Continuous manufacturing of extended release tablets via powder mixing and direct compression

[Display omitted] The aim of the current work was to explore continuous dry powder mixing and direct compression for manufacturing of extended release (ER) matrix tablets. The study was span out with a challenging formulation design comprising ibuprofen compositions with varying particle size and a...

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Veröffentlicht in:	International journal of pharmaceutics 2015-11, Vol.495 (1), p.290-301
Hauptverfasser:	Ervasti, Tuomas, Simonaho, Simo-Pekka, Ketolainen, Jarkko, Forsberg, Peter, Fransson, Magnus, Wikström, Håkan, Folestad, Staffan, Lakio, Satu, Tajarobi, Pirjo, Abrahmsén-Alami, Susanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive control Continuous manufacturing Continuous mixing Delayed-Action Preparations - chemistry Direct compression Drug Industry - methods Drug Liberation Extended release HPMC Hypromellose Derivatives - chemistry Ibuprofen - chemistry Particle Size Powders - chemistry Solubility Tablets - chemistry Technology, Pharmaceutical - methods Tensile Strength
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