Validation of intratracheal instillation as an alternative for aerosol inhalation toxicity testing

In collecting inhalation toxicity data for the evaluation of the health hazard from occupational exposure to the aerosols of a drug or a chemical, the determination of the inhaled dose in relation to the animal response is most desirable. Intratracheal administration is most likely to deliver an exa...

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Veröffentlicht in:	Journal of applied toxicology 1999-03, Vol.19 (2), p.133-140
Hauptverfasser:	Sabaitis, C. P., Leong, B. K. J., Rop, D. A., Aaron, C. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Administration, Intranasal Administration, Oral Aerosols Animals Biological and medical sciences Dose-Response Relationship, Drug Evaluation Studies as Topic General aspects. Methods Hazardous Substances - administration & dosage Hazardous Substances - toxicity ingestion inhalation Injections, Intravenous - methods instillation intratracheal intravenous injection Intubation, Intratracheal - methods Lethal Dose 50 Lung - drug effects Lung - pathology Lung - physiopathology Male Medical sciences nebulization Nebulizers and Vaporizers Rats Rats, Sprague-Dawley Reproducibility of Results Respiratory Sounds - drug effects Respiratory Sounds - physiopathology Toxicity Tests - methods Toxicology
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