Diabetogenic effects and pancreatic oxidative damage in rats subchronically exposed to arsenite

Recent epidemiologic studies have associated chronic inorganic arsenic ( iAs) exposure with an increase in the prevalence of diabetes mellitus. Currently, the diabetogenic mechanism caused by iAs exposure is unclear. However, it is recognized that iAs contributes to oxidative stress in several organ...

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Veröffentlicht in:	Toxicology letters 2006-01, Vol.160 (2), p.135-142
Hauptverfasser:	Izquierdo-Vega, Jeannett A., Soto, Claudia A., Sanchez-Peña, Luz C., Vizcaya-Ruiz, Andrea De, Razo, Luz M. Del
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arsenic Arsenic metabolism Arsenites - pharmacokinetics Arsenites - toxicity Biological and medical sciences Blood Glucose - analysis Chemical and industrial products toxicology. Toxic occupational diseases Diabetes mellitus Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Enzyme Inhibitors - pharmacokinetics Enzyme Inhibitors - toxicity Etiopathogenesis. Screening. Investigations. Target tissue resistance Glucagon - blood Glutathione - metabolism Immunohistochemistry Insulin Resistance Lipid Peroxidation Male Medical sciences Metals and various inorganic compounds Models, Animal Oxidative Stress Pancreas - chemistry Pancreas - drug effects Pancreas - metabolism Rats Rats, Wistar Sodium Compounds - pharmacokinetics Sodium Compounds - toxicity Thioredoxin-Disulfide Reductase - metabolism Toxicology
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