Effects of hydroxycamptothecin on the expression of matrix metalloproteinase-1 (MMP-1), tissue inhibitor of MMP-1, and type I collagen in rats with pulmonary fibrosis

The aim of this study was to investigate the effects of hydroxycamptothecin (HCPT) on the expression of matrix metalloproteinase-1 (MMP-1), tissue inhibitor of MMP-1 (TIMP-1), and type I collagen in the lung tissue of rats with pulmonary fibrosis induced by bleomycin A5. We used hematoxylin eosin st...

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Veröffentlicht in:	Genetics and molecular research 2015-05, Vol.14 (2), p.4625-4632
Hauptverfasser:	Hu, G-X, Yao, S-T, Zeng, L-H, Peng, Y-Z, Zheng, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Camptothecin - analogs & derivatives Camptothecin - pharmacology Camptothecin - therapeutic use Collagen Type I - metabolism Female Male Matrix Metalloproteinase 1 - genetics Matrix Metalloproteinase 1 - metabolism Pulmonary Fibrosis - drug therapy Rats Rats, Sprague-Dawley RNA, Messenger - genetics Tissue Inhibitor of Metalloproteinase-1 - genetics Tissue Inhibitor of Metalloproteinase-1 - metabolism
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