Transplantation of umbilical cord blood mononuclear cells increases levels of nerve growth factor in the cerebrospinal fluid of patients with autism
We aimed to evaluate the levels of growth factors in the cerebrospinal fluid (CSF) of patients with autism after transplantation of umbilical cord blood mononuclear cells (CBMNCs). Fourteen subjects diagnosed with autism received transplantation of CBMNCs first through intravenous infusion, and thre...
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| Veröffentlicht in: | Genetics and molecular research 2015-07, Vol.14 (3), p.8725-8732 |
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| container_title | Genetics and molecular research |
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| creator | Li, Q Chen, C-F Wang, D-Y Lü, Y-T Huan, Y Liu, M Ge, R-C Chen, X-W Qi, H-S An, L Hu, X |
| description | We aimed to evaluate the levels of growth factors in the cerebrospinal fluid (CSF) of patients with autism after transplantation of umbilical cord blood mononuclear cells (CBMNCs). Fourteen subjects diagnosed with autism received transplantation of CBMNCs first through intravenous infusion, and three times subsequently through intrathecal injections. A 2-mL sample of CSF was taken before each intrathecal injection. CSF levels of nerve growth factor (NGF), vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (bFGF) were determined by enzyme-linked immunosorbent assay. All data are reported as means ± SD and were analyzed using the SPSS 10.0 software. One-way analysis of variance with post-hoc F-and Q-tests were performed for comparisons. NGF levels in the CSF were significantly increased after transplantation (213.54 ± 56.38 after the third versus 28.32 ± 12.22 ng/L after the first transplantation; P < 0.05), while VEGF and bFGF levels did not change significantly. Therefore, transplantation of CBMNCs could increase NGF levels in the CSF of patients with autism. |
| doi_str_mv | 10.4238/2015.July.31.21 |
| format | Article |
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Fourteen subjects diagnosed with autism received transplantation of CBMNCs first through intravenous infusion, and three times subsequently through intrathecal injections. A 2-mL sample of CSF was taken before each intrathecal injection. CSF levels of nerve growth factor (NGF), vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (bFGF) were determined by enzyme-linked immunosorbent assay. All data are reported as means ± SD and were analyzed using the SPSS 10.0 software. One-way analysis of variance with post-hoc F-and Q-tests were performed for comparisons. NGF levels in the CSF were significantly increased after transplantation (213.54 ± 56.38 after the third versus 28.32 ± 12.22 ng/L after the first transplantation; P < 0.05), while VEGF and bFGF levels did not change significantly. Therefore, transplantation of CBMNCs could increase NGF levels in the CSF of patients with autism.</description><identifier>ISSN: 1676-5680</identifier><identifier>EISSN: 1676-5680</identifier><identifier>DOI: 10.4238/2015.July.31.21</identifier><identifier>PMID: 26345804</identifier><language>eng</language><publisher>Brazil</publisher><subject>Autistic Disorder - cerebrospinal fluid ; Autistic Disorder - therapy ; Child ; Child, Preschool ; Female ; Fetal Blood - cytology ; Fibroblast Growth Factor 2 - cerebrospinal fluid ; Humans ; Leukocytes, Mononuclear - transplantation ; Male ; Nerve Growth Factor - cerebrospinal fluid ; Treatment Outcome ; Vascular Endothelial Growth Factor A - cerebrospinal fluid</subject><ispartof>Genetics and molecular research, 2015-07, Vol.14 (3), p.8725-8732</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-946161c90a9d1eaf0a9a3312c1014888f19fb07a777200f0935d0cd8bf0d05fa3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26345804$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Q</creatorcontrib><creatorcontrib>Chen, C-F</creatorcontrib><creatorcontrib>Wang, D-Y</creatorcontrib><creatorcontrib>Lü, Y-T</creatorcontrib><creatorcontrib>Huan, Y</creatorcontrib><creatorcontrib>Liu, M</creatorcontrib><creatorcontrib>Ge, R-C</creatorcontrib><creatorcontrib>Chen, X-W</creatorcontrib><creatorcontrib>Qi, H-S</creatorcontrib><creatorcontrib>An, L</creatorcontrib><creatorcontrib>Hu, X</creatorcontrib><title>Transplantation of umbilical cord blood mononuclear cells increases levels of nerve growth factor in the cerebrospinal fluid of patients with autism</title><title>Genetics and molecular research</title><addtitle>Genet Mol Res</addtitle><description>We aimed to evaluate the levels of growth factors in the cerebrospinal fluid (CSF) of patients with autism after transplantation of umbilical cord blood mononuclear cells (CBMNCs). Fourteen subjects diagnosed with autism received transplantation of CBMNCs first through intravenous infusion, and three times subsequently through intrathecal injections. A 2-mL sample of CSF was taken before each intrathecal injection. CSF levels of nerve growth factor (NGF), vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (bFGF) were determined by enzyme-linked immunosorbent assay. All data are reported as means ± SD and were analyzed using the SPSS 10.0 software. One-way analysis of variance with post-hoc F-and Q-tests were performed for comparisons. NGF levels in the CSF were significantly increased after transplantation (213.54 ± 56.38 after the third versus 28.32 ± 12.22 ng/L after the first transplantation; P < 0.05), while VEGF and bFGF levels did not change significantly. Therefore, transplantation of CBMNCs could increase NGF levels in the CSF of patients with autism.</description><subject>Autistic Disorder - cerebrospinal fluid</subject><subject>Autistic Disorder - therapy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Fetal Blood - cytology</subject><subject>Fibroblast Growth Factor 2 - cerebrospinal fluid</subject><subject>Humans</subject><subject>Leukocytes, Mononuclear - transplantation</subject><subject>Male</subject><subject>Nerve Growth Factor - cerebrospinal fluid</subject><subject>Treatment Outcome</subject><subject>Vascular Endothelial Growth Factor A - cerebrospinal fluid</subject><issn>1676-5680</issn><issn>1676-5680</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtvFiEUhonR2Iuu3RmWbr6v58DAzCxN461p4qauCcOAxTAwAtOm_8MfLJNW49LVOSHP85KTl5A3CMeO8eGCAYrj1RYejhyPDJ-RU5S9PAg5wPN_9hNyVsoPACa6AV6SEyZ5JwboTsmvm6xjWYOOVVefIk2Obsvkgzc6UJPyTKeQ0kyXFFPcTLA6U2NDKNRHk60uttBg72x7aGq0-c7S7znd11vqtKkpN47WW9ukbKecyupjS3Zh8_NurO1bG2uh974pequ-LK_IC6dDsa-f5jn59vHDzeXnw_XXT18u318fDO-xHsZOokQzgh5ntNq1qTlHZhCwG4bB4egm6HXf9wzAwcjFDGYeJgczCKf5OXn3mLvm9HOzparFl_04HW3aisKeMZSCMfgPFEGKTsi-oRePqGnXlmydWrNfdH5QCGpvTe2tqb01xVExbMbbp_BtWuz8l_9TE_8NDamWRw</recordid><startdate>20150731</startdate><enddate>20150731</enddate><creator>Li, Q</creator><creator>Chen, C-F</creator><creator>Wang, D-Y</creator><creator>Lü, Y-T</creator><creator>Huan, Y</creator><creator>Liu, M</creator><creator>Ge, R-C</creator><creator>Chen, X-W</creator><creator>Qi, H-S</creator><creator>An, L</creator><creator>Hu, X</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20150731</creationdate><title>Transplantation of umbilical cord blood mononuclear cells increases levels of nerve growth factor in the cerebrospinal fluid of patients with autism</title><author>Li, Q ; Chen, C-F ; Wang, D-Y ; Lü, Y-T ; Huan, Y ; Liu, M ; Ge, R-C ; Chen, X-W ; Qi, H-S ; An, L ; Hu, X</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-946161c90a9d1eaf0a9a3312c1014888f19fb07a777200f0935d0cd8bf0d05fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Autistic Disorder - cerebrospinal fluid</topic><topic>Autistic Disorder - therapy</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Fetal Blood - cytology</topic><topic>Fibroblast Growth Factor 2 - cerebrospinal fluid</topic><topic>Humans</topic><topic>Leukocytes, Mononuclear - transplantation</topic><topic>Male</topic><topic>Nerve Growth Factor - cerebrospinal fluid</topic><topic>Treatment Outcome</topic><topic>Vascular Endothelial Growth Factor A - cerebrospinal fluid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Q</creatorcontrib><creatorcontrib>Chen, C-F</creatorcontrib><creatorcontrib>Wang, D-Y</creatorcontrib><creatorcontrib>Lü, Y-T</creatorcontrib><creatorcontrib>Huan, Y</creatorcontrib><creatorcontrib>Liu, M</creatorcontrib><creatorcontrib>Ge, R-C</creatorcontrib><creatorcontrib>Chen, X-W</creatorcontrib><creatorcontrib>Qi, H-S</creatorcontrib><creatorcontrib>An, L</creatorcontrib><creatorcontrib>Hu, X</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Genetics and molecular research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Q</au><au>Chen, C-F</au><au>Wang, D-Y</au><au>Lü, Y-T</au><au>Huan, Y</au><au>Liu, M</au><au>Ge, R-C</au><au>Chen, X-W</au><au>Qi, H-S</au><au>An, L</au><au>Hu, X</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transplantation of umbilical cord blood mononuclear cells increases levels of nerve growth factor in the cerebrospinal fluid of patients with autism</atitle><jtitle>Genetics and molecular research</jtitle><addtitle>Genet Mol Res</addtitle><date>2015-07-31</date><risdate>2015</risdate><volume>14</volume><issue>3</issue><spage>8725</spage><epage>8732</epage><pages>8725-8732</pages><issn>1676-5680</issn><eissn>1676-5680</eissn><abstract>We aimed to evaluate the levels of growth factors in the cerebrospinal fluid (CSF) of patients with autism after transplantation of umbilical cord blood mononuclear cells (CBMNCs). Fourteen subjects diagnosed with autism received transplantation of CBMNCs first through intravenous infusion, and three times subsequently through intrathecal injections. A 2-mL sample of CSF was taken before each intrathecal injection. CSF levels of nerve growth factor (NGF), vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (bFGF) were determined by enzyme-linked immunosorbent assay. All data are reported as means ± SD and were analyzed using the SPSS 10.0 software. One-way analysis of variance with post-hoc F-and Q-tests were performed for comparisons. NGF levels in the CSF were significantly increased after transplantation (213.54 ± 56.38 after the third versus 28.32 ± 12.22 ng/L after the first transplantation; P < 0.05), while VEGF and bFGF levels did not change significantly. Therefore, transplantation of CBMNCs could increase NGF levels in the CSF of patients with autism.</abstract><cop>Brazil</cop><pmid>26345804</pmid><doi>10.4238/2015.July.31.21</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Autistic Disorder - cerebrospinal fluid Autistic Disorder - therapy Child Child, Preschool Female Fetal Blood - cytology Fibroblast Growth Factor 2 - cerebrospinal fluid Humans Leukocytes, Mononuclear - transplantation Male Nerve Growth Factor - cerebrospinal fluid Treatment Outcome Vascular Endothelial Growth Factor A - cerebrospinal fluid |
| title | Transplantation of umbilical cord blood mononuclear cells increases levels of nerve growth factor in the cerebrospinal fluid of patients with autism |
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