Integrated in silico and experimental methods revealed that Arctigenin inhibited angiogenesis and HCT116 cell migration and invasion through regulating the H1F4A and Wnt/β-catenin pathway
Arctigenin (ARG) has been previously reported to exert diverse biological activities including anti-proliferation, anti-inflammatory, and antiviral, etc. In the current study, the anti-metastasis and anti-angiogenesis activities of ARG were investigated. To further understand how ARG played these bi...
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| Veröffentlicht in: | Molecular bioSystems 2015-01, Vol.11 (11), p.2878-2884 |
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| container_title | Molecular bioSystems |
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| creator | Zhang, Shouyue Li, Jie Song, Sicheng Li, Jing Tong, Rongsheng Zang, Zhihe Jiang, Qinglin Cai, Lulu |
| description | Arctigenin (ARG) has been previously reported to exert diverse biological activities including anti-proliferation, anti-inflammatory, and antiviral, etc. In the current study, the anti-metastasis and anti-angiogenesis activities of ARG were investigated. To further understand how ARG played these bioactivities, proteomic approaches were used to profile the proteome changes in response to ARG treatment using 2DE-MS/MS. Using these approaches, a total of 50 differentially expressed proteins were identified and clustered. Bioinformatics analysis suggested that multiple signalling pathways were involved. Moreover, ARG induced anti-metastatic and anti-angiogenesis activities were mainly accompanied by a deactivation of the Wnt/β-catenin pathway in HCT116 cells. |
| doi_str_mv | 10.1039/c5mb00439j |
| format | Article |
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Moreover, ARG induced anti-metastatic and anti-angiogenesis activities were mainly accompanied by a deactivation of the Wnt/β-catenin pathway in HCT116 cells.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Animals, Genetically Modified</subject><subject>Cell Movement - drug effects</subject><subject>Cell Proliferation - drug effects</subject><subject>Computational Biology</subject><subject>Computer Simulation</subject><subject>Furans - chemistry</subject><subject>Furans - pharmacology</subject><subject>Furans - therapeutic use</subject><subject>HCT116 Cells</subject><subject>Histones - metabolism</subject><subject>Human Umbilical Vein Endothelial Cells - drug effects</subject><subject>Human Umbilical Vein Endothelial Cells - metabolism</subject><subject>Humans</subject><subject>Lignans - chemistry</subject><subject>Lignans - pharmacology</subject><subject>Lignans - therapeutic use</subject><subject>Molecular Sequence Data</subject><subject>Neoplasm Invasiveness</subject><subject>Neovascularization, Pathologic - drug therapy</subject><subject>Protein Interaction Maps - drug effects</subject><subject>Proteomics</subject><subject>Wnt Signaling Pathway - drug effects</subject><subject>Wound Healing - drug effects</subject><subject>Zebrafish - genetics</subject><issn>1742-206X</issn><issn>1742-2051</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kUtO5DAQQC00CBhgwwFGXo6QAv4kjr1sWjANArEBwS5ykurEKHF6bIfPtVhzBs6E03xWtqueX9lVCB1QckQJV8dV1peEpFw9bKAdmqcsYSSjv3724n4b_fb-gRAuU0q20DYTTOSMqR30dm4DNE4HqLGx2JvOVAPWtsbwvAJnerBBd7iH0A61xw4eQXeRDa0OeOaqYBqw8aKxrSnNZNG2MUMMgjd-LVrMbygVuIIuesxUywx2nTH2UfvpEFo3jE0b9c3YxbxtYgjwgp6lszV5Z8Px-2tSxXdO1VY6tE_6ZQ9tLnXnYf9r3UW3Z6c380Vyef3vfD67TCom85BIXdZ1zbmqSykkgUyzkhOhSsilUpliOVVCyCVTKaOU5SJNiQYpgHMW2ZTvor-f3pUb_o_gQ9EbP_1HWxhGX9DYSyozKUVEDz_Ryg3eO1gWq9hE7V4KSoppWsU8uzpZT-siwn--vGPZQ_2Dfo-HfwCYGJKG</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Zhang, Shouyue</creator><creator>Li, Jie</creator><creator>Song, Sicheng</creator><creator>Li, Jing</creator><creator>Tong, Rongsheng</creator><creator>Zang, Zhihe</creator><creator>Jiang, Qinglin</creator><creator>Cai, Lulu</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150101</creationdate><title>Integrated in silico and experimental methods revealed that Arctigenin inhibited angiogenesis and HCT116 cell migration and invasion through regulating the H1F4A and Wnt/β-catenin pathway</title><author>Zhang, Shouyue ; Li, Jie ; Song, Sicheng ; Li, Jing ; Tong, Rongsheng ; Zang, Zhihe ; Jiang, Qinglin ; Cai, Lulu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c287t-8abddd339db8680e5a2b3069be7899592719668f294211276440ae86e3325a243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Animals, Genetically Modified</topic><topic>Cell Movement - drug effects</topic><topic>Cell Proliferation - drug effects</topic><topic>Computational Biology</topic><topic>Computer Simulation</topic><topic>Furans - chemistry</topic><topic>Furans - pharmacology</topic><topic>Furans - therapeutic use</topic><topic>HCT116 Cells</topic><topic>Histones - metabolism</topic><topic>Human Umbilical Vein Endothelial Cells - drug effects</topic><topic>Human Umbilical Vein Endothelial Cells - metabolism</topic><topic>Humans</topic><topic>Lignans - chemistry</topic><topic>Lignans - pharmacology</topic><topic>Lignans - therapeutic use</topic><topic>Molecular Sequence Data</topic><topic>Neoplasm Invasiveness</topic><topic>Neovascularization, Pathologic - drug therapy</topic><topic>Protein Interaction Maps - drug effects</topic><topic>Proteomics</topic><topic>Wnt Signaling Pathway - drug effects</topic><topic>Wound Healing - drug effects</topic><topic>Zebrafish - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Shouyue</creatorcontrib><creatorcontrib>Li, Jie</creatorcontrib><creatorcontrib>Song, Sicheng</creatorcontrib><creatorcontrib>Li, Jing</creatorcontrib><creatorcontrib>Tong, Rongsheng</creatorcontrib><creatorcontrib>Zang, Zhihe</creatorcontrib><creatorcontrib>Jiang, Qinglin</creatorcontrib><creatorcontrib>Cai, Lulu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular bioSystems</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Shouyue</au><au>Li, Jie</au><au>Song, Sicheng</au><au>Li, Jing</au><au>Tong, Rongsheng</au><au>Zang, Zhihe</au><au>Jiang, Qinglin</au><au>Cai, Lulu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Integrated in silico and experimental methods revealed that Arctigenin inhibited angiogenesis and HCT116 cell migration and invasion through regulating the H1F4A and Wnt/β-catenin pathway</atitle><jtitle>Molecular bioSystems</jtitle><addtitle>Mol Biosyst</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>11</volume><issue>11</issue><spage>2878</spage><epage>2884</epage><pages>2878-2884</pages><issn>1742-206X</issn><eissn>1742-2051</eissn><abstract>Arctigenin (ARG) has been previously reported to exert diverse biological activities including anti-proliferation, anti-inflammatory, and antiviral, etc. In the current study, the anti-metastasis and anti-angiogenesis activities of ARG were investigated. To further understand how ARG played these bioactivities, proteomic approaches were used to profile the proteome changes in response to ARG treatment using 2DE-MS/MS. Using these approaches, a total of 50 differentially expressed proteins were identified and clustered. Bioinformatics analysis suggested that multiple signalling pathways were involved. Moreover, ARG induced anti-metastatic and anti-angiogenesis activities were mainly accompanied by a deactivation of the Wnt/β-catenin pathway in HCT116 cells.</abstract><cop>England</cop><pmid>26267229</pmid><doi>10.1039/c5mb00439j</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Amino Acid Sequence Animals Animals, Genetically Modified Cell Movement - drug effects Cell Proliferation - drug effects Computational Biology Computer Simulation Furans - chemistry Furans - pharmacology Furans - therapeutic use HCT116 Cells Histones - metabolism Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Lignans - chemistry Lignans - pharmacology Lignans - therapeutic use Molecular Sequence Data Neoplasm Invasiveness Neovascularization, Pathologic - drug therapy Protein Interaction Maps - drug effects Proteomics Wnt Signaling Pathway - drug effects Wound Healing - drug effects Zebrafish - genetics |
| title | Integrated in silico and experimental methods revealed that Arctigenin inhibited angiogenesis and HCT116 cell migration and invasion through regulating the H1F4A and Wnt/β-catenin pathway |
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