Diamine oxidase, a plasma biomarker in rats to GI tract toxicity of oral fluorouracil anti-cancer drugs

Diamine oxidase (DAO; EC 1.4.3.6), which catabolizes a variety of substrates including histamine and diamines, is the degradative enzyme of the catabolic pathway of polyamines found in high activity in the mature upper villus cells of the rat intestinal mucosa [Luk, G.D., Bayless, T.M., Baylin, S.B....

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Veröffentlicht in:	Toxicology (Amsterdam) 2006-01, Vol.217 (2), p.233-239
Hauptverfasser:	Moriyama, Kenji, Kouchi, Yasuhide, Morinaga, Hidenobu, Irimura, Kenji, Hayashi, Taiji, Ohuchida, Akinobu, Goto, Tetsuhiro, Yoshizawa, Yasuo
Format:	Artikel
Sprache:	eng
Schlagworte:	5-FU Administration, Oral Amine Oxidase (Copper-Containing) - blood Animals Antimetabolites, Antineoplastic - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use Apoptosis - drug effects Biological and medical sciences Biomarkers - blood Body Weight - drug effects Diamine oxidase Dihydrouracil Dehydrogenase (NADP) - antagonists & inhibitors Fluorouracil - administration & dosage Fluorouracil - toxicity GI tract toxicity Intestinal Mucosa - drug effects Intestinal Mucosa - pathology Jejunal Diseases - blood Jejunal Diseases - chemically induced Jejunal Diseases - drug therapy Male Medical sciences Orotate Phosphoribosyltransferase - antagonists & inhibitors Otorhinolaryngology. Stomatology Oxonic Acid - administration & dosage Pyridines - administration & dosage Pyridines - toxicity Rat Rats Rats, Sprague-Dawley Tegafur - administration & dosage Tegafur - toxicity Toxicology Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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