CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses

Th17 responses are critical to a variety of human autoimmune diseases, and therapeutic targeting with monoclonal antibodies against IL-17 and IL-23 has shown considerable promise. Here, we report data to support selective bromodomain blockade of the transcriptional coactivators CBP (CREB binding pro...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2015-08, Vol.112 (34), p.10768-10773
Hauptverfasser:	Hammitzsch, Ariane, Tallant, Cynthia, Fedorov, Oleg, O’Mahony, Alison, Brennan, Paul E., Hay, Duncan A., Martinez, Fernando O., Al-Mossawi, M. Hussein, de Wit, Jelle, Vecellio, Matteo, Wells, Christopher, Wordsworth, Paul, Müller, Susanne, Knapp, Stefan, Bowness, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Arthritis, Psoriatic - metabolism Arthritis, Psoriatic - pathology Autoimmune diseases Azepines - pharmacology Benzimidazoles - chemistry Benzimidazoles - pharmacology Biological Sciences Calorimetry CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - metabolism Cells, Cultured Clinical trials Crystallography, X-Ray Cytokines Drug Evaluation, Preclinical Female Gene expression Gene Expression Regulation - drug effects Humans Immunosuppressive Agents - chemistry Immunosuppressive Agents - pharmacology Interleukin-17 - biosynthesis Interleukin-17 - genetics Interleukin-17 - metabolism Isoxazoles - chemistry Isoxazoles - pharmacology Kinetics Male Medical treatment Middle Aged Models, Molecular Molecular Structure Monoclonal antibodies p300-CBP Transcription Factors - antagonists & inhibitors Protein Conformation Protein Structure, Tertiary - drug effects Recombinant Proteins - metabolism Spondylitis, Ankylosing - metabolism Spondylitis, Ankylosing - pathology Structure-Activity Relationship T cell receptors Th17 Cells - drug effects Th17 Cells - immunology Triazoles - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!