SNCA rs3822086 C>T Polymorphism Increases the Susceptibility to Parkinson's Disease in a Chinese Han Population

Protofibrils of alpha-synuclein mediate neuronal cell death and propagate Parkinson's disease (PD). In this study, we investigated the relationship between the rs3822086 C>T polymorphism located in the fourth intron of the alpha-synuclein (SNCA) gene and susceptibility to PD in a Chinese Han...

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Veröffentlicht in:	Genetic testing and molecular biomarkers 2015-09, Vol.19 (9), p.481-487
Hauptverfasser:	Jian, Chong-Dong, Huang, Jian-Min, Meng, Lan-Qing, Li, Xue-Bin, Huang, Rui-Ya, Shi, Sheng-Liang, Wu, Yuan, Qin, Chao, Chen, Jin, Zhang, Yan-Mei, Wang, Shuang, Feng, Yin-Ling, Zhou, Sheng-Nian
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged alpha-Synuclein - genetics Asian Continental Ancestry Group - genetics Case-Control Studies China Ethnic Groups - genetics Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Humans Male Middle Aged Parkinson Disease - genetics Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide Risk Factors
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