Pivotal Role of Mitochondrial Calcium Uptake in Neural Cell Apoptosis and Necrosis

: Perturbed cellular calcium homeostasis has been implicated in both apoptosis and necrosis, but the role of altered mitochondrial calcium handling in the cell death process is unclear. The temporal ordering of changes in cytoplasmic ([Ca2+]C) and intramitochondrial ([Ca2+]M) calcium levels in relat...

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Veröffentlicht in:	Journal of neurochemistry 1999-02, Vol.72 (2), p.529-540
Hauptverfasser:	Kruman, Inna I., Mattson, Mark P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Chloromethyl Ketones - pharmacology Animals Apoptosis - drug effects Apoptosis - physiology Bcl‐2 Biological and medical sciences Calcium - metabolism Caspase Caspase 3 Caspase Inhibitors Caspases - metabolism Cell physiology Cysteine Proteinase Inhibitors - pharmacology Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Membrane and intracellular transports Membrane depolarization Membrane Potentials - physiology Mitochondria - enzymology Molecular and cellular biology Necrosis Neurons - cytology Neurons - metabolism Neurons - pathology Oligopeptides - pharmacology PC12 Cells Proto-Oncogene Proteins c-bcl-2 - metabolism Rats Reactive oxygen species Reactive Oxygen Species - metabolism Staurosporine Staurosporine - pharmacology
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