Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteins

Many microbes create and maintain pathogen-containing vacuoles (PVs) as an intracellular niche permissive for microbial growth and survival. The destruction of PVs by IFNγ-inducible guanylate binding protein (GBP) and immunity-related GTPase (IRG) host proteins is central to a successful immune resp...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2015-10, Vol.112 (41), p.E5628-E5637
Hauptverfasser:	Haldar, Arun K., Foltz, Clémence, Finethy, Ryan, Piro, Anthony S., Feeley, Eric M., Pilla-Moffett, Danielle M., Komatsu, Masaki, Frickel, Eva-Maria, Coers, Jörn
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding sites Biological Sciences Cells Chlamydia Chlamydia Infections - immunology Chlamydia trachomatis - immunology GTP-Binding Proteins - genetics GTP-Binding Proteins - immunology Immune Evasion Immunity, Innate Mice Mice, Knockout Pathogens PNAS Plus Proteins TNF Receptor-Associated Factor 6 - genetics TNF Receptor-Associated Factor 6 - immunology Toxoplasma - immunology Toxoplasmosis - genetics Toxoplasmosis - immunology Toxoplasmosis - pathology Tumor necrosis factor-TNF Ubiquitin - genetics Ubiquitin - immunology Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - immunology Vacuoles - immunology Vacuoles - metabolism Vacuoles - microbiology
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