DNA Vaccination Against the Idiotype of a Murine B Cell Lymphoma: Mechanism of Tumor Protection

Several studies have shown that immunization with DNA, which encodes the idiotypic determinants of a B cell lymphoma, generates tumor-specific immunity. Although induction of antiidiotypic Abs has correlated with tumor protection, the effector mechanisms that contribute to tumor protection have not...

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Veröffentlicht in:	The Journal of immunology (1950) 1999-04, Vol.162 (8), p.4790-4795
Hauptverfasser:	Syrengelas, Athanasia D, Levy, Ronald
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Antibodies, Anti-Idiotypic - biosynthesis Cytotoxicity Tests, Immunologic Female Granulocyte-Macrophage Colony-Stimulating Factor - genetics Granulocyte-Macrophage Colony-Stimulating Factor - immunology Immunity, Cellular - genetics Immunoglobulin Idiotypes - genetics Immunoglobulin Idiotypes - immunology Lymphocyte Transfusion Lymphoma, B-Cell - genetics Lymphoma, B-Cell - immunology Lymphoma, B-Cell - prevention & control Mice Mice, Inbred C3H Recombinant Fusion Proteins - administration & dosage Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology Tumor Cells, Cultured Vaccines, DNA - genetics Vaccines, DNA - immunology
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