Characterization of the Batl (Bacteroides aerotolerance) operon in Bacteroides fragilis: isolation of a B. fragilis mutant with reduced aerotolerance and impaired growth in in vivo model systems

YT135.2.8, a Tn4400' insertion mutant of Bacteroides fragilis strain TM4000, grows poorly when used to infect Monika or Chinese hamster ovary (CHO) cell monolayers and is outcompeted by wild-type strains in mixed infections. YT135.2.8 also shows defects in the rat granuloma pouch model system i...

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Veröffentlicht in:	Molecular microbiology 1999-04, Vol.32 (1), p.139-149
Hauptverfasser:	Tang, Y P, Dallas, M M, Malamy, M H
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Bacteroides fragilis Bacteroides fragilis - genetics Cricetinae DNA Transposable Elements Granuloma - microbiology Mice Microbiological Techniques Models, Genetic Molecular Sequence Data Mutagenesis, Insertional Operon Oxygen - adverse effects Oxygen - metabolism Plasmids Rats Reducing Agents - pharmacology Sequence Analysis, DNA Sequence Homology, Amino Acid Time Factors
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