Prognostic value of PD-1 and TIM-3 on CD3+ T cells from diffuse large B-cell lymphoma

Abstract Objective To investigate the expression of PD-1 and TIM-3 in CD3+ T cells in patients with diffuse large B-cell lymphoma (DLBCL). Methods A retrospective analysis was conducted on data from 46 patients with newly diagnosed DLBCL and 30 healthy people. Flow cytometry was used to detect the e...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2015-10, Vol.75, p.83-87
Hauptverfasser:	Zhang, Li, Du, Hui, Xiao, Tai-wu, Liu, Ji-zhu, Liu, Guo-zhen, Wang, Jing-xia, Li, Guang-yao, Wang, Le-xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal, Murine-Derived - therapeutic use Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomarkers, Tumor - metabolism CD3 Complex - metabolism Chemotherapy efficiency Cyclophosphamide - therapeutic use Diffuse large B-cell lymphoma Doxorubicin - therapeutic use Female Flow Cytometry Hepatitis A Virus Cellular Receptor 2 Humans Internal Medicine Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - metabolism Lymphoma, Large B-Cell, Diffuse - drug therapy Lymphoma, Large B-Cell, Diffuse - immunology Lymphoma, Large B-Cell, Diffuse - metabolism Lymphoma, Large B-Cell, Diffuse - pathology Male Medical Education Membrane Proteins - metabolism Neoplasm Staging PD-1 Prednisone - therapeutic use Prognosis Programmed Cell Death 1 Receptor - metabolism Retrospective Studies T-Lymphocytes - immunology T-Lymphocytes - metabolism TIM-3 Treatment Outcome Vincristine - therapeutic use
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