Friedel–Crafts Hydroxyalkylation of Indoles Mediated by Trimethylsilyl Trifluoromethanesulfonate

Indoles and N-alkylindoles undergo Friedel–Crafts addition to aldehydes in the presence of trimethylsilyl trifluoromethanesulfonate and a trialkylamine to produce 3-(1-silyloxyalkyl)­indoles. Neutralization of the reaction mixture with pyridine followed by deprotection under basic conditions with te...

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Veröffentlicht in:	Journal of organic chemistry 2015-10, Vol.80 (20), p.10364-10369
Hauptverfasser:	Downey, C. Wade, Poff, Christopher D, Nizinski, Alissa N
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes - chemistry Catalysis Indoles - chemistry Mesylates - chemistry Molecular Structure Thermodynamics Trimethylsilyl Compounds - chemistry
Online-Zugang:	Volltext
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