Phosphatidylethanolamine, but not Phosphatidylglycerol-Cardiolipin, Isolated from Two Species of Helicobacter Binds Cholesterol over Cholesteryl Ester
This study demonstrated that the cells of Helicobacter felis and Helicobacter cinaedi spontaneously absorb cholesterol added to the medium. A recent study by our group has revealed that phosphatidylethanolamine (PtdEtn) of Helicobacter pylori contains myristic acid as the most predominant saturated...
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| Veröffentlicht in: | Lipids 2015-08, Vol.50 (8), p.799-804 |
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| creator | Amgalanbaatar, Avarzed Hosoda, Kouichi Shimomura, Hirofumi |
| description | This study demonstrated that the cells of Helicobacter felis and Helicobacter cinaedi spontaneously absorb cholesterol added to the medium. A recent study by our group has revealed that phosphatidylethanolamine (PtdEtn) of Helicobacter pylori contains myristic acid as the most predominant saturated fatty acid and that the PtdEtn of this bacterium binds cholesterol more selectively than cholesteryl ester. We, therefore, isolated the PtdEtn from the two Helicobacter species to analyze the hydrophobic interaction between cholesterol and its glycerophospholipid. PtdEtn of the Helicobacter bacteria interacted more selectively with cholesterol than with cholesteryl ester, and the degree of the selective binding of cholesterol was higher in the PtdEtn than in the phosphatidylglycerol-cardiolipin of the same bacteria. These results suggest the possibility that the cells of H. felis and H. cinaedi may contain abundant PtdEtn with myristic acid. On this basis, we analyzed the PtdEtn molecular species of the Helicobacter bacteria and demonstrated that the PtdEtn containing myristic acid accounts for more than 35 % in the total PtdEtn. These results suggest that the myristoyl PtdEtn takes part in the absorption of cholesterol in H. felis and H. cinaedi. |
| doi_str_mv | 10.1007/s11745-015-4043-7 |
| format | Article |
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A recent study by our group has revealed that phosphatidylethanolamine (PtdEtn) of Helicobacter pylori contains myristic acid as the most predominant saturated fatty acid and that the PtdEtn of this bacterium binds cholesterol more selectively than cholesteryl ester. We, therefore, isolated the PtdEtn from the two Helicobacter species to analyze the hydrophobic interaction between cholesterol and its glycerophospholipid. PtdEtn of the Helicobacter bacteria interacted more selectively with cholesterol than with cholesteryl ester, and the degree of the selective binding of cholesterol was higher in the PtdEtn than in the phosphatidylglycerol-cardiolipin of the same bacteria. These results suggest the possibility that the cells of H. felis and H. cinaedi may contain abundant PtdEtn with myristic acid. On this basis, we analyzed the PtdEtn molecular species of the Helicobacter bacteria and demonstrated that the PtdEtn containing myristic acid accounts for more than 35 % in the total PtdEtn. These results suggest that the myristoyl PtdEtn takes part in the absorption of cholesterol in H. felis and H. cinaedi.</description><identifier>ISSN: 0024-4201</identifier><identifier>EISSN: 1558-9307</identifier><identifier>DOI: 10.1007/s11745-015-4043-7</identifier><identifier>PMID: 26123694</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>absorption ; bacteria ; Binding Sites ; Biomedical and Life Sciences ; Cardiolipin ; Cardiolipins - chemistry ; Cardiolipins - metabolism ; Cholesterol ; Cholesterol - metabolism ; Cholesterol Esters - metabolism ; Felis ; Helicobacter - chemistry ; Helicobacter - metabolism ; Helicobacter cinaedi ; Helicobacter felis ; Helicobacter felis - chemistry ; Helicobacter felis - metabolism ; Helicobacter pylori ; hydrophobic bonding ; Life Sciences ; Lipidology ; Medical Biochemistry ; Medicinal Chemistry ; Microbial Genetics and Genomics ; myristic acid ; Neurochemistry ; Nutrition ; Original Article ; Phosphatidylethanolamine ; phosphatidylethanolamines ; Phosphatidylethanolamines - chemistry ; Phosphatidylethanolamines - metabolism ; Phosphatidylglycerol ; Phosphatidylglycerols - chemistry ; Phosphatidylglycerols - metabolism</subject><ispartof>Lipids, 2015-08, Vol.50 (8), p.799-804</ispartof><rights>AOCS 2015</rights><rights>2015 American Oil Chemists' Society (AOCS)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5479-fdff4400cee1d05061eae275fb6e1927b13438acf6a678224e9c9ab21c5548323</citedby><cites>FETCH-LOGICAL-c5479-fdff4400cee1d05061eae275fb6e1927b13438acf6a678224e9c9ab21c5548323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11745-015-4043-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11745-015-4043-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,41486,42555,45572,45573,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26123694$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amgalanbaatar, Avarzed</creatorcontrib><creatorcontrib>Hosoda, Kouichi</creatorcontrib><creatorcontrib>Shimomura, Hirofumi</creatorcontrib><title>Phosphatidylethanolamine, but not Phosphatidylglycerol-Cardiolipin, Isolated from Two Species of Helicobacter Binds Cholesterol over Cholesteryl Ester</title><title>Lipids</title><addtitle>Lipids</addtitle><addtitle>Lipids</addtitle><description>This study demonstrated that the cells of Helicobacter felis and Helicobacter cinaedi spontaneously absorb cholesterol added to the medium. A recent study by our group has revealed that phosphatidylethanolamine (PtdEtn) of Helicobacter pylori contains myristic acid as the most predominant saturated fatty acid and that the PtdEtn of this bacterium binds cholesterol more selectively than cholesteryl ester. We, therefore, isolated the PtdEtn from the two Helicobacter species to analyze the hydrophobic interaction between cholesterol and its glycerophospholipid. PtdEtn of the Helicobacter bacteria interacted more selectively with cholesterol than with cholesteryl ester, and the degree of the selective binding of cholesterol was higher in the PtdEtn than in the phosphatidylglycerol-cardiolipin of the same bacteria. These results suggest the possibility that the cells of H. felis and H. cinaedi may contain abundant PtdEtn with myristic acid. On this basis, we analyzed the PtdEtn molecular species of the Helicobacter bacteria and demonstrated that the PtdEtn containing myristic acid accounts for more than 35 % in the total PtdEtn. These results suggest that the myristoyl PtdEtn takes part in the absorption of cholesterol in H. felis and H. cinaedi.</description><subject>absorption</subject><subject>bacteria</subject><subject>Binding Sites</subject><subject>Biomedical and Life Sciences</subject><subject>Cardiolipin</subject><subject>Cardiolipins - chemistry</subject><subject>Cardiolipins - metabolism</subject><subject>Cholesterol</subject><subject>Cholesterol - metabolism</subject><subject>Cholesterol Esters - metabolism</subject><subject>Felis</subject><subject>Helicobacter - chemistry</subject><subject>Helicobacter - metabolism</subject><subject>Helicobacter cinaedi</subject><subject>Helicobacter felis</subject><subject>Helicobacter felis - chemistry</subject><subject>Helicobacter felis - metabolism</subject><subject>Helicobacter pylori</subject><subject>hydrophobic bonding</subject><subject>Life Sciences</subject><subject>Lipidology</subject><subject>Medical Biochemistry</subject><subject>Medicinal Chemistry</subject><subject>Microbial Genetics and Genomics</subject><subject>myristic acid</subject><subject>Neurochemistry</subject><subject>Nutrition</subject><subject>Original Article</subject><subject>Phosphatidylethanolamine</subject><subject>phosphatidylethanolamines</subject><subject>Phosphatidylethanolamines - chemistry</subject><subject>Phosphatidylethanolamines - metabolism</subject><subject>Phosphatidylglycerol</subject><subject>Phosphatidylglycerols - chemistry</subject><subject>Phosphatidylglycerols - metabolism</subject><issn>0024-4201</issn><issn>1558-9307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNksFu1DAQhiMEokvhAbiAJS4cGphxnDg-lqXQSitRqe3ZcpzJritvvNhZqn0RnpdEKVXFATiNPPr-3zP6J8teI3xAAPkxIUpR5oBlLkAUuXySLbAs61wVIJ9mCwAucsEBj7IXKd2OTxSqfJ4d8Qp5USmxyH5ebkLabczg2oOnYWP64M3W9XTCmv3A-jCwx8TaHyzF4POlia0L3u1cf8Iu0igaqGVdDFt2fRfY1Y6so8RCx87JOxsaYweK7JPr28SWm-ApDZMRCz_G9kPj4NnZVF9mzzrjE726r8fZzZez6-V5vvr29WJ5usptKaTKu7brhACwRNhCCRWSIS7LrqkIFZcNFqKoje0qU8mac0HKKtNwtGUp6oIXx9n72XcXw_f9OILeumTJe9NT2CeNknOsEQv1HyhgrZALOaLv_kBvwz724yITBYpXpZr-xpmyMaQUqdO76LYmHjSCnvLVc756zFdP-erJ-c29877ZUvug-B3oCMgZuHOeDv921KuLy88g1bQfn5VpFPVrio-G_ss8b2dRZ4I26-iSvrkaD64CAIRaQvELyDjLiQ</recordid><startdate>201508</startdate><enddate>201508</enddate><creator>Amgalanbaatar, Avarzed</creator><creator>Hosoda, Kouichi</creator><creator>Shimomura, Hirofumi</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>201508</creationdate><title>Phosphatidylethanolamine, but not Phosphatidylglycerol-Cardiolipin, Isolated from Two Species of Helicobacter Binds Cholesterol over Cholesteryl Ester</title><author>Amgalanbaatar, Avarzed ; Hosoda, Kouichi ; Shimomura, Hirofumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5479-fdff4400cee1d05061eae275fb6e1927b13438acf6a678224e9c9ab21c5548323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>absorption</topic><topic>bacteria</topic><topic>Binding Sites</topic><topic>Biomedical and Life Sciences</topic><topic>Cardiolipin</topic><topic>Cardiolipins - chemistry</topic><topic>Cardiolipins - metabolism</topic><topic>Cholesterol</topic><topic>Cholesterol - metabolism</topic><topic>Cholesterol Esters - metabolism</topic><topic>Felis</topic><topic>Helicobacter - chemistry</topic><topic>Helicobacter - metabolism</topic><topic>Helicobacter cinaedi</topic><topic>Helicobacter felis</topic><topic>Helicobacter felis - chemistry</topic><topic>Helicobacter felis - metabolism</topic><topic>Helicobacter pylori</topic><topic>hydrophobic bonding</topic><topic>Life Sciences</topic><topic>Lipidology</topic><topic>Medical Biochemistry</topic><topic>Medicinal Chemistry</topic><topic>Microbial Genetics and Genomics</topic><topic>myristic acid</topic><topic>Neurochemistry</topic><topic>Nutrition</topic><topic>Original Article</topic><topic>Phosphatidylethanolamine</topic><topic>phosphatidylethanolamines</topic><topic>Phosphatidylethanolamines - chemistry</topic><topic>Phosphatidylethanolamines - metabolism</topic><topic>Phosphatidylglycerol</topic><topic>Phosphatidylglycerols - chemistry</topic><topic>Phosphatidylglycerols - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amgalanbaatar, Avarzed</creatorcontrib><creatorcontrib>Hosoda, Kouichi</creatorcontrib><creatorcontrib>Shimomura, Hirofumi</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Lipids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amgalanbaatar, Avarzed</au><au>Hosoda, Kouichi</au><au>Shimomura, Hirofumi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phosphatidylethanolamine, but not Phosphatidylglycerol-Cardiolipin, Isolated from Two Species of Helicobacter Binds Cholesterol over Cholesteryl Ester</atitle><jtitle>Lipids</jtitle><stitle>Lipids</stitle><addtitle>Lipids</addtitle><date>2015-08</date><risdate>2015</risdate><volume>50</volume><issue>8</issue><spage>799</spage><epage>804</epage><pages>799-804</pages><issn>0024-4201</issn><eissn>1558-9307</eissn><abstract>This study demonstrated that the cells of Helicobacter felis and Helicobacter cinaedi spontaneously absorb cholesterol added to the medium. A recent study by our group has revealed that phosphatidylethanolamine (PtdEtn) of Helicobacter pylori contains myristic acid as the most predominant saturated fatty acid and that the PtdEtn of this bacterium binds cholesterol more selectively than cholesteryl ester. We, therefore, isolated the PtdEtn from the two Helicobacter species to analyze the hydrophobic interaction between cholesterol and its glycerophospholipid. PtdEtn of the Helicobacter bacteria interacted more selectively with cholesterol than with cholesteryl ester, and the degree of the selective binding of cholesterol was higher in the PtdEtn than in the phosphatidylglycerol-cardiolipin of the same bacteria. These results suggest the possibility that the cells of H. felis and H. cinaedi may contain abundant PtdEtn with myristic acid. On this basis, we analyzed the PtdEtn molecular species of the Helicobacter bacteria and demonstrated that the PtdEtn containing myristic acid accounts for more than 35 % in the total PtdEtn. These results suggest that the myristoyl PtdEtn takes part in the absorption of cholesterol in H. felis and H. cinaedi.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26123694</pmid><doi>10.1007/s11745-015-4043-7</doi><tpages>6</tpages></addata></record> |
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| subjects | absorption bacteria Binding Sites Biomedical and Life Sciences Cardiolipin Cardiolipins - chemistry Cardiolipins - metabolism Cholesterol Cholesterol - metabolism Cholesterol Esters - metabolism Felis Helicobacter - chemistry Helicobacter - metabolism Helicobacter cinaedi Helicobacter felis Helicobacter felis - chemistry Helicobacter felis - metabolism Helicobacter pylori hydrophobic bonding Life Sciences Lipidology Medical Biochemistry Medicinal Chemistry Microbial Genetics and Genomics myristic acid Neurochemistry Nutrition Original Article Phosphatidylethanolamine phosphatidylethanolamines Phosphatidylethanolamines - chemistry Phosphatidylethanolamines - metabolism Phosphatidylglycerol Phosphatidylglycerols - chemistry Phosphatidylglycerols - metabolism |
| title | Phosphatidylethanolamine, but not Phosphatidylglycerol-Cardiolipin, Isolated from Two Species of Helicobacter Binds Cholesterol over Cholesteryl Ester |
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