Food restriction-induced augmentation of heroin seeking in female rats: manipulations of ovarian hormones
Rationale Food restriction augments heroin seeking in chronically food-restricted male rats under withdrawal, an effect not yet examined in female rats. Importantly, women and female rats possess an increased vulnerability to drugs of abuse, which may be mediated by fluctuations in ovarian hormones....
Gespeichert in:
| Veröffentlicht in: | Psychopharmacology 2015-10, Vol.232 (20), p.3773-3782 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3782 |
|---|---|
| container_issue | 20 |
| container_start_page | 3773 |
| container_title | Psychopharmacology |
| container_volume | 232 |
| creator | Sedki, Firas Gardner Gregory, James Luminare, Adriana D’Cunha, Tracey M. Shalev, Uri |
| description | Rationale
Food restriction augments heroin seeking in chronically food-restricted male rats under withdrawal, an effect not yet examined in female rats. Importantly, women and female rats possess an increased vulnerability to drugs of abuse, which may be mediated by fluctuations in ovarian hormones.
Objectives
We investigated the role of estradiol and progesterone in augmented heroin seeking in chronically food-restricted female rats, under withdrawal.
Methods
Female rats self-administered heroin for 10–12 days and were then allowed unrestricted (sated) or restricted access to food (FDR; ∼10 % reduction in body weight) for 14 days. On day 14, rats underwent a heroin-seeking test. Exp. 1: Rats underwent ovariectomy or sham surgery and were treated with a low dose of estradiol (5.0 % in cholesterol; subcutaneous capsule). Exp. 2: Rats underwent ovariectomy and were administered with a high dose of estradiol (0.5 mg/kg; subcutaneous) for 8 days before testing. Exp. 3: Progesterone injections (2.0 mg/kg; subcutaneous) were administered 24 h and 2 h before testing.
Results
Food restriction resulted in augmented heroin seeking, compared to sated controls. While ovariectomy had no effect, estradiol replacement attenuated the food restriction effect. Injections of progesterone had no effect on heroin seeking in either the sated or FDR groups.
Conclusions
The effect of food restriction on heroin seeking in female rats under withdrawal is as robust as previously found in males. Interestingly, estradiol replacement, but not progesterone, attenuates the food restriction effect in the ovariectomized rats, possibly due to its anorexic properties. |
| doi_str_mv | 10.1007/s00213-015-4037-4 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1722183115</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A428126342</galeid><sourcerecordid>A428126342</sourcerecordid><originalsourceid>FETCH-LOGICAL-c542t-4062e8adc925efafc4af211f2e9a4287c43fc76d1789627093ae005c7202e46c3</originalsourceid><addsrcrecordid>eNqNkl1vFSEQhomxsafVH-CNIfHGm22Zgf3yrmlsNWniTXtNkB1OqbtwhN0m_nvZnvoZTYQLyPC8k3mHYewliBMQoj3NQiDISkBdKSHbSj1hG1ASKxQtPmUbIaSsJNTdITvK-U6UpTr1jB1ig6qR0G2Yv4hx4InynLydfQyVD8NiaeBm2U4UZrMGeXT8llL0gWeizz5sebk6msxIPJk5v-WTCX63jA94Xvl4b5I3gd_GNMVA-Tk7cGbM9OLxPGY3F--uz99XVx8vP5yfXVW2VjgXIw1SZwbbY03OOKuMQwCH1BuFXWuVdLZtBmi7vsFW9NKQELVtUSCpxspj9mafd5fil6UY05PPlsbRBIpL1tAiQicB6v9AQfSd6tWKvv4DvYtLCsXIAwWlr6L7SW1LY7QPLs7J2DWpPivFAzZSYaFO_kKVPdDkbemV8yX-mwD2Aptizomc3iU_mfRVg9DrJOj9JOgyCXqdBK2K5tVjwcuniYYfiu9fXwDcA7k8hS2lXxz9M-s3gL68Ew</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1710148408</pqid></control><display><type>article</type><title>Food restriction-induced augmentation of heroin seeking in female rats: manipulations of ovarian hormones</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Sedki, Firas ; Gardner Gregory, James ; Luminare, Adriana ; D’Cunha, Tracey M. ; Shalev, Uri</creator><creatorcontrib>Sedki, Firas ; Gardner Gregory, James ; Luminare, Adriana ; D’Cunha, Tracey M. ; Shalev, Uri</creatorcontrib><description>Rationale
Food restriction augments heroin seeking in chronically food-restricted male rats under withdrawal, an effect not yet examined in female rats. Importantly, women and female rats possess an increased vulnerability to drugs of abuse, which may be mediated by fluctuations in ovarian hormones.
Objectives
We investigated the role of estradiol and progesterone in augmented heroin seeking in chronically food-restricted female rats, under withdrawal.
Methods
Female rats self-administered heroin for 10–12 days and were then allowed unrestricted (sated) or restricted access to food (FDR; ∼10 % reduction in body weight) for 14 days. On day 14, rats underwent a heroin-seeking test. Exp. 1: Rats underwent ovariectomy or sham surgery and were treated with a low dose of estradiol (5.0 % in cholesterol; subcutaneous capsule). Exp. 2: Rats underwent ovariectomy and were administered with a high dose of estradiol (0.5 mg/kg; subcutaneous) for 8 days before testing. Exp. 3: Progesterone injections (2.0 mg/kg; subcutaneous) were administered 24 h and 2 h before testing.
Results
Food restriction resulted in augmented heroin seeking, compared to sated controls. While ovariectomy had no effect, estradiol replacement attenuated the food restriction effect. Injections of progesterone had no effect on heroin seeking in either the sated or FDR groups.
Conclusions
The effect of food restriction on heroin seeking in female rats under withdrawal is as robust as previously found in males. Interestingly, estradiol replacement, but not progesterone, attenuates the food restriction effect in the ovariectomized rats, possibly due to its anorexic properties.</description><identifier>ISSN: 0033-3158</identifier><identifier>EISSN: 1432-2072</identifier><identifier>DOI: 10.1007/s00213-015-4037-4</identifier><identifier>PMID: 26246318</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Access control ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Care and treatment ; Demographic aspects ; Drug abuse ; Estradiol ; Estradiol - administration & dosage ; Estradiol - blood ; Female ; Food ; Food Deprivation - physiology ; Food supply ; Heroin ; Heroin - administration & dosage ; Heroin Dependence - blood ; Heroin Dependence - psychology ; Hormones ; Neurosciences ; Original Investigation ; Ovariectomy ; Ovary - drug effects ; Ovary - metabolism ; Pharmacology/Toxicology ; Physiological aspects ; Progesterone ; Progesterone - administration & dosage ; Progesterone - blood ; Properties ; Psychiatry ; Psychopharmacology ; Rats ; Rodents ; Self Administration</subject><ispartof>Psychopharmacology, 2015-10, Vol.232 (20), p.3773-3782</ispartof><rights>Springer-Verlag Berlin Heidelberg 2015</rights><rights>COPYRIGHT 2015 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c542t-4062e8adc925efafc4af211f2e9a4287c43fc76d1789627093ae005c7202e46c3</citedby><cites>FETCH-LOGICAL-c542t-4062e8adc925efafc4af211f2e9a4287c43fc76d1789627093ae005c7202e46c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00213-015-4037-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00213-015-4037-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26246318$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sedki, Firas</creatorcontrib><creatorcontrib>Gardner Gregory, James</creatorcontrib><creatorcontrib>Luminare, Adriana</creatorcontrib><creatorcontrib>D’Cunha, Tracey M.</creatorcontrib><creatorcontrib>Shalev, Uri</creatorcontrib><title>Food restriction-induced augmentation of heroin seeking in female rats: manipulations of ovarian hormones</title><title>Psychopharmacology</title><addtitle>Psychopharmacology</addtitle><addtitle>Psychopharmacology (Berl)</addtitle><description>Rationale
Food restriction augments heroin seeking in chronically food-restricted male rats under withdrawal, an effect not yet examined in female rats. Importantly, women and female rats possess an increased vulnerability to drugs of abuse, which may be mediated by fluctuations in ovarian hormones.
Objectives
We investigated the role of estradiol and progesterone in augmented heroin seeking in chronically food-restricted female rats, under withdrawal.
Methods
Female rats self-administered heroin for 10–12 days and were then allowed unrestricted (sated) or restricted access to food (FDR; ∼10 % reduction in body weight) for 14 days. On day 14, rats underwent a heroin-seeking test. Exp. 1: Rats underwent ovariectomy or sham surgery and were treated with a low dose of estradiol (5.0 % in cholesterol; subcutaneous capsule). Exp. 2: Rats underwent ovariectomy and were administered with a high dose of estradiol (0.5 mg/kg; subcutaneous) for 8 days before testing. Exp. 3: Progesterone injections (2.0 mg/kg; subcutaneous) were administered 24 h and 2 h before testing.
Results
Food restriction resulted in augmented heroin seeking, compared to sated controls. While ovariectomy had no effect, estradiol replacement attenuated the food restriction effect. Injections of progesterone had no effect on heroin seeking in either the sated or FDR groups.
Conclusions
The effect of food restriction on heroin seeking in female rats under withdrawal is as robust as previously found in males. Interestingly, estradiol replacement, but not progesterone, attenuates the food restriction effect in the ovariectomized rats, possibly due to its anorexic properties.</description><subject>Access control</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Care and treatment</subject><subject>Demographic aspects</subject><subject>Drug abuse</subject><subject>Estradiol</subject><subject>Estradiol - administration & dosage</subject><subject>Estradiol - blood</subject><subject>Female</subject><subject>Food</subject><subject>Food Deprivation - physiology</subject><subject>Food supply</subject><subject>Heroin</subject><subject>Heroin - administration & dosage</subject><subject>Heroin Dependence - blood</subject><subject>Heroin Dependence - psychology</subject><subject>Hormones</subject><subject>Neurosciences</subject><subject>Original Investigation</subject><subject>Ovariectomy</subject><subject>Ovary - drug effects</subject><subject>Ovary - metabolism</subject><subject>Pharmacology/Toxicology</subject><subject>Physiological aspects</subject><subject>Progesterone</subject><subject>Progesterone - administration & dosage</subject><subject>Progesterone - blood</subject><subject>Properties</subject><subject>Psychiatry</subject><subject>Psychopharmacology</subject><subject>Rats</subject><subject>Rodents</subject><subject>Self Administration</subject><issn>0033-3158</issn><issn>1432-2072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkl1vFSEQhomxsafVH-CNIfHGm22Zgf3yrmlsNWniTXtNkB1OqbtwhN0m_nvZnvoZTYQLyPC8k3mHYewliBMQoj3NQiDISkBdKSHbSj1hG1ASKxQtPmUbIaSsJNTdITvK-U6UpTr1jB1ig6qR0G2Yv4hx4InynLydfQyVD8NiaeBm2U4UZrMGeXT8llL0gWeizz5sebk6msxIPJk5v-WTCX63jA94Xvl4b5I3gd_GNMVA-Tk7cGbM9OLxPGY3F--uz99XVx8vP5yfXVW2VjgXIw1SZwbbY03OOKuMQwCH1BuFXWuVdLZtBmi7vsFW9NKQELVtUSCpxspj9mafd5fil6UY05PPlsbRBIpL1tAiQicB6v9AQfSd6tWKvv4DvYtLCsXIAwWlr6L7SW1LY7QPLs7J2DWpPivFAzZSYaFO_kKVPdDkbemV8yX-mwD2Aptizomc3iU_mfRVg9DrJOj9JOgyCXqdBK2K5tVjwcuniYYfiu9fXwDcA7k8hS2lXxz9M-s3gL68Ew</recordid><startdate>20151001</startdate><enddate>20151001</enddate><creator>Sedki, Firas</creator><creator>Gardner Gregory, James</creator><creator>Luminare, Adriana</creator><creator>D’Cunha, Tracey M.</creator><creator>Shalev, Uri</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QR</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20151001</creationdate><title>Food restriction-induced augmentation of heroin seeking in female rats: manipulations of ovarian hormones</title><author>Sedki, Firas ; Gardner Gregory, James ; Luminare, Adriana ; D’Cunha, Tracey M. ; Shalev, Uri</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c542t-4062e8adc925efafc4af211f2e9a4287c43fc76d1789627093ae005c7202e46c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Access control</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Care and treatment</topic><topic>Demographic aspects</topic><topic>Drug abuse</topic><topic>Estradiol</topic><topic>Estradiol - administration & dosage</topic><topic>Estradiol - blood</topic><topic>Female</topic><topic>Food</topic><topic>Food Deprivation - physiology</topic><topic>Food supply</topic><topic>Heroin</topic><topic>Heroin - administration & dosage</topic><topic>Heroin Dependence - blood</topic><topic>Heroin Dependence - psychology</topic><topic>Hormones</topic><topic>Neurosciences</topic><topic>Original Investigation</topic><topic>Ovariectomy</topic><topic>Ovary - drug effects</topic><topic>Ovary - metabolism</topic><topic>Pharmacology/Toxicology</topic><topic>Physiological aspects</topic><topic>Progesterone</topic><topic>Progesterone - administration & dosage</topic><topic>Progesterone - blood</topic><topic>Properties</topic><topic>Psychiatry</topic><topic>Psychopharmacology</topic><topic>Rats</topic><topic>Rodents</topic><topic>Self Administration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sedki, Firas</creatorcontrib><creatorcontrib>Gardner Gregory, James</creatorcontrib><creatorcontrib>Luminare, Adriana</creatorcontrib><creatorcontrib>D’Cunha, Tracey M.</creatorcontrib><creatorcontrib>Shalev, Uri</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Psychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sedki, Firas</au><au>Gardner Gregory, James</au><au>Luminare, Adriana</au><au>D’Cunha, Tracey M.</au><au>Shalev, Uri</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Food restriction-induced augmentation of heroin seeking in female rats: manipulations of ovarian hormones</atitle><jtitle>Psychopharmacology</jtitle><stitle>Psychopharmacology</stitle><addtitle>Psychopharmacology (Berl)</addtitle><date>2015-10-01</date><risdate>2015</risdate><volume>232</volume><issue>20</issue><spage>3773</spage><epage>3782</epage><pages>3773-3782</pages><issn>0033-3158</issn><eissn>1432-2072</eissn><abstract>Rationale
Food restriction augments heroin seeking in chronically food-restricted male rats under withdrawal, an effect not yet examined in female rats. Importantly, women and female rats possess an increased vulnerability to drugs of abuse, which may be mediated by fluctuations in ovarian hormones.
Objectives
We investigated the role of estradiol and progesterone in augmented heroin seeking in chronically food-restricted female rats, under withdrawal.
Methods
Female rats self-administered heroin for 10–12 days and were then allowed unrestricted (sated) or restricted access to food (FDR; ∼10 % reduction in body weight) for 14 days. On day 14, rats underwent a heroin-seeking test. Exp. 1: Rats underwent ovariectomy or sham surgery and were treated with a low dose of estradiol (5.0 % in cholesterol; subcutaneous capsule). Exp. 2: Rats underwent ovariectomy and were administered with a high dose of estradiol (0.5 mg/kg; subcutaneous) for 8 days before testing. Exp. 3: Progesterone injections (2.0 mg/kg; subcutaneous) were administered 24 h and 2 h before testing.
Results
Food restriction resulted in augmented heroin seeking, compared to sated controls. While ovariectomy had no effect, estradiol replacement attenuated the food restriction effect. Injections of progesterone had no effect on heroin seeking in either the sated or FDR groups.
Conclusions
The effect of food restriction on heroin seeking in female rats under withdrawal is as robust as previously found in males. Interestingly, estradiol replacement, but not progesterone, attenuates the food restriction effect in the ovariectomized rats, possibly due to its anorexic properties.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26246318</pmid><doi>10.1007/s00213-015-4037-4</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0033-3158 |
| ispartof | Psychopharmacology, 2015-10, Vol.232 (20), p.3773-3782 |
| issn | 0033-3158 1432-2072 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1722183115 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Access control Animals Biomedical and Life Sciences Biomedicine Care and treatment Demographic aspects Drug abuse Estradiol Estradiol - administration & dosage Estradiol - blood Female Food Food Deprivation - physiology Food supply Heroin Heroin - administration & dosage Heroin Dependence - blood Heroin Dependence - psychology Hormones Neurosciences Original Investigation Ovariectomy Ovary - drug effects Ovary - metabolism Pharmacology/Toxicology Physiological aspects Progesterone Progesterone - administration & dosage Progesterone - blood Properties Psychiatry Psychopharmacology Rats Rodents Self Administration |
| title | Food restriction-induced augmentation of heroin seeking in female rats: manipulations of ovarian hormones |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T03%3A05%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Food%20restriction-induced%20augmentation%20of%20heroin%20seeking%20in%20female%20rats:%20manipulations%20of%20ovarian%20hormones&rft.jtitle=Psychopharmacology&rft.au=Sedki,%20Firas&rft.date=2015-10-01&rft.volume=232&rft.issue=20&rft.spage=3773&rft.epage=3782&rft.pages=3773-3782&rft.issn=0033-3158&rft.eissn=1432-2072&rft_id=info:doi/10.1007/s00213-015-4037-4&rft_dat=%3Cgale_proqu%3EA428126342%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1710148408&rft_id=info:pmid/26246318&rft_galeid=A428126342&rfr_iscdi=true |