Two-Component Domino Reactions Initiated from Ketenes: Serendipitous Synthesis of Quinolizidinones Analogous to Chelated Lobeline’s Conformation

An original and efficient synthesis of quinolizidinones through a one-pot two-component cascade reaction of norlobelanine with in situ generated ketenes is reported. Functionalized fused azabicyclic scaffolds bearing multiple stereogenic centers were prepared with excellent diastereoselectivities. M...

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Veröffentlicht in:	Journal of organic chemistry 2015-10, Vol.80 (20), p.10119-10126
Hauptverfasser:	Drège, Emmanuelle, Venot, Pierre-Etienne, Le Bideau, Franck, Retailleau, Pascal, Joseph, Delphine
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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