ALK and ROS1 rearrangements tested by fluorescence in situ hybridization in cytological smears from advanced non-small cell lung cancer patients
Background The identification of ALK and ROS1 rearrangements and the availability of an effective target therapy, such as crizotinib, represent a new option in the treatment of advanced non‐small cell lung cancer (NSCLC) patients. In light of recent advances in non‐invasive diagnostic procedures, we...
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| Veröffentlicht in: | Diagnostic cytopathology 2015-11, Vol.43 (11), p.941-946 |
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| creator | Bozzetti, Cecilia Nizzoli, Rita Tiseo, Marcello Squadrilli, Anna Lagrasta, Costanza Buti, Sebastiano Gasparro, Donatello Zanoni, Daniele Majori, Maria De Filippo, Massimo Mazzoni, Francesca Maddau, Cristina Naldi, Nadia Sammarelli, Gabriella Frati, Caterina Pinto, Carmine Ardizzoni, Andrea |
| description | Background
The identification of ALK and ROS1 rearrangements and the availability of an effective target therapy, such as crizotinib, represent a new option in the treatment of advanced non‐small cell lung cancer (NSCLC) patients. In light of recent advances in non‐invasive diagnostic procedures, we aimed to demonstrate that direct cytological smears are suitable for assessing ALK and ROS1 rearrangements in patients with NSCLC.
Methods
Fifty‐five patients with a cytological diagnosis of lung adenocarcinoma (ADC) were evaluated for ALK rearrangements by fluorescence in situ hybridization (FISH) and 12 patients for ROS1 FISH rearrangements. Seventeen of the 55 cytological samples tested for ALK were obtained from the primary tumor and 38 from metastatic lesions. Ten of 12 samples evaluated for ROS1 were obtained from metastatic sites and two from the primary tumor.
Results
ALK FISH was successful in 49/55 (89%) cytological ADC samples and ROS1 FISH in all 12 cytological samples. ALK rearrangements were found in 3/13 (23%) primary tumors and 7/36 (19%) metastatic sites. ROS1 rearrangements were found in one of the two primary tumors and in two of the 10 metastases. Two of the three rearranged cases were tested on cytology after knowing that they were rearranged on histology in order to increase representativeness of ROS1 rearranged cases in this study.
Conclusion
Whenever cytology represents the only available material for diagnosis and biological characterization of NSCLC, minimally invasive procedures may provide an additional important source of cellular material for FISH assessment of ALK and ROS1 rearrangements./// Diagn. Cytopathol. 2015;43:941–946. © 2015 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/dc.23318 |
| format | Article |
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The identification of ALK and ROS1 rearrangements and the availability of an effective target therapy, such as crizotinib, represent a new option in the treatment of advanced non‐small cell lung cancer (NSCLC) patients. In light of recent advances in non‐invasive diagnostic procedures, we aimed to demonstrate that direct cytological smears are suitable for assessing ALK and ROS1 rearrangements in patients with NSCLC.
Methods
Fifty‐five patients with a cytological diagnosis of lung adenocarcinoma (ADC) were evaluated for ALK rearrangements by fluorescence in situ hybridization (FISH) and 12 patients for ROS1 FISH rearrangements. Seventeen of the 55 cytological samples tested for ALK were obtained from the primary tumor and 38 from metastatic lesions. Ten of 12 samples evaluated for ROS1 were obtained from metastatic sites and two from the primary tumor.
Results
ALK FISH was successful in 49/55 (89%) cytological ADC samples and ROS1 FISH in all 12 cytological samples. ALK rearrangements were found in 3/13 (23%) primary tumors and 7/36 (19%) metastatic sites. ROS1 rearrangements were found in one of the two primary tumors and in two of the 10 metastases. Two of the three rearranged cases were tested on cytology after knowing that they were rearranged on histology in order to increase representativeness of ROS1 rearranged cases in this study.
Conclusion
Whenever cytology represents the only available material for diagnosis and biological characterization of NSCLC, minimally invasive procedures may provide an additional important source of cellular material for FISH assessment of ALK and ROS1 rearrangements./// Diagn. Cytopathol. 2015;43:941–946. © 2015 Wiley Periodicals, Inc.</description><identifier>ISSN: 8755-1039</identifier><identifier>EISSN: 1097-0339</identifier><identifier>DOI: 10.1002/dc.23318</identifier><identifier>PMID: 26152804</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adenocarcinoma - diagnosis ; Adenocarcinoma - pathology ; Adenocarcinoma of Lung ; Adult ; Aged ; Aged, 80 and over ; ALK ; Anaplastic Lymphoma Kinase ; Carcinoma, Non-Small-Cell Lung - metabolism ; Carcinoma, Non-Small-Cell Lung - surgery ; Cytodiagnosis - methods ; cytology ; Female ; FISH ; Gene Rearrangement - physiology ; Humans ; In Situ Hybridization, Fluorescence - methods ; Lung cancer ; Lung Neoplasms - diagnosis ; Lung Neoplasms - metabolism ; Lung Neoplasms - pathology ; Lung Neoplasms - surgery ; Male ; Middle Aged ; non-small cell lung cancer ; Protein-Tyrosine Kinases - metabolism ; Proto-Oncogene Proteins - metabolism ; Receptor Protein-Tyrosine Kinases - metabolism ; ROS1</subject><ispartof>Diagnostic cytopathology, 2015-11, Vol.43 (11), p.941-946</ispartof><rights>2015 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4578-e0d399c5a4dd349732218efae3d8d1fc135420ef50a22657e4de434190bfeffd3</citedby><cites>FETCH-LOGICAL-c4578-e0d399c5a4dd349732218efae3d8d1fc135420ef50a22657e4de434190bfeffd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fdc.23318$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fdc.23318$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26152804$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bozzetti, Cecilia</creatorcontrib><creatorcontrib>Nizzoli, Rita</creatorcontrib><creatorcontrib>Tiseo, Marcello</creatorcontrib><creatorcontrib>Squadrilli, Anna</creatorcontrib><creatorcontrib>Lagrasta, Costanza</creatorcontrib><creatorcontrib>Buti, Sebastiano</creatorcontrib><creatorcontrib>Gasparro, Donatello</creatorcontrib><creatorcontrib>Zanoni, Daniele</creatorcontrib><creatorcontrib>Majori, Maria</creatorcontrib><creatorcontrib>De Filippo, Massimo</creatorcontrib><creatorcontrib>Mazzoni, Francesca</creatorcontrib><creatorcontrib>Maddau, Cristina</creatorcontrib><creatorcontrib>Naldi, Nadia</creatorcontrib><creatorcontrib>Sammarelli, Gabriella</creatorcontrib><creatorcontrib>Frati, Caterina</creatorcontrib><creatorcontrib>Pinto, Carmine</creatorcontrib><creatorcontrib>Ardizzoni, Andrea</creatorcontrib><title>ALK and ROS1 rearrangements tested by fluorescence in situ hybridization in cytological smears from advanced non-small cell lung cancer patients</title><title>Diagnostic cytopathology</title><addtitle>Diagn. Cytopathol</addtitle><description>Background
The identification of ALK and ROS1 rearrangements and the availability of an effective target therapy, such as crizotinib, represent a new option in the treatment of advanced non‐small cell lung cancer (NSCLC) patients. In light of recent advances in non‐invasive diagnostic procedures, we aimed to demonstrate that direct cytological smears are suitable for assessing ALK and ROS1 rearrangements in patients with NSCLC.
Methods
Fifty‐five patients with a cytological diagnosis of lung adenocarcinoma (ADC) were evaluated for ALK rearrangements by fluorescence in situ hybridization (FISH) and 12 patients for ROS1 FISH rearrangements. Seventeen of the 55 cytological samples tested for ALK were obtained from the primary tumor and 38 from metastatic lesions. Ten of 12 samples evaluated for ROS1 were obtained from metastatic sites and two from the primary tumor.
Results
ALK FISH was successful in 49/55 (89%) cytological ADC samples and ROS1 FISH in all 12 cytological samples. ALK rearrangements were found in 3/13 (23%) primary tumors and 7/36 (19%) metastatic sites. ROS1 rearrangements were found in one of the two primary tumors and in two of the 10 metastases. Two of the three rearranged cases were tested on cytology after knowing that they were rearranged on histology in order to increase representativeness of ROS1 rearranged cases in this study.
Conclusion
Whenever cytology represents the only available material for diagnosis and biological characterization of NSCLC, minimally invasive procedures may provide an additional important source of cellular material for FISH assessment of ALK and ROS1 rearrangements./// Diagn. Cytopathol. 2015;43:941–946. © 2015 Wiley Periodicals, Inc.</description><subject>Adenocarcinoma - diagnosis</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma of Lung</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>ALK</subject><subject>Anaplastic Lymphoma Kinase</subject><subject>Carcinoma, Non-Small-Cell Lung - metabolism</subject><subject>Carcinoma, Non-Small-Cell Lung - surgery</subject><subject>Cytodiagnosis - methods</subject><subject>cytology</subject><subject>Female</subject><subject>FISH</subject><subject>Gene Rearrangement - physiology</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence - methods</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Lung Neoplasms - metabolism</subject><subject>Lung Neoplasms - pathology</subject><subject>Lung Neoplasms - surgery</subject><subject>Male</subject><subject>Middle Aged</subject><subject>non-small cell lung cancer</subject><subject>Protein-Tyrosine Kinases - metabolism</subject><subject>Proto-Oncogene Proteins - metabolism</subject><subject>Receptor Protein-Tyrosine Kinases - metabolism</subject><subject>ROS1</subject><issn>8755-1039</issn><issn>1097-0339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kV1rFDEUhoModq2Cv0AC3ngzNV-zmblsV90VFwt-gjchm5ysqTPJmsy0rr_Cn2zGbisIEjiBnCdPTngRekzJCSWEPbfmhHFOmztoRkkrK8J5exfNGlnXFSW8PUIPcr4ghLSMzu-jIzanNWuImKFfp-s3WAeL352_pziBTkmHLfQQhowHyANYvNlj140xQTYQDGAfcPbDiL_uN8lb_1MPPobp1OyH2MWtN7rDuS-ujF2KPdb2UpeLFocYqtzrrsMGSunGsMVmaiW8K5bp0YfontNdhkeH_Rh9fPXyw2JVrc-Xrxen68qIWjYVEMvb1tRaWMtFKzljtAGngdvGUmcorwUj4GqiGZvXEoQFwQVtycaBc5Yfo2fX3l2K38fyUdX7PE2lA8QxKyoZE2UxWdCn_6AXcUyhTDdRtBFCCvJXaFLMOYFTu-R7nfaKEjWlpKxRf1Iq6JODcNz0YG_Bm1gKUF0DV76D_X9F6sXiRnjgfQnsxy2v0zc1l1zW6vPbpeJnzZez1fKTWvHfEmuq_g</recordid><startdate>201511</startdate><enddate>201511</enddate><creator>Bozzetti, Cecilia</creator><creator>Nizzoli, Rita</creator><creator>Tiseo, Marcello</creator><creator>Squadrilli, Anna</creator><creator>Lagrasta, Costanza</creator><creator>Buti, Sebastiano</creator><creator>Gasparro, Donatello</creator><creator>Zanoni, Daniele</creator><creator>Majori, Maria</creator><creator>De Filippo, Massimo</creator><creator>Mazzoni, Francesca</creator><creator>Maddau, Cristina</creator><creator>Naldi, Nadia</creator><creator>Sammarelli, Gabriella</creator><creator>Frati, Caterina</creator><creator>Pinto, Carmine</creator><creator>Ardizzoni, Andrea</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201511</creationdate><title>ALK and ROS1 rearrangements tested by fluorescence in situ hybridization in cytological smears from advanced non-small cell lung cancer patients</title><author>Bozzetti, Cecilia ; Nizzoli, Rita ; Tiseo, Marcello ; Squadrilli, Anna ; Lagrasta, Costanza ; Buti, Sebastiano ; Gasparro, Donatello ; Zanoni, Daniele ; Majori, Maria ; De Filippo, Massimo ; Mazzoni, Francesca ; Maddau, Cristina ; Naldi, Nadia ; Sammarelli, Gabriella ; Frati, Caterina ; Pinto, Carmine ; Ardizzoni, Andrea</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4578-e0d399c5a4dd349732218efae3d8d1fc135420ef50a22657e4de434190bfeffd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adenocarcinoma - diagnosis</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma of Lung</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>ALK</topic><topic>Anaplastic Lymphoma Kinase</topic><topic>Carcinoma, Non-Small-Cell Lung - metabolism</topic><topic>Carcinoma, Non-Small-Cell Lung - surgery</topic><topic>Cytodiagnosis - methods</topic><topic>cytology</topic><topic>Female</topic><topic>FISH</topic><topic>Gene Rearrangement - physiology</topic><topic>Humans</topic><topic>In Situ Hybridization, Fluorescence - methods</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - diagnosis</topic><topic>Lung Neoplasms - metabolism</topic><topic>Lung Neoplasms - pathology</topic><topic>Lung Neoplasms - surgery</topic><topic>Male</topic><topic>Middle Aged</topic><topic>non-small cell lung cancer</topic><topic>Protein-Tyrosine Kinases - metabolism</topic><topic>Proto-Oncogene Proteins - metabolism</topic><topic>Receptor Protein-Tyrosine Kinases - metabolism</topic><topic>ROS1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bozzetti, Cecilia</creatorcontrib><creatorcontrib>Nizzoli, Rita</creatorcontrib><creatorcontrib>Tiseo, Marcello</creatorcontrib><creatorcontrib>Squadrilli, Anna</creatorcontrib><creatorcontrib>Lagrasta, Costanza</creatorcontrib><creatorcontrib>Buti, Sebastiano</creatorcontrib><creatorcontrib>Gasparro, Donatello</creatorcontrib><creatorcontrib>Zanoni, Daniele</creatorcontrib><creatorcontrib>Majori, Maria</creatorcontrib><creatorcontrib>De Filippo, Massimo</creatorcontrib><creatorcontrib>Mazzoni, Francesca</creatorcontrib><creatorcontrib>Maddau, Cristina</creatorcontrib><creatorcontrib>Naldi, Nadia</creatorcontrib><creatorcontrib>Sammarelli, Gabriella</creatorcontrib><creatorcontrib>Frati, Caterina</creatorcontrib><creatorcontrib>Pinto, Carmine</creatorcontrib><creatorcontrib>Ardizzoni, Andrea</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Diagnostic cytopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bozzetti, Cecilia</au><au>Nizzoli, Rita</au><au>Tiseo, Marcello</au><au>Squadrilli, Anna</au><au>Lagrasta, Costanza</au><au>Buti, Sebastiano</au><au>Gasparro, Donatello</au><au>Zanoni, Daniele</au><au>Majori, Maria</au><au>De Filippo, Massimo</au><au>Mazzoni, Francesca</au><au>Maddau, Cristina</au><au>Naldi, Nadia</au><au>Sammarelli, Gabriella</au><au>Frati, Caterina</au><au>Pinto, Carmine</au><au>Ardizzoni, Andrea</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ALK and ROS1 rearrangements tested by fluorescence in situ hybridization in cytological smears from advanced non-small cell lung cancer patients</atitle><jtitle>Diagnostic cytopathology</jtitle><addtitle>Diagn. Cytopathol</addtitle><date>2015-11</date><risdate>2015</risdate><volume>43</volume><issue>11</issue><spage>941</spage><epage>946</epage><pages>941-946</pages><issn>8755-1039</issn><eissn>1097-0339</eissn><abstract>Background
The identification of ALK and ROS1 rearrangements and the availability of an effective target therapy, such as crizotinib, represent a new option in the treatment of advanced non‐small cell lung cancer (NSCLC) patients. In light of recent advances in non‐invasive diagnostic procedures, we aimed to demonstrate that direct cytological smears are suitable for assessing ALK and ROS1 rearrangements in patients with NSCLC.
Methods
Fifty‐five patients with a cytological diagnosis of lung adenocarcinoma (ADC) were evaluated for ALK rearrangements by fluorescence in situ hybridization (FISH) and 12 patients for ROS1 FISH rearrangements. Seventeen of the 55 cytological samples tested for ALK were obtained from the primary tumor and 38 from metastatic lesions. Ten of 12 samples evaluated for ROS1 were obtained from metastatic sites and two from the primary tumor.
Results
ALK FISH was successful in 49/55 (89%) cytological ADC samples and ROS1 FISH in all 12 cytological samples. ALK rearrangements were found in 3/13 (23%) primary tumors and 7/36 (19%) metastatic sites. ROS1 rearrangements were found in one of the two primary tumors and in two of the 10 metastases. Two of the three rearranged cases were tested on cytology after knowing that they were rearranged on histology in order to increase representativeness of ROS1 rearranged cases in this study.
Conclusion
Whenever cytology represents the only available material for diagnosis and biological characterization of NSCLC, minimally invasive procedures may provide an additional important source of cellular material for FISH assessment of ALK and ROS1 rearrangements./// Diagn. Cytopathol. 2015;43:941–946. © 2015 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>26152804</pmid><doi>10.1002/dc.23318</doi><tpages>6</tpages></addata></record> |
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| subjects | Adenocarcinoma - diagnosis Adenocarcinoma - pathology Adenocarcinoma of Lung Adult Aged Aged, 80 and over ALK Anaplastic Lymphoma Kinase Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - surgery Cytodiagnosis - methods cytology Female FISH Gene Rearrangement - physiology Humans In Situ Hybridization, Fluorescence - methods Lung cancer Lung Neoplasms - diagnosis Lung Neoplasms - metabolism Lung Neoplasms - pathology Lung Neoplasms - surgery Male Middle Aged non-small cell lung cancer Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins - metabolism Receptor Protein-Tyrosine Kinases - metabolism ROS1 |
| title | ALK and ROS1 rearrangements tested by fluorescence in situ hybridization in cytological smears from advanced non-small cell lung cancer patients |
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