Inactivated Sendai virus induces apoptosis and autophagy via the PI3K/Akt/mTOR/p70S6K pathway in human non-small cell lung cancer cells

Inactivated Sendai virus (HVJ-E) has shown potential anticancer efficacy in various cancer cells. However, the ability of HVJ-E to regulate cancer cell survival and death remains largely unknown. In the present study we first found that HVJ-E exhibited cytotoxic effects in the non-small cell lung ca...

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Veröffentlicht in:	Biochemical and biophysical research communications 2015-09, Vol.465 (1), p.64-70
Hauptverfasser:	Zhang, Quan, Zhu, Huixia, Xu, Xiaoshuang, Li, Lingyu, Tan, Haiming, Cai, Xiaoyao
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis Apoptosis - genetics Autophagy Autophagy - genetics Cell Line, Tumor Cisplatin - pharmacology Drug Resistance, Neoplasm Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - pathology Epithelial Cells - virology Gene Expression Regulation, Neoplastic Humans Inactivated Sendai virus (HVJ-E) MAP Kinase Kinase 4 - genetics MAP Kinase Kinase 4 - metabolism p38 Mitogen-Activated Protein Kinases - genetics p38 Mitogen-Activated Protein Kinases - metabolism Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism PI3K/AKT/mTOR/p70S6K Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Respiratory Mucosa - drug effects Respiratory Mucosa - metabolism Respiratory Mucosa - pathology Respiratory Mucosa - virology Ribosomal Protein S6 Kinases, 70-kDa - genetics Ribosomal Protein S6 Kinases, 70-kDa - metabolism Sendai virus Sendai virus - chemistry Signal Transduction TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism Virus Inactivation
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