Ascorbic acid and α-tocopherol as potent modulators of apoptosis on arsenic induced toxicity in rats

Apoptosis or programmed cell death (PCD) is a genetically regulated cellular, physiological and biochemical suicidal mechanism that plays a crucial role in the development and defense of homeostasis, in which the cell participates in its own demise via a cascade of molecular interactions. PCD can be...

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Veröffentlicht in:	Toxicology letters 2005-04, Vol.156 (2), p.297-306
Hauptverfasser:	Ramanathan, Kadirvel, Anusuyadevi, Muthuswamy, Shila, Samuel, Panneerselvam, Chinnakannu
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Tocopherol - pharmacology Animals Antioxidants - pharmacology Apoptosis Apoptosis - drug effects Arsenic Arsenites - toxicity Ascorbic Acid - pharmacology Biological and medical sciences Caspase 3 Caspases - metabolism Chemical and industrial products toxicology. Toxic occupational diseases DNA Damage DNA fragmentation Environmental Pollutants - toxicity In Situ Nick-End Labeling Kidney - metabolism Leukocytes - metabolism Liver - metabolism Male Medical sciences Metals and various inorganic compounds Rats Rats, Wistar Sodium Compounds - toxicity TNF-α Toxicology Tumor Necrosis Factor-alpha - metabolism Vitamin C Vitamin E
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