Comparison of the efficacy of chlorhexidine gluconate versus povidone iodine as preoperative skin preparation for the prevention of surgical site infections in clean-contaminated upper abdominal surgeries
Purpose To compare the efficacy of chlorhexidine-gluconate versus povidone iodine in preoperative skin preparation in the prevention of surgical site infections (SSIs) in clean-contaminated upper abdominal surgeries. Methods This was a prospective randomized controlled trial conducted on patients un...
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| Veröffentlicht in: | Surgery today (Tokyo, Japan) Japan), 2015-11, Vol.45 (11), p.1378-1384 |
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| creator | Srinivas, Anirudh Kaman, Lileswar Raj, Prithivi Gautam, Vikas Dahiya, Divya Singh, Gurpreet Singh, Rajinder Medhi, Bikash |
| description | Purpose
To compare the efficacy of chlorhexidine-gluconate versus povidone iodine in preoperative skin preparation in the prevention of surgical site infections (SSIs) in clean-contaminated upper abdominal surgeries.
Methods
This was a prospective randomized controlled trial conducted on patients undergoing clean-contaminated upper abdominal surgeries. A total of 351 patients 18–70 years old were randomized into two groups; chlorhexidine and povidone iodine skin preparation before surgery.
Results
The incidence of SSIs in the chlorhexidine group was 10.8 %, in comparison to 17.9 % in the povidone iodine group. The odds ratio was 0.6 in favor of chlorhexidine use, but the results were not statistically significant (
P
= 0.06). In the first postoperative week, SSIs developed in 7 % of patients in the chlorhexidine group and 14.1 % in the povidone iodine group (
P
= 0.03), and in the second postoperative week, SSIs were present in 4.1 % of the patients in the chlorhexidine group and 4.4 % in the povidone iodine group, which was not statistically significant (
P
= 0.88).
Conclusions
The incidence of SSIs after clean-contaminated upper abdominal surgeries was lower with the use of chlorhexidine skin preparation than with povidone iodine preparation, although the results were not statistically significant. However, the odds ratio between the two groups favored the use of chlorhexidine over povidone iodine for preventing SSIs. |
| doi_str_mv | 10.1007/s00595-014-1078-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1722925034</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1722925034</sourcerecordid><originalsourceid>FETCH-LOGICAL-c504t-addc0845ad96ea1416c00aeca3af924bb21336b9e580beb37e27436e231a8e653</originalsourceid><addsrcrecordid>eNp9kcuO1DAQRS0EYnoGPoAN8pKNB7_yWqIWA0gjsYG15TiVaQ9JHFxJi_5HPopK98CSle1bt-rIdRl7o-StkrJ6j1IWTSGkskLJqhanZ2ynrCmFrpV5znaysUoo3agrdo34KKW2tZQv2ZUuTK1sXe7Y730aZ58jpomnni8H4ND3Mfhw2t7hMKR8gF-xixPwh2ENafIL8CNkXJHP6Ri7RJWYzgZPUoY0Q_ZLPALHH3HaFCKQQIg-5TODtCNMZ4kouOYHQg4cI82OUw9hKyFdeRjAT4Kwix_jxu74OhOA-7ZLmzKc2yFHwFfsRe8HhNdP5w37fvfx2_6zuP_66cv-w70IhbSL8F0XZG0L3zUleGVVGaT0ELzxfaNt22plTNk2UNSyhdZUoCvaKmijfA1lYW7Yu8vcOaefK-DixogBhsFPkFZ0qtK60YU0lqzqYg05IWbo3Zzj6PPJKem2EN0lREchui1Ed6Ket0_j13aE7l_H39TIoC8GpNJEf3ePac20CvzP1D_ZKq9K</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1722925034</pqid></control><display><type>article</type><title>Comparison of the efficacy of chlorhexidine gluconate versus povidone iodine as preoperative skin preparation for the prevention of surgical site infections in clean-contaminated upper abdominal surgeries</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Srinivas, Anirudh ; Kaman, Lileswar ; Raj, Prithivi ; Gautam, Vikas ; Dahiya, Divya ; Singh, Gurpreet ; Singh, Rajinder ; Medhi, Bikash</creator><creatorcontrib>Srinivas, Anirudh ; Kaman, Lileswar ; Raj, Prithivi ; Gautam, Vikas ; Dahiya, Divya ; Singh, Gurpreet ; Singh, Rajinder ; Medhi, Bikash</creatorcontrib><description>Purpose
To compare the efficacy of chlorhexidine-gluconate versus povidone iodine in preoperative skin preparation in the prevention of surgical site infections (SSIs) in clean-contaminated upper abdominal surgeries.
Methods
This was a prospective randomized controlled trial conducted on patients undergoing clean-contaminated upper abdominal surgeries. A total of 351 patients 18–70 years old were randomized into two groups; chlorhexidine and povidone iodine skin preparation before surgery.
Results
The incidence of SSIs in the chlorhexidine group was 10.8 %, in comparison to 17.9 % in the povidone iodine group. The odds ratio was 0.6 in favor of chlorhexidine use, but the results were not statistically significant (
P
= 0.06). In the first postoperative week, SSIs developed in 7 % of patients in the chlorhexidine group and 14.1 % in the povidone iodine group (
P
= 0.03), and in the second postoperative week, SSIs were present in 4.1 % of the patients in the chlorhexidine group and 4.4 % in the povidone iodine group, which was not statistically significant (
P
= 0.88).
Conclusions
The incidence of SSIs after clean-contaminated upper abdominal surgeries was lower with the use of chlorhexidine skin preparation than with povidone iodine preparation, although the results were not statistically significant. However, the odds ratio between the two groups favored the use of chlorhexidine over povidone iodine for preventing SSIs.</description><identifier>ISSN: 0941-1291</identifier><identifier>EISSN: 1436-2813</identifier><identifier>DOI: 10.1007/s00595-014-1078-y</identifier><identifier>PMID: 25381486</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject><![CDATA[Abdomen - surgery ; Administration, Topical ; Adolescent ; Adult ; Aged ; Anti-Infective Agents, Local - administration & dosage ; Chlorhexidine - administration & dosage ; Chlorhexidine - analogs & derivatives ; Humans ; Incidence ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Article ; Povidone-Iodine - administration & dosage ; Preoperative Care ; Prospective Studies ; Skin - microbiology ; Solutions ; Surgery ; Surgical Oncology ; Surgical Wound Infection - epidemiology ; Surgical Wound Infection - prevention & control ; Young Adult]]></subject><ispartof>Surgery today (Tokyo, Japan), 2015-11, Vol.45 (11), p.1378-1384</ispartof><rights>Springer Japan 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-addc0845ad96ea1416c00aeca3af924bb21336b9e580beb37e27436e231a8e653</citedby><cites>FETCH-LOGICAL-c504t-addc0845ad96ea1416c00aeca3af924bb21336b9e580beb37e27436e231a8e653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00595-014-1078-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00595-014-1078-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25381486$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Srinivas, Anirudh</creatorcontrib><creatorcontrib>Kaman, Lileswar</creatorcontrib><creatorcontrib>Raj, Prithivi</creatorcontrib><creatorcontrib>Gautam, Vikas</creatorcontrib><creatorcontrib>Dahiya, Divya</creatorcontrib><creatorcontrib>Singh, Gurpreet</creatorcontrib><creatorcontrib>Singh, Rajinder</creatorcontrib><creatorcontrib>Medhi, Bikash</creatorcontrib><title>Comparison of the efficacy of chlorhexidine gluconate versus povidone iodine as preoperative skin preparation for the prevention of surgical site infections in clean-contaminated upper abdominal surgeries</title><title>Surgery today (Tokyo, Japan)</title><addtitle>Surg Today</addtitle><addtitle>Surg Today</addtitle><description>Purpose
To compare the efficacy of chlorhexidine-gluconate versus povidone iodine in preoperative skin preparation in the prevention of surgical site infections (SSIs) in clean-contaminated upper abdominal surgeries.
Methods
This was a prospective randomized controlled trial conducted on patients undergoing clean-contaminated upper abdominal surgeries. A total of 351 patients 18–70 years old were randomized into two groups; chlorhexidine and povidone iodine skin preparation before surgery.
Results
The incidence of SSIs in the chlorhexidine group was 10.8 %, in comparison to 17.9 % in the povidone iodine group. The odds ratio was 0.6 in favor of chlorhexidine use, but the results were not statistically significant (
P
= 0.06). In the first postoperative week, SSIs developed in 7 % of patients in the chlorhexidine group and 14.1 % in the povidone iodine group (
P
= 0.03), and in the second postoperative week, SSIs were present in 4.1 % of the patients in the chlorhexidine group and 4.4 % in the povidone iodine group, which was not statistically significant (
P
= 0.88).
Conclusions
The incidence of SSIs after clean-contaminated upper abdominal surgeries was lower with the use of chlorhexidine skin preparation than with povidone iodine preparation, although the results were not statistically significant. However, the odds ratio between the two groups favored the use of chlorhexidine over povidone iodine for preventing SSIs.</description><subject>Abdomen - surgery</subject><subject>Administration, Topical</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anti-Infective Agents, Local - administration & dosage</subject><subject>Chlorhexidine - administration & dosage</subject><subject>Chlorhexidine - analogs & derivatives</subject><subject>Humans</subject><subject>Incidence</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Povidone-Iodine - administration & dosage</subject><subject>Preoperative Care</subject><subject>Prospective Studies</subject><subject>Skin - microbiology</subject><subject>Solutions</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Surgical Wound Infection - epidemiology</subject><subject>Surgical Wound Infection - prevention & control</subject><subject>Young Adult</subject><issn>0941-1291</issn><issn>1436-2813</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcuO1DAQRS0EYnoGPoAN8pKNB7_yWqIWA0gjsYG15TiVaQ9JHFxJi_5HPopK98CSle1bt-rIdRl7o-StkrJ6j1IWTSGkskLJqhanZ2ynrCmFrpV5znaysUoo3agrdo34KKW2tZQv2ZUuTK1sXe7Y730aZ58jpomnni8H4ND3Mfhw2t7hMKR8gF-xixPwh2ENafIL8CNkXJHP6Ri7RJWYzgZPUoY0Q_ZLPALHH3HaFCKQQIg-5TODtCNMZ4kouOYHQg4cI82OUw9hKyFdeRjAT4Kwix_jxu74OhOA-7ZLmzKc2yFHwFfsRe8HhNdP5w37fvfx2_6zuP_66cv-w70IhbSL8F0XZG0L3zUleGVVGaT0ELzxfaNt22plTNk2UNSyhdZUoCvaKmijfA1lYW7Yu8vcOaefK-DixogBhsFPkFZ0qtK60YU0lqzqYg05IWbo3Zzj6PPJKem2EN0lREchui1Ed6Ket0_j13aE7l_H39TIoC8GpNJEf3ePac20CvzP1D_ZKq9K</recordid><startdate>20151101</startdate><enddate>20151101</enddate><creator>Srinivas, Anirudh</creator><creator>Kaman, Lileswar</creator><creator>Raj, Prithivi</creator><creator>Gautam, Vikas</creator><creator>Dahiya, Divya</creator><creator>Singh, Gurpreet</creator><creator>Singh, Rajinder</creator><creator>Medhi, Bikash</creator><general>Springer Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20151101</creationdate><title>Comparison of the efficacy of chlorhexidine gluconate versus povidone iodine as preoperative skin preparation for the prevention of surgical site infections in clean-contaminated upper abdominal surgeries</title><author>Srinivas, Anirudh ; Kaman, Lileswar ; Raj, Prithivi ; Gautam, Vikas ; Dahiya, Divya ; Singh, Gurpreet ; Singh, Rajinder ; Medhi, Bikash</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-addc0845ad96ea1416c00aeca3af924bb21336b9e580beb37e27436e231a8e653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Abdomen - surgery</topic><topic>Administration, Topical</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anti-Infective Agents, Local - administration & dosage</topic><topic>Chlorhexidine - administration & dosage</topic><topic>Chlorhexidine - analogs & derivatives</topic><topic>Humans</topic><topic>Incidence</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Povidone-Iodine - administration & dosage</topic><topic>Preoperative Care</topic><topic>Prospective Studies</topic><topic>Skin - microbiology</topic><topic>Solutions</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Surgical Wound Infection - epidemiology</topic><topic>Surgical Wound Infection - prevention & control</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Srinivas, Anirudh</creatorcontrib><creatorcontrib>Kaman, Lileswar</creatorcontrib><creatorcontrib>Raj, Prithivi</creatorcontrib><creatorcontrib>Gautam, Vikas</creatorcontrib><creatorcontrib>Dahiya, Divya</creatorcontrib><creatorcontrib>Singh, Gurpreet</creatorcontrib><creatorcontrib>Singh, Rajinder</creatorcontrib><creatorcontrib>Medhi, Bikash</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery today (Tokyo, Japan)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Srinivas, Anirudh</au><au>Kaman, Lileswar</au><au>Raj, Prithivi</au><au>Gautam, Vikas</au><au>Dahiya, Divya</au><au>Singh, Gurpreet</au><au>Singh, Rajinder</au><au>Medhi, Bikash</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of the efficacy of chlorhexidine gluconate versus povidone iodine as preoperative skin preparation for the prevention of surgical site infections in clean-contaminated upper abdominal surgeries</atitle><jtitle>Surgery today (Tokyo, Japan)</jtitle><stitle>Surg Today</stitle><addtitle>Surg Today</addtitle><date>2015-11-01</date><risdate>2015</risdate><volume>45</volume><issue>11</issue><spage>1378</spage><epage>1384</epage><pages>1378-1384</pages><issn>0941-1291</issn><eissn>1436-2813</eissn><abstract>Purpose
To compare the efficacy of chlorhexidine-gluconate versus povidone iodine in preoperative skin preparation in the prevention of surgical site infections (SSIs) in clean-contaminated upper abdominal surgeries.
Methods
This was a prospective randomized controlled trial conducted on patients undergoing clean-contaminated upper abdominal surgeries. A total of 351 patients 18–70 years old were randomized into two groups; chlorhexidine and povidone iodine skin preparation before surgery.
Results
The incidence of SSIs in the chlorhexidine group was 10.8 %, in comparison to 17.9 % in the povidone iodine group. The odds ratio was 0.6 in favor of chlorhexidine use, but the results were not statistically significant (
P
= 0.06). In the first postoperative week, SSIs developed in 7 % of patients in the chlorhexidine group and 14.1 % in the povidone iodine group (
P
= 0.03), and in the second postoperative week, SSIs were present in 4.1 % of the patients in the chlorhexidine group and 4.4 % in the povidone iodine group, which was not statistically significant (
P
= 0.88).
Conclusions
The incidence of SSIs after clean-contaminated upper abdominal surgeries was lower with the use of chlorhexidine skin preparation than with povidone iodine preparation, although the results were not statistically significant. However, the odds ratio between the two groups favored the use of chlorhexidine over povidone iodine for preventing SSIs.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>25381486</pmid><doi>10.1007/s00595-014-1078-y</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0941-1291 |
| ispartof | Surgery today (Tokyo, Japan), 2015-11, Vol.45 (11), p.1378-1384 |
| issn | 0941-1291 1436-2813 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1722925034 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Abdomen - surgery Administration, Topical Adolescent Adult Aged Anti-Infective Agents, Local - administration & dosage Chlorhexidine - administration & dosage Chlorhexidine - analogs & derivatives Humans Incidence Medicine Medicine & Public Health Middle Aged Original Article Povidone-Iodine - administration & dosage Preoperative Care Prospective Studies Skin - microbiology Solutions Surgery Surgical Oncology Surgical Wound Infection - epidemiology Surgical Wound Infection - prevention & control Young Adult |
| title | Comparison of the efficacy of chlorhexidine gluconate versus povidone iodine as preoperative skin preparation for the prevention of surgical site infections in clean-contaminated upper abdominal surgeries |
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