Immunoregulatory role of IL-35 in T cells of patients with rheumatoid arthritis

IL-35 is the most recently identified member of the IL-12 family. It consists of EBV-induced gene 3 (EBI3) and IL-12α chain p35. We investigated whether IL-35 enhances the in vitro immunosuppressive function of peripheral blood isolated from patients with RA. Peripheral blood was harvested from 17 a...

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Veröffentlicht in:	Rheumatology (Oxford, England) England), 2015-08, Vol.54 (8), p.1498-1506
Hauptverfasser:	Nakano, Souichiro, Morimoto, Shinji, Suzuki, Satoshi, Tsushima, Hiroshi, Yamanaka, Kenjiro, Sekigawa, Iwao, Takasaki, Yoshinari
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - pathology Arthritis, Rheumatoid - physiopathology Autoimmunity - physiology Case-Control Studies CD2 Antigens - metabolism CD28 Antigens - metabolism CD3 Complex - metabolism Cell Count Cytokines - metabolism Female Humans Immunosuppression Interleukin-10 - metabolism Interleukins - genetics Interleukins - physiology Male Middle Aged T-Lymphocytes, Regulatory - pathology T-Lymphocytes, Regulatory - physiology
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