Integrated PET/MRI for whole-body staging of patients with primary cervical cancer: preliminary results
Purpose To assess the diagnostic value of integrated PET/MRI for whole-body staging of cervical cancer patients, as well as to investigate a potential association between PET/MRI derived functional parameters and prognostic factors of cervical cancer. Methods The present study was approved by the lo...
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| Veröffentlicht in: | European journal of nuclear medicine and molecular imaging 2015-11, Vol.42 (12), p.1814-1824 |
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| container_title | European journal of nuclear medicine and molecular imaging |
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| creator | Grueneisen, Johannes Schaarschmidt, Benedikt Michael Heubner, Martin Aktas, Bahriye Kinner, Sonja Forsting, Michael Lauenstein, Thomas Ruhlmann, Verena Umutlu, Lale |
| description | Purpose
To assess the diagnostic value of integrated PET/MRI for whole-body staging of cervical cancer patients, as well as to investigate a potential association between PET/MRI derived functional parameters and prognostic factors of cervical cancer.
Methods
The present study was approved by the local institutional review board. Twenty-seven patients with histopathologically confirmed cervical cancer were prospectively enrolled in our study. All patients underwent a whole-body PET/MRI examination after written informed consent was obtained. Two radiologists separately evaluated the PET/MRI data sets regarding the determination of local tumor extent of primary cervical cancer lesions, as well as detection of nodal and distant metastases. Furthermore, SUV and ADC values of primary tumor lesions were analyzed and correlated with dedicated prognostic factors of cervical cancer. Results based on histopathology and cross-sectional imaging follow-up served as the reference standard.
Results
PET/MRI enabled the detection of all 27 primary tumor lesions of the uterine cervix and allowed for the correct determination of the T-stage in 23 (85 %) out of the 27 patients. Furthermore, the calculated sensitivity, specificity and diagnostic accuracy for the detection of nodal positive patients (
n
= 11) were 91 %, 94 % and 93 %, respectively. PET/MRI correctly identified regional metastatic disease (N1-stage) in 8/10 (80 %) patients and non-regional lymph node metastases in 5/5 (100 %) patients. In addition, quantitative analysis of PET and MRI derived functional parameters (SUV; ADC values) revealed a significant correlation with pathological grade and tumor size (
p
|
| doi_str_mv | 10.1007/s00259-015-3131-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1722181088</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3822846251</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-bab4ada53c2a43628bc0561e7c004f66ffc089feb67131188aab4b919bf167f13</originalsourceid><addsrcrecordid>eNqNkV9LHDEUxYNUdN36AXwpgb70Zbr3Zv4k6VsRWxdWlKLPIZNNxpHZmW2SqfjtzbBbEUHwKRfO79xw7iHkDOE7AvBFAGClzADLLMccs_KAzLBCmXEQ8tPLzOGYnITwAICCCXlEjlkSJGI-I82yj7bxOto1vbm4XVz9WVI3ePp4P3Q2q4f1Ew1RN23f0MHRrY6t7WOgj228p1vfbrR_osb6f63RHTW6T_OPJNiu3bT9JHobxi6Gz-TQ6S7Y0_07J3e_Lm7PL7PV9e_l-c9VZgooY1brutBrXeaG6SKvmKgNlBVabgAKV1XOmRTN2briKTAKoZOhlihrhxV3mM_Jt93erR_-jjZEtWmDsV2nezuMQSFnDAWCEB9AUUgoGOcJ_foGfRhG36cgE8VlJcu8TBTuKOOHELx1an8hhaCmwtSuMJUKU1NhavJ82W8e641dvzj-N5QAtgNCkvrG-ldfv7v1GTlroBU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1717969535</pqid></control><display><type>article</type><title>Integrated PET/MRI for whole-body staging of patients with primary cervical cancer: preliminary results</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Grueneisen, Johannes ; Schaarschmidt, Benedikt Michael ; Heubner, Martin ; Aktas, Bahriye ; Kinner, Sonja ; Forsting, Michael ; Lauenstein, Thomas ; Ruhlmann, Verena ; Umutlu, Lale</creator><creatorcontrib>Grueneisen, Johannes ; Schaarschmidt, Benedikt Michael ; Heubner, Martin ; Aktas, Bahriye ; Kinner, Sonja ; Forsting, Michael ; Lauenstein, Thomas ; Ruhlmann, Verena ; Umutlu, Lale</creatorcontrib><description>Purpose
To assess the diagnostic value of integrated PET/MRI for whole-body staging of cervical cancer patients, as well as to investigate a potential association between PET/MRI derived functional parameters and prognostic factors of cervical cancer.
Methods
The present study was approved by the local institutional review board. Twenty-seven patients with histopathologically confirmed cervical cancer were prospectively enrolled in our study. All patients underwent a whole-body PET/MRI examination after written informed consent was obtained. Two radiologists separately evaluated the PET/MRI data sets regarding the determination of local tumor extent of primary cervical cancer lesions, as well as detection of nodal and distant metastases. Furthermore, SUV and ADC values of primary tumor lesions were analyzed and correlated with dedicated prognostic factors of cervical cancer. Results based on histopathology and cross-sectional imaging follow-up served as the reference standard.
Results
PET/MRI enabled the detection of all 27 primary tumor lesions of the uterine cervix and allowed for the correct determination of the T-stage in 23 (85 %) out of the 27 patients. Furthermore, the calculated sensitivity, specificity and diagnostic accuracy for the detection of nodal positive patients (
n
= 11) were 91 %, 94 % and 93 %, respectively. PET/MRI correctly identified regional metastatic disease (N1-stage) in 8/10 (80 %) patients and non-regional lymph node metastases in 5/5 (100 %) patients. In addition, quantitative analysis of PET and MRI derived functional parameters (SUV; ADC values) revealed a significant correlation with pathological grade and tumor size (
p
< 0.05).
Conclusions
The present study demonstrates the high potential of integrated PET/MRI for the assessment of primary tumor and the detection of lymph node metastases in patients with cervical cancer. Providing additional prognostic information, PET/MRI may serve as a valuable diagnostic tool for cervical cancer patients in a pretreatment setting.</description><identifier>ISSN: 1619-7070</identifier><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/s00259-015-3131-5</identifier><identifier>PMID: 26199113</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Cardiology ; Cervical cancer ; Female ; Humans ; Imaging ; Magnetic Resonance Imaging ; Medical diagnosis ; Medical prognosis ; Medicine ; Medicine & Public Health ; Middle Aged ; Multimodal Imaging ; Neoplasm Metastasis ; Neoplasm Staging ; NMR ; Nuclear magnetic resonance ; Nuclear Medicine ; Oncology ; Original Article ; Orthopedics ; Positron-Emission Tomography ; Prognosis ; Radiology ; Tomography ; Uterine Cervical Neoplasms - diagnosis ; Uterine Cervical Neoplasms - diagnostic imaging ; Uterine Cervical Neoplasms - pathology ; Whole Body Imaging</subject><ispartof>European journal of nuclear medicine and molecular imaging, 2015-11, Vol.42 (12), p.1814-1824</ispartof><rights>Springer-Verlag Berlin Heidelberg 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-bab4ada53c2a43628bc0561e7c004f66ffc089feb67131188aab4b919bf167f13</citedby><cites>FETCH-LOGICAL-c405t-bab4ada53c2a43628bc0561e7c004f66ffc089feb67131188aab4b919bf167f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00259-015-3131-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00259-015-3131-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27931,27932,41495,42564,51326</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26199113$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grueneisen, Johannes</creatorcontrib><creatorcontrib>Schaarschmidt, Benedikt Michael</creatorcontrib><creatorcontrib>Heubner, Martin</creatorcontrib><creatorcontrib>Aktas, Bahriye</creatorcontrib><creatorcontrib>Kinner, Sonja</creatorcontrib><creatorcontrib>Forsting, Michael</creatorcontrib><creatorcontrib>Lauenstein, Thomas</creatorcontrib><creatorcontrib>Ruhlmann, Verena</creatorcontrib><creatorcontrib>Umutlu, Lale</creatorcontrib><title>Integrated PET/MRI for whole-body staging of patients with primary cervical cancer: preliminary results</title><title>European journal of nuclear medicine and molecular imaging</title><addtitle>Eur J Nucl Med Mol Imaging</addtitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><description>Purpose
To assess the diagnostic value of integrated PET/MRI for whole-body staging of cervical cancer patients, as well as to investigate a potential association between PET/MRI derived functional parameters and prognostic factors of cervical cancer.
Methods
The present study was approved by the local institutional review board. Twenty-seven patients with histopathologically confirmed cervical cancer were prospectively enrolled in our study. All patients underwent a whole-body PET/MRI examination after written informed consent was obtained. Two radiologists separately evaluated the PET/MRI data sets regarding the determination of local tumor extent of primary cervical cancer lesions, as well as detection of nodal and distant metastases. Furthermore, SUV and ADC values of primary tumor lesions were analyzed and correlated with dedicated prognostic factors of cervical cancer. Results based on histopathology and cross-sectional imaging follow-up served as the reference standard.
Results
PET/MRI enabled the detection of all 27 primary tumor lesions of the uterine cervix and allowed for the correct determination of the T-stage in 23 (85 %) out of the 27 patients. Furthermore, the calculated sensitivity, specificity and diagnostic accuracy for the detection of nodal positive patients (
n
= 11) were 91 %, 94 % and 93 %, respectively. PET/MRI correctly identified regional metastatic disease (N1-stage) in 8/10 (80 %) patients and non-regional lymph node metastases in 5/5 (100 %) patients. In addition, quantitative analysis of PET and MRI derived functional parameters (SUV; ADC values) revealed a significant correlation with pathological grade and tumor size (
p
< 0.05).
Conclusions
The present study demonstrates the high potential of integrated PET/MRI for the assessment of primary tumor and the detection of lymph node metastases in patients with cervical cancer. Providing additional prognostic information, PET/MRI may serve as a valuable diagnostic tool for cervical cancer patients in a pretreatment setting.</description><subject>Adult</subject><subject>Aged</subject><subject>Cardiology</subject><subject>Cervical cancer</subject><subject>Female</subject><subject>Humans</subject><subject>Imaging</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical diagnosis</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multimodal Imaging</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasm Staging</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Nuclear Medicine</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Positron-Emission Tomography</subject><subject>Prognosis</subject><subject>Radiology</subject><subject>Tomography</subject><subject>Uterine Cervical Neoplasms - diagnosis</subject><subject>Uterine Cervical Neoplasms - diagnostic imaging</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>Whole Body Imaging</subject><issn>1619-7070</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkV9LHDEUxYNUdN36AXwpgb70Zbr3Zv4k6VsRWxdWlKLPIZNNxpHZmW2SqfjtzbBbEUHwKRfO79xw7iHkDOE7AvBFAGClzADLLMccs_KAzLBCmXEQ8tPLzOGYnITwAICCCXlEjlkSJGI-I82yj7bxOto1vbm4XVz9WVI3ePp4P3Q2q4f1Ew1RN23f0MHRrY6t7WOgj228p1vfbrR_osb6f63RHTW6T_OPJNiu3bT9JHobxi6Gz-TQ6S7Y0_07J3e_Lm7PL7PV9e_l-c9VZgooY1brutBrXeaG6SKvmKgNlBVabgAKV1XOmRTN2briKTAKoZOhlihrhxV3mM_Jt93erR_-jjZEtWmDsV2nezuMQSFnDAWCEB9AUUgoGOcJ_foGfRhG36cgE8VlJcu8TBTuKOOHELx1an8hhaCmwtSuMJUKU1NhavJ82W8e641dvzj-N5QAtgNCkvrG-ldfv7v1GTlroBU</recordid><startdate>20151101</startdate><enddate>20151101</enddate><creator>Grueneisen, Johannes</creator><creator>Schaarschmidt, Benedikt Michael</creator><creator>Heubner, Martin</creator><creator>Aktas, Bahriye</creator><creator>Kinner, Sonja</creator><creator>Forsting, Michael</creator><creator>Lauenstein, Thomas</creator><creator>Ruhlmann, Verena</creator><creator>Umutlu, Lale</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20151101</creationdate><title>Integrated PET/MRI for whole-body staging of patients with primary cervical cancer: preliminary results</title><author>Grueneisen, Johannes ; Schaarschmidt, Benedikt Michael ; Heubner, Martin ; Aktas, Bahriye ; Kinner, Sonja ; Forsting, Michael ; Lauenstein, Thomas ; Ruhlmann, Verena ; Umutlu, Lale</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-bab4ada53c2a43628bc0561e7c004f66ffc089feb67131188aab4b919bf167f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Cardiology</topic><topic>Cervical cancer</topic><topic>Female</topic><topic>Humans</topic><topic>Imaging</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical diagnosis</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Multimodal Imaging</topic><topic>Neoplasm Metastasis</topic><topic>Neoplasm Staging</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Nuclear Medicine</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Positron-Emission Tomography</topic><topic>Prognosis</topic><topic>Radiology</topic><topic>Tomography</topic><topic>Uterine Cervical Neoplasms - diagnosis</topic><topic>Uterine Cervical Neoplasms - diagnostic imaging</topic><topic>Uterine Cervical Neoplasms - pathology</topic><topic>Whole Body Imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grueneisen, Johannes</creatorcontrib><creatorcontrib>Schaarschmidt, Benedikt Michael</creatorcontrib><creatorcontrib>Heubner, Martin</creatorcontrib><creatorcontrib>Aktas, Bahriye</creatorcontrib><creatorcontrib>Kinner, Sonja</creatorcontrib><creatorcontrib>Forsting, Michael</creatorcontrib><creatorcontrib>Lauenstein, Thomas</creatorcontrib><creatorcontrib>Ruhlmann, Verena</creatorcontrib><creatorcontrib>Umutlu, Lale</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>European journal of nuclear medicine and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grueneisen, Johannes</au><au>Schaarschmidt, Benedikt Michael</au><au>Heubner, Martin</au><au>Aktas, Bahriye</au><au>Kinner, Sonja</au><au>Forsting, Michael</au><au>Lauenstein, Thomas</au><au>Ruhlmann, Verena</au><au>Umutlu, Lale</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Integrated PET/MRI for whole-body staging of patients with primary cervical cancer: preliminary results</atitle><jtitle>European journal of nuclear medicine and molecular imaging</jtitle><stitle>Eur J Nucl Med Mol Imaging</stitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><date>2015-11-01</date><risdate>2015</risdate><volume>42</volume><issue>12</issue><spage>1814</spage><epage>1824</epage><pages>1814-1824</pages><issn>1619-7070</issn><eissn>1619-7089</eissn><abstract>Purpose
To assess the diagnostic value of integrated PET/MRI for whole-body staging of cervical cancer patients, as well as to investigate a potential association between PET/MRI derived functional parameters and prognostic factors of cervical cancer.
Methods
The present study was approved by the local institutional review board. Twenty-seven patients with histopathologically confirmed cervical cancer were prospectively enrolled in our study. All patients underwent a whole-body PET/MRI examination after written informed consent was obtained. Two radiologists separately evaluated the PET/MRI data sets regarding the determination of local tumor extent of primary cervical cancer lesions, as well as detection of nodal and distant metastases. Furthermore, SUV and ADC values of primary tumor lesions were analyzed and correlated with dedicated prognostic factors of cervical cancer. Results based on histopathology and cross-sectional imaging follow-up served as the reference standard.
Results
PET/MRI enabled the detection of all 27 primary tumor lesions of the uterine cervix and allowed for the correct determination of the T-stage in 23 (85 %) out of the 27 patients. Furthermore, the calculated sensitivity, specificity and diagnostic accuracy for the detection of nodal positive patients (
n
= 11) were 91 %, 94 % and 93 %, respectively. PET/MRI correctly identified regional metastatic disease (N1-stage) in 8/10 (80 %) patients and non-regional lymph node metastases in 5/5 (100 %) patients. In addition, quantitative analysis of PET and MRI derived functional parameters (SUV; ADC values) revealed a significant correlation with pathological grade and tumor size (
p
< 0.05).
Conclusions
The present study demonstrates the high potential of integrated PET/MRI for the assessment of primary tumor and the detection of lymph node metastases in patients with cervical cancer. Providing additional prognostic information, PET/MRI may serve as a valuable diagnostic tool for cervical cancer patients in a pretreatment setting.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26199113</pmid><doi>10.1007/s00259-015-3131-5</doi><tpages>11</tpages></addata></record> |
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| identifier | ISSN: 1619-7070 |
| ispartof | European journal of nuclear medicine and molecular imaging, 2015-11, Vol.42 (12), p.1814-1824 |
| issn | 1619-7070 1619-7089 |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Adult Aged Cardiology Cervical cancer Female Humans Imaging Magnetic Resonance Imaging Medical diagnosis Medical prognosis Medicine Medicine & Public Health Middle Aged Multimodal Imaging Neoplasm Metastasis Neoplasm Staging NMR Nuclear magnetic resonance Nuclear Medicine Oncology Original Article Orthopedics Positron-Emission Tomography Prognosis Radiology Tomography Uterine Cervical Neoplasms - diagnosis Uterine Cervical Neoplasms - diagnostic imaging Uterine Cervical Neoplasms - pathology Whole Body Imaging |
| title | Integrated PET/MRI for whole-body staging of patients with primary cervical cancer: preliminary results |
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