Distribution of calcification in carotid endarterectomy tissues: Comparison of micro-computed tomography imaging with histology
Background: Calcification in atherosclerotic plaques has been viewed as a marker of plaque stability, but whether calcification accumulates in specific anatomic sites in the carotid artery is unknown. We determined the burden and distribution of calcified plaque in carotid endarterectomy (CEA) tissu...
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| Veröffentlicht in: | Vascular medicine (London, England) England), 2014-10, Vol.19 (5), p.343-350 |
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| creator | Ababneh, Bashar Rejjal, Loui Pokharel, Yashashwi Nambi, Vijay Wang, Xukui Tung, Ching-Hsuan Han, Richard I Taylor, Addison A Kougias, Panagiotis Lumsden, Alan B Lawrie, Gerald Reardon, Michael Ballantyne, Christie M Morrisett, Joel D Brunner, Gerd |
| description | Background:
Calcification in atherosclerotic plaques has been viewed as a marker of plaque stability, but whether calcification accumulates in specific anatomic sites in the carotid artery is unknown. We determined the burden and distribution of calcified plaque in carotid endarterectomy (CEA) tissues.
Methods:
A total of 22 CEA tissues were imaged with high-resolution micro-computed tomography (micro-CT). Total plaque burden and total calcium score using the Agatston method were quantified. The Agatston score (AS) was also normalized for tissue size. Plaque and calcium distribution were analyzed separately for three CEA regions: common segment (CS), bulb segment (BS), and internal/external segments (IES).
Results:
The average CEA tissue length was 40.83 (interquartile range [IQR] 33.31–42.41) mm with total plaque burden of 103.45 (IQR: 78.84–156.81) mm3 and total AS of 38.58 (IQR 11.59–89.97). Total plaque volume was 21.02 (IQR: 14.47–25.42) mm3 in the CS, 37.89 (22.59–48.32) mm3 in the BS, and 54.05 (36.87–74.52) mm3 in the IES. Of the 22 tissues, 15 had no calcium in the CS compared with three in the bulb and two in the IES. Normalized calcified plaque was most prevalent in the BS, the IES and was least prevalent in the CS. The overall correlation of calcification between histology sections and matched micro-CT images was 0.86 (p |
| doi_str_mv | 10.1177/1358863X14549270 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1722181738</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_1358863X14549270</sage_id><sourcerecordid>1722181738</sourcerecordid><originalsourceid>FETCH-LOGICAL-c398t-6d1a12c98047ea6e4637ce7afdee673ec8b90c2d7f5f0ec5c0ba41c699b1b6f33</originalsourceid><addsrcrecordid>eNqFkU1v1DAQhi0Eou22d07IEpdeAp7YsePeqi2FSpW4gMQtcpxJ1lUSL7ajak_89bqkIFQJcbL1zjPvfBHyBth7AKU-AK_qWvLvICqhS8VekGMQShWMK_Uy_3O4eIwfkZMY7xhjSmp4TY7KCjQXtT4mP69cTMG1S3J-pr6n1ozW9c6aX4KbsxB8ch3FuTMhYUCb_HSgycW4YLygWz_tTXBxTZ-cDb6wWVsSdjSjfghmvztQN5nBzQO9d2lHd7mqH_1wOCWvejNGPHt6N-Tb9cev28_F7ZdPN9vL28JyXadCdmCgtLpmQqGRKCRXFpXpO0SpONq61cyWneqrnqGtLGuNACu1bqGVPecbcr767oP_kftOzeSixXE0M_olNqDKEmpQvP4_KoGpSouSZfTdM_TOL2HOg6yUkiJ3uiFspfJqYgzYN_uQtxEODbDm8Y7N8zvmlLdPxks7Yfcn4ffhMlCsQDQD_lX1X4YPENGoVw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1610776446</pqid></control><display><type>article</type><title>Distribution of calcification in carotid endarterectomy tissues: Comparison of micro-computed tomography imaging with histology</title><source>SAGE Complete A-Z List</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Ababneh, Bashar ; Rejjal, Loui ; Pokharel, Yashashwi ; Nambi, Vijay ; Wang, Xukui ; Tung, Ching-Hsuan ; Han, Richard I ; Taylor, Addison A ; Kougias, Panagiotis ; Lumsden, Alan B ; Lawrie, Gerald ; Reardon, Michael ; Ballantyne, Christie M ; Morrisett, Joel D ; Brunner, Gerd</creator><creatorcontrib>Ababneh, Bashar ; Rejjal, Loui ; Pokharel, Yashashwi ; Nambi, Vijay ; Wang, Xukui ; Tung, Ching-Hsuan ; Han, Richard I ; Taylor, Addison A ; Kougias, Panagiotis ; Lumsden, Alan B ; Lawrie, Gerald ; Reardon, Michael ; Ballantyne, Christie M ; Morrisett, Joel D ; Brunner, Gerd</creatorcontrib><description>Background:
Calcification in atherosclerotic plaques has been viewed as a marker of plaque stability, but whether calcification accumulates in specific anatomic sites in the carotid artery is unknown. We determined the burden and distribution of calcified plaque in carotid endarterectomy (CEA) tissues.
Methods:
A total of 22 CEA tissues were imaged with high-resolution micro-computed tomography (micro-CT). Total plaque burden and total calcium score using the Agatston method were quantified. The Agatston score (AS) was also normalized for tissue size. Plaque and calcium distribution were analyzed separately for three CEA regions: common segment (CS), bulb segment (BS), and internal/external segments (IES).
Results:
The average CEA tissue length was 40.83 (interquartile range [IQR] 33.31–42.41) mm with total plaque burden of 103.45 (IQR: 78.84–156.81) mm3 and total AS of 38.58 (IQR 11.59–89.97). Total plaque volume was 21.02 (IQR: 14.47–25.42) mm3 in the CS, 37.89 (22.59–48.32) mm3 in the BS, and 54.05 (36.87–74.52) mm3 in the IES. Of the 22 tissues, 15 had no calcium in the CS compared with three in the bulb and two in the IES. Normalized calcified plaque was most prevalent in the BS, the IES and was least prevalent in the CS. The overall correlation of calcification between histology sections and matched micro-CT images was 0.86 (p<0.001).
Conclusions:
Calcified plaque is heterogeneously distributed in CEA tissues with most in the bulb and IES regions. The amount of calcification in micro-CT slices shows a high correlation with matched histology sections.</description><identifier>ISSN: 1358-863X</identifier><identifier>EISSN: 1477-0377</identifier><identifier>DOI: 10.1177/1358863X14549270</identifier><identifier>PMID: 25193489</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Biopsy, Needle ; Calcinosis - diagnostic imaging ; Calcinosis - pathology ; Carotid Stenosis - diagnostic imaging ; Carotid Stenosis - pathology ; Carotid Stenosis - surgery ; Cohort Studies ; Endarterectomy, Carotid - methods ; Female ; Humans ; Image Processing, Computer-Assisted ; Immunohistochemistry ; Male ; Observer Variation ; Plaque, Atherosclerotic - diagnostic imaging ; Plaque, Atherosclerotic - pathology ; Sensitivity and Specificity ; Severity of Illness Index ; Tissue Culture Techniques ; X-Ray Microtomography - methods</subject><ispartof>Vascular medicine (London, England), 2014-10, Vol.19 (5), p.343-350</ispartof><rights>The Author(s) 2014</rights><rights>The Author(s) 2014.</rights><rights>SAGE Publications © Oct 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-6d1a12c98047ea6e4637ce7afdee673ec8b90c2d7f5f0ec5c0ba41c699b1b6f33</citedby><cites>FETCH-LOGICAL-c398t-6d1a12c98047ea6e4637ce7afdee673ec8b90c2d7f5f0ec5c0ba41c699b1b6f33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1358863X14549270$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1358863X14549270$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25193489$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ababneh, Bashar</creatorcontrib><creatorcontrib>Rejjal, Loui</creatorcontrib><creatorcontrib>Pokharel, Yashashwi</creatorcontrib><creatorcontrib>Nambi, Vijay</creatorcontrib><creatorcontrib>Wang, Xukui</creatorcontrib><creatorcontrib>Tung, Ching-Hsuan</creatorcontrib><creatorcontrib>Han, Richard I</creatorcontrib><creatorcontrib>Taylor, Addison A</creatorcontrib><creatorcontrib>Kougias, Panagiotis</creatorcontrib><creatorcontrib>Lumsden, Alan B</creatorcontrib><creatorcontrib>Lawrie, Gerald</creatorcontrib><creatorcontrib>Reardon, Michael</creatorcontrib><creatorcontrib>Ballantyne, Christie M</creatorcontrib><creatorcontrib>Morrisett, Joel D</creatorcontrib><creatorcontrib>Brunner, Gerd</creatorcontrib><title>Distribution of calcification in carotid endarterectomy tissues: Comparison of micro-computed tomography imaging with histology</title><title>Vascular medicine (London, England)</title><addtitle>Vasc Med</addtitle><description>Background:
Calcification in atherosclerotic plaques has been viewed as a marker of plaque stability, but whether calcification accumulates in specific anatomic sites in the carotid artery is unknown. We determined the burden and distribution of calcified plaque in carotid endarterectomy (CEA) tissues.
Methods:
A total of 22 CEA tissues were imaged with high-resolution micro-computed tomography (micro-CT). Total plaque burden and total calcium score using the Agatston method were quantified. The Agatston score (AS) was also normalized for tissue size. Plaque and calcium distribution were analyzed separately for three CEA regions: common segment (CS), bulb segment (BS), and internal/external segments (IES).
Results:
The average CEA tissue length was 40.83 (interquartile range [IQR] 33.31–42.41) mm with total plaque burden of 103.45 (IQR: 78.84–156.81) mm3 and total AS of 38.58 (IQR 11.59–89.97). Total plaque volume was 21.02 (IQR: 14.47–25.42) mm3 in the CS, 37.89 (22.59–48.32) mm3 in the BS, and 54.05 (36.87–74.52) mm3 in the IES. Of the 22 tissues, 15 had no calcium in the CS compared with three in the bulb and two in the IES. Normalized calcified plaque was most prevalent in the BS, the IES and was least prevalent in the CS. The overall correlation of calcification between histology sections and matched micro-CT images was 0.86 (p<0.001).
Conclusions:
Calcified plaque is heterogeneously distributed in CEA tissues with most in the bulb and IES regions. The amount of calcification in micro-CT slices shows a high correlation with matched histology sections.</description><subject>Biopsy, Needle</subject><subject>Calcinosis - diagnostic imaging</subject><subject>Calcinosis - pathology</subject><subject>Carotid Stenosis - diagnostic imaging</subject><subject>Carotid Stenosis - pathology</subject><subject>Carotid Stenosis - surgery</subject><subject>Cohort Studies</subject><subject>Endarterectomy, Carotid - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Observer Variation</subject><subject>Plaque, Atherosclerotic - diagnostic imaging</subject><subject>Plaque, Atherosclerotic - pathology</subject><subject>Sensitivity and Specificity</subject><subject>Severity of Illness Index</subject><subject>Tissue Culture Techniques</subject><subject>X-Ray Microtomography - methods</subject><issn>1358-863X</issn><issn>1477-0377</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkU1v1DAQhi0Eou22d07IEpdeAp7YsePeqi2FSpW4gMQtcpxJ1lUSL7ajak_89bqkIFQJcbL1zjPvfBHyBth7AKU-AK_qWvLvICqhS8VekGMQShWMK_Uy_3O4eIwfkZMY7xhjSmp4TY7KCjQXtT4mP69cTMG1S3J-pr6n1ozW9c6aX4KbsxB8ch3FuTMhYUCb_HSgycW4YLygWz_tTXBxTZ-cDb6wWVsSdjSjfghmvztQN5nBzQO9d2lHd7mqH_1wOCWvejNGPHt6N-Tb9cev28_F7ZdPN9vL28JyXadCdmCgtLpmQqGRKCRXFpXpO0SpONq61cyWneqrnqGtLGuNACu1bqGVPecbcr767oP_kftOzeSixXE0M_olNqDKEmpQvP4_KoGpSouSZfTdM_TOL2HOg6yUkiJ3uiFspfJqYgzYN_uQtxEODbDm8Y7N8zvmlLdPxks7Yfcn4ffhMlCsQDQD_lX1X4YPENGoVw</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Ababneh, Bashar</creator><creator>Rejjal, Loui</creator><creator>Pokharel, Yashashwi</creator><creator>Nambi, Vijay</creator><creator>Wang, Xukui</creator><creator>Tung, Ching-Hsuan</creator><creator>Han, Richard I</creator><creator>Taylor, Addison A</creator><creator>Kougias, Panagiotis</creator><creator>Lumsden, Alan B</creator><creator>Lawrie, Gerald</creator><creator>Reardon, Michael</creator><creator>Ballantyne, Christie M</creator><creator>Morrisett, Joel D</creator><creator>Brunner, Gerd</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7Z</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7QP</scope></search><sort><creationdate>20141001</creationdate><title>Distribution of calcification in carotid endarterectomy tissues: Comparison of micro-computed tomography imaging with histology</title><author>Ababneh, Bashar ; Rejjal, Loui ; Pokharel, Yashashwi ; Nambi, Vijay ; Wang, Xukui ; Tung, Ching-Hsuan ; Han, Richard I ; Taylor, Addison A ; Kougias, Panagiotis ; Lumsden, Alan B ; Lawrie, Gerald ; Reardon, Michael ; Ballantyne, Christie M ; Morrisett, Joel D ; Brunner, Gerd</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-6d1a12c98047ea6e4637ce7afdee673ec8b90c2d7f5f0ec5c0ba41c699b1b6f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Biopsy, Needle</topic><topic>Calcinosis - diagnostic imaging</topic><topic>Calcinosis - pathology</topic><topic>Carotid Stenosis - diagnostic imaging</topic><topic>Carotid Stenosis - pathology</topic><topic>Carotid Stenosis - surgery</topic><topic>Cohort Studies</topic><topic>Endarterectomy, Carotid - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Observer Variation</topic><topic>Plaque, Atherosclerotic - diagnostic imaging</topic><topic>Plaque, Atherosclerotic - pathology</topic><topic>Sensitivity and Specificity</topic><topic>Severity of Illness Index</topic><topic>Tissue Culture Techniques</topic><topic>X-Ray Microtomography - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ababneh, Bashar</creatorcontrib><creatorcontrib>Rejjal, Loui</creatorcontrib><creatorcontrib>Pokharel, Yashashwi</creatorcontrib><creatorcontrib>Nambi, Vijay</creatorcontrib><creatorcontrib>Wang, Xukui</creatorcontrib><creatorcontrib>Tung, Ching-Hsuan</creatorcontrib><creatorcontrib>Han, Richard I</creatorcontrib><creatorcontrib>Taylor, Addison A</creatorcontrib><creatorcontrib>Kougias, Panagiotis</creatorcontrib><creatorcontrib>Lumsden, Alan B</creatorcontrib><creatorcontrib>Lawrie, Gerald</creatorcontrib><creatorcontrib>Reardon, Michael</creatorcontrib><creatorcontrib>Ballantyne, Christie M</creatorcontrib><creatorcontrib>Morrisett, Joel D</creatorcontrib><creatorcontrib>Brunner, Gerd</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>Vascular medicine (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ababneh, Bashar</au><au>Rejjal, Loui</au><au>Pokharel, Yashashwi</au><au>Nambi, Vijay</au><au>Wang, Xukui</au><au>Tung, Ching-Hsuan</au><au>Han, Richard I</au><au>Taylor, Addison A</au><au>Kougias, Panagiotis</au><au>Lumsden, Alan B</au><au>Lawrie, Gerald</au><au>Reardon, Michael</au><au>Ballantyne, Christie M</au><au>Morrisett, Joel D</au><au>Brunner, Gerd</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution of calcification in carotid endarterectomy tissues: Comparison of micro-computed tomography imaging with histology</atitle><jtitle>Vascular medicine (London, England)</jtitle><addtitle>Vasc Med</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>19</volume><issue>5</issue><spage>343</spage><epage>350</epage><pages>343-350</pages><issn>1358-863X</issn><eissn>1477-0377</eissn><abstract>Background:
Calcification in atherosclerotic plaques has been viewed as a marker of plaque stability, but whether calcification accumulates in specific anatomic sites in the carotid artery is unknown. We determined the burden and distribution of calcified plaque in carotid endarterectomy (CEA) tissues.
Methods:
A total of 22 CEA tissues were imaged with high-resolution micro-computed tomography (micro-CT). Total plaque burden and total calcium score using the Agatston method were quantified. The Agatston score (AS) was also normalized for tissue size. Plaque and calcium distribution were analyzed separately for three CEA regions: common segment (CS), bulb segment (BS), and internal/external segments (IES).
Results:
The average CEA tissue length was 40.83 (interquartile range [IQR] 33.31–42.41) mm with total plaque burden of 103.45 (IQR: 78.84–156.81) mm3 and total AS of 38.58 (IQR 11.59–89.97). Total plaque volume was 21.02 (IQR: 14.47–25.42) mm3 in the CS, 37.89 (22.59–48.32) mm3 in the BS, and 54.05 (36.87–74.52) mm3 in the IES. Of the 22 tissues, 15 had no calcium in the CS compared with three in the bulb and two in the IES. Normalized calcified plaque was most prevalent in the BS, the IES and was least prevalent in the CS. The overall correlation of calcification between histology sections and matched micro-CT images was 0.86 (p<0.001).
Conclusions:
Calcified plaque is heterogeneously distributed in CEA tissues with most in the bulb and IES regions. The amount of calcification in micro-CT slices shows a high correlation with matched histology sections.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>25193489</pmid><doi>10.1177/1358863X14549270</doi><tpages>8</tpages></addata></record> |
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| ispartof | Vascular medicine (London, England), 2014-10, Vol.19 (5), p.343-350 |
| issn | 1358-863X 1477-0377 |
| language | eng |
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| source | SAGE Complete A-Z List; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Biopsy, Needle Calcinosis - diagnostic imaging Calcinosis - pathology Carotid Stenosis - diagnostic imaging Carotid Stenosis - pathology Carotid Stenosis - surgery Cohort Studies Endarterectomy, Carotid - methods Female Humans Image Processing, Computer-Assisted Immunohistochemistry Male Observer Variation Plaque, Atherosclerotic - diagnostic imaging Plaque, Atherosclerotic - pathology Sensitivity and Specificity Severity of Illness Index Tissue Culture Techniques X-Ray Microtomography - methods |
| title | Distribution of calcification in carotid endarterectomy tissues: Comparison of micro-computed tomography imaging with histology |
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