocious Puberty in Female Rats via Central Kisspeptin Signaling

Xenoestrogens from synthetic or natural origin represent an increasing risk of disrupted endocrine functions including the physiological activity of the hypothalamo-pituitary-gonad axis. Ethinyl estradiol (EE2) is a synthetic estrogen used in contraceptive pills, whereas zearalenone (ZEA) is a natur...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2015-11, Vol.156 (11), p.3996-4007
Hauptverfasser:	Kriszt, Rókus, Winkler, Zsuzsanna, Polyák, Ágnes, Kuti, Dániel, Molnár, Csilla, Hrabovszky, Erik, Kalló, Imre, Szőke, Zsuzsanna, Ferenczi, Szilamér, Kovács, Krisztina J
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Animals Arcuate nucleus Arcuate Nucleus of Hypothalamus - drug effects Arcuate Nucleus of Hypothalamus - metabolism Cereal crops Contraceptives Estrogen receptors Estrogens Estrogens - pharmacology Estrogens, Non-Steroidal - pharmacology Ethinyl Estradiol - pharmacology Ethinylestradiol Female Females Follicles Gene expression Gene Expression - drug effects Gonadotropin-releasing hormone Gonadotropin-Releasing Hormone - genetics Gonadotropin-Releasing Hormone - metabolism Gonadotropins Gonadotropins - metabolism Histochemistry Hybridization Hypothalamus Hypothalamus - cytology Hypothalamus - drug effects Hypothalamus - metabolism In Situ Hybridization Kiss1 protein Kisspeptins - genetics Kisspeptins - metabolism Microscopy, Confocal Neuroendocrine system Neurons - drug effects Neurons - metabolism Ovulation Pituitary Pituitary (anterior) Preoptic area Puberty Rats, Wistar Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Receptors, Kisspeptin-1 Reproductive system Reverse Transcriptase Polymerase Chain Reaction Sex hormones Sexual Maturation - drug effects Signal Transduction - drug effects Signal Transduction - genetics Uterus Uterus - drug effects Uterus - growth & development Uterus - metabolism Vagina Xenobiotics - pharmacology Xenoestrogens Zearalenone Zearalenone - pharmacology
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