Identification of Amino Acids in the N‐Terminal Domain of Corticotropin‐Releasing Factor Receptor 1 that Are Important Determinants of High‐Affinity Ligand Binding

: The aim of the present study was to identify the N‐terminal regions of human corticotropin‐releasing factor (CRF) receptor type 1 (hCRF‐R1) that are crucial for ligand binding. Mutant receptors were constructed by replacing specific residues in hCRF‐R1 with amino acids from the corresponding posit...

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Veröffentlicht in:	Journal of neurochemistry 1999-01, Vol.72 (1), p.388-395
Hauptverfasser:	Wille, Sandra, Sydow, Sabine, Palchaudhuri, Monika R, Spiess, Joachim, Dautzenberg, Frank M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - analysis Animals Binding Sites - physiology Biological and medical sciences Cell receptors Cell structures and functions Cells, Cultured Corticotropin-Releasing Hormone - metabolism Corticotropin-Releasing Hormone - pharmacology Corticotropin‐releasing factor binding site Corticotropin‐releasing factor receptor 1 mutagenesis Cyclic AMP Cyclic AMP - metabolism DNA, Complementary Fundamental and applied biological sciences. Psychology Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors Humans Kidney - cytology Ligand binding Ligands Molecular and cellular biology Molecular Sequence Data Mutagenesis - physiology Neuroprotective Agents - metabolism Neuroprotective Agents - pharmacology Peptide Fragments - metabolism Peptide Fragments - pharmacology Protein Structure, Tertiary Rats Receptors, Corticotropin-Releasing Hormone - chemistry Receptors, Corticotropin-Releasing Hormone - genetics Receptors, Corticotropin-Releasing Hormone - metabolism Sequence Homology, Amino Acid Transfection
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