Efficacy and Safety of Treatment With an Anti-M2e Monoclonal Antibody in Experimental Human Influenza

Background. The efficacy of TCN-032, a human monoclonal antibody targeting a conserved epitope on M2e, was explored in experimental human influenza. Methods. Healthy volunteers were inoculated with influenza A/Wisconsin/67/2005 (H3N2) and received a single dose of the study drug, TCN-032, or placebo...

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Veröffentlicht in:	The Journal of infectious diseases 2015-04, Vol.211 (7), p.1038-1044
Hauptverfasser:	Ramos, Eleanor L., Mitcham, Jennifer L., Koller, Teri D., Bonavia, Aurelio, Usner, Dale W., Balaratnam, Ganesh, Fredlund, Paul, Swiderek, Kristine M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antibodies, Monoclonal - therapeutic use Cytokines - blood Double-Blind Method Female Humans Immunologic Factors - therapeutic use Influenza A Virus, H3N2 Subtype - drug effects Influenza A Virus, H3N2 Subtype - immunology Influenza, Human - drug therapy Influenza, Human - immunology Influenza, Human - virology Male Middle Aged Oseltamivir - administration & dosage Retrospective Studies Treatment Outcome Viral Load Virus Shedding VIRUSES Young Adult
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