Effects of an Allergy-Associated Mutation in the Human IL-4R alpha (Q576R) on Human IL-4-Induced Signal Transduction

A mutation in the human (hu) IL-4R alpha , Q576R, has been linked with allergy in humans. Increased sensitivity of patients cells with this mutation to IL-4 suggest that a Q576R change enhances IL-4 signaling. To directly test this hypothesis, we analyzed the ability of huIL-4R alpha cDNA bearing th...

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Veröffentlicht in:	The Journal of immunology (1950) 1999-04, Vol.162 (8), p.4385-4389
Hauptverfasser:	Wang, HY, Shelburne, C P, Zamorano, J, Kelly, A E, Ryan, J J, Keegan, AD
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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