Association between the rs3795879 G/A polymorphism of the SERPINE2 gene and chronic obstructive pulmonary disease: a meta-analysis
The present study aimed to investigate the effects of the rs3795879 polymorphism of the SERPINE2 gene on the development of chronic obstructive pulmonary disease (COPD) based on a systematic meta-analysis. An extensive literature search was performed to retrieve previously published case-control stu...
Gespeichert in:
| Veröffentlicht in: | Genetics and molecular research 2015-07, Vol.14 (3), p.7920-7928 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 7928 |
|---|---|
| container_issue | 3 |
| container_start_page | 7920 |
| container_title | Genetics and molecular research |
| container_volume | 14 |
| creator | Tian, D B Cai, S X Pan, G C Zhang, Y F Xiao, J H |
| description | The present study aimed to investigate the effects of the rs3795879 polymorphism of the SERPINE2 gene on the development of chronic obstructive pulmonary disease (COPD) based on a systematic meta-analysis. An extensive literature search was performed to retrieve previously published case-control studies on the polymorphisms of SERPINE2 in COPD patients. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association between SERPINE2 polymorphisms and risk of developing COPD. A total of 5 studies including 3034 COPD cases and 3068 controls were incorporated in the present meta-analysis. Generally, no significant association was identified between the rs3795879 polymorphism of SERPINE2 and the risk of developing COPD (G allele vs A allele: OR = 1.23, 95%CI = 0.97-1.32; GG vs GA: OR = 1.19, 95%CI = 0.81-1.76; GG vs AA: OR = 1.23, 95%CI = 0.89-1.70; dominant model: OR = 1.18, 95%CI = 0.85- 1.62; recessive model: OR = 1.19, 95%CI = 0.85-1.66). In addition, subgroup analyses according to different ethnicities and the source of controls suggest no statistically significant association between the rs3795879 polymorphism of SERPINE2 and COPD risk. The results suggest that the rs3795879 polymorphism of SERPINE2 is not a risk factor for COPD. |
| doi_str_mv | 10.4238/2015.July.14.18 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1722163898</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1722163898</sourcerecordid><originalsourceid>FETCH-LOGICAL-c371t-5967c330289ec36a5884b0ccc816d2e750f2628fa6b270c4ae17c8e2141c1f703</originalsourceid><addsrcrecordid>eNqNkc1v1DAQR62qiJbCuTfkI5fseuzEdnpbVdtSVAHi42w53gnrKomDJ2m1V_5ydmlBHHuaOTw96afH2DmIRSmVXUoB1eLD3O0WUC7AHrFT0EYXlbbi-L__hL0iuhNCVqUVL9mJ1BLK0qhT9mtFlEL0U0wDb3B6QBz4tEWeSZm6sqbm18sVH1O361Met5F6nto_xNf1l883H9eS_8ABuR82PGxzGmLgqaEpz2GK98jHuevT4POObyKhJ7zgnvc4-cIPvttRpNfsRes7wjdP94x9v1p_u3xf3H66vrlc3RZBGZiKqtYmKCWkrTEo7Stry0aEECzojURTiXY_y7ZeN9KIUHoEEyzuh0KA1gh1xt49esecfs5Ik-sjBew6P2CayYGRErSytX0GKgQIDZXao8tHNORElLF1Y479fq8D4Q6N3KGROzRyUDo4yN8-yeemx80__m8U9RuuuYxP</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1700106153</pqid></control><display><type>article</type><title>Association between the rs3795879 G/A polymorphism of the SERPINE2 gene and chronic obstructive pulmonary disease: a meta-analysis</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Tian, D B ; Cai, S X ; Pan, G C ; Zhang, Y F ; Xiao, J H</creator><creatorcontrib>Tian, D B ; Cai, S X ; Pan, G C ; Zhang, Y F ; Xiao, J H</creatorcontrib><description>The present study aimed to investigate the effects of the rs3795879 polymorphism of the SERPINE2 gene on the development of chronic obstructive pulmonary disease (COPD) based on a systematic meta-analysis. An extensive literature search was performed to retrieve previously published case-control studies on the polymorphisms of SERPINE2 in COPD patients. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association between SERPINE2 polymorphisms and risk of developing COPD. A total of 5 studies including 3034 COPD cases and 3068 controls were incorporated in the present meta-analysis. Generally, no significant association was identified between the rs3795879 polymorphism of SERPINE2 and the risk of developing COPD (G allele vs A allele: OR = 1.23, 95%CI = 0.97-1.32; GG vs GA: OR = 1.19, 95%CI = 0.81-1.76; GG vs AA: OR = 1.23, 95%CI = 0.89-1.70; dominant model: OR = 1.18, 95%CI = 0.85- 1.62; recessive model: OR = 1.19, 95%CI = 0.85-1.66). In addition, subgroup analyses according to different ethnicities and the source of controls suggest no statistically significant association between the rs3795879 polymorphism of SERPINE2 and COPD risk. The results suggest that the rs3795879 polymorphism of SERPINE2 is not a risk factor for COPD.</description><identifier>ISSN: 1676-5680</identifier><identifier>EISSN: 1676-5680</identifier><identifier>DOI: 10.4238/2015.July.14.18</identifier><identifier>PMID: 26214473</identifier><language>eng</language><publisher>Brazil</publisher><subject>Confidence Intervals ; Ethnic Groups - genetics ; Genetic Association Studies ; Genetic Heterogeneity ; Genetic Predisposition to Disease ; Humans ; Odds Ratio ; Polymorphism, Single Nucleotide - genetics ; Publication Bias ; Pulmonary Disease, Chronic Obstructive - genetics ; Serpin E2 - genetics</subject><ispartof>Genetics and molecular research, 2015-07, Vol.14 (3), p.7920-7928</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-5967c330289ec36a5884b0ccc816d2e750f2628fa6b270c4ae17c8e2141c1f703</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26214473$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tian, D B</creatorcontrib><creatorcontrib>Cai, S X</creatorcontrib><creatorcontrib>Pan, G C</creatorcontrib><creatorcontrib>Zhang, Y F</creatorcontrib><creatorcontrib>Xiao, J H</creatorcontrib><title>Association between the rs3795879 G/A polymorphism of the SERPINE2 gene and chronic obstructive pulmonary disease: a meta-analysis</title><title>Genetics and molecular research</title><addtitle>Genet Mol Res</addtitle><description>The present study aimed to investigate the effects of the rs3795879 polymorphism of the SERPINE2 gene on the development of chronic obstructive pulmonary disease (COPD) based on a systematic meta-analysis. An extensive literature search was performed to retrieve previously published case-control studies on the polymorphisms of SERPINE2 in COPD patients. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association between SERPINE2 polymorphisms and risk of developing COPD. A total of 5 studies including 3034 COPD cases and 3068 controls were incorporated in the present meta-analysis. Generally, no significant association was identified between the rs3795879 polymorphism of SERPINE2 and the risk of developing COPD (G allele vs A allele: OR = 1.23, 95%CI = 0.97-1.32; GG vs GA: OR = 1.19, 95%CI = 0.81-1.76; GG vs AA: OR = 1.23, 95%CI = 0.89-1.70; dominant model: OR = 1.18, 95%CI = 0.85- 1.62; recessive model: OR = 1.19, 95%CI = 0.85-1.66). In addition, subgroup analyses according to different ethnicities and the source of controls suggest no statistically significant association between the rs3795879 polymorphism of SERPINE2 and COPD risk. The results suggest that the rs3795879 polymorphism of SERPINE2 is not a risk factor for COPD.</description><subject>Confidence Intervals</subject><subject>Ethnic Groups - genetics</subject><subject>Genetic Association Studies</subject><subject>Genetic Heterogeneity</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Odds Ratio</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Publication Bias</subject><subject>Pulmonary Disease, Chronic Obstructive - genetics</subject><subject>Serpin E2 - genetics</subject><issn>1676-5680</issn><issn>1676-5680</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1v1DAQR62qiJbCuTfkI5fseuzEdnpbVdtSVAHi42w53gnrKomDJ2m1V_5ydmlBHHuaOTw96afH2DmIRSmVXUoB1eLD3O0WUC7AHrFT0EYXlbbi-L__hL0iuhNCVqUVL9mJ1BLK0qhT9mtFlEL0U0wDb3B6QBz4tEWeSZm6sqbm18sVH1O361Met5F6nto_xNf1l883H9eS_8ABuR82PGxzGmLgqaEpz2GK98jHuevT4POObyKhJ7zgnvc4-cIPvttRpNfsRes7wjdP94x9v1p_u3xf3H66vrlc3RZBGZiKqtYmKCWkrTEo7Stry0aEECzojURTiXY_y7ZeN9KIUHoEEyzuh0KA1gh1xt49esecfs5Ik-sjBew6P2CayYGRErSytX0GKgQIDZXao8tHNORElLF1Y479fq8D4Q6N3KGROzRyUDo4yN8-yeemx80__m8U9RuuuYxP</recordid><startdate>20150714</startdate><enddate>20150714</enddate><creator>Tian, D B</creator><creator>Cai, S X</creator><creator>Pan, G C</creator><creator>Zhang, Y F</creator><creator>Xiao, J H</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20150714</creationdate><title>Association between the rs3795879 G/A polymorphism of the SERPINE2 gene and chronic obstructive pulmonary disease: a meta-analysis</title><author>Tian, D B ; Cai, S X ; Pan, G C ; Zhang, Y F ; Xiao, J H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-5967c330289ec36a5884b0ccc816d2e750f2628fa6b270c4ae17c8e2141c1f703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Confidence Intervals</topic><topic>Ethnic Groups - genetics</topic><topic>Genetic Association Studies</topic><topic>Genetic Heterogeneity</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Odds Ratio</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Publication Bias</topic><topic>Pulmonary Disease, Chronic Obstructive - genetics</topic><topic>Serpin E2 - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tian, D B</creatorcontrib><creatorcontrib>Cai, S X</creatorcontrib><creatorcontrib>Pan, G C</creatorcontrib><creatorcontrib>Zhang, Y F</creatorcontrib><creatorcontrib>Xiao, J H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Genetics and molecular research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tian, D B</au><au>Cai, S X</au><au>Pan, G C</au><au>Zhang, Y F</au><au>Xiao, J H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between the rs3795879 G/A polymorphism of the SERPINE2 gene and chronic obstructive pulmonary disease: a meta-analysis</atitle><jtitle>Genetics and molecular research</jtitle><addtitle>Genet Mol Res</addtitle><date>2015-07-14</date><risdate>2015</risdate><volume>14</volume><issue>3</issue><spage>7920</spage><epage>7928</epage><pages>7920-7928</pages><issn>1676-5680</issn><eissn>1676-5680</eissn><abstract>The present study aimed to investigate the effects of the rs3795879 polymorphism of the SERPINE2 gene on the development of chronic obstructive pulmonary disease (COPD) based on a systematic meta-analysis. An extensive literature search was performed to retrieve previously published case-control studies on the polymorphisms of SERPINE2 in COPD patients. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association between SERPINE2 polymorphisms and risk of developing COPD. A total of 5 studies including 3034 COPD cases and 3068 controls were incorporated in the present meta-analysis. Generally, no significant association was identified between the rs3795879 polymorphism of SERPINE2 and the risk of developing COPD (G allele vs A allele: OR = 1.23, 95%CI = 0.97-1.32; GG vs GA: OR = 1.19, 95%CI = 0.81-1.76; GG vs AA: OR = 1.23, 95%CI = 0.89-1.70; dominant model: OR = 1.18, 95%CI = 0.85- 1.62; recessive model: OR = 1.19, 95%CI = 0.85-1.66). In addition, subgroup analyses according to different ethnicities and the source of controls suggest no statistically significant association between the rs3795879 polymorphism of SERPINE2 and COPD risk. The results suggest that the rs3795879 polymorphism of SERPINE2 is not a risk factor for COPD.</abstract><cop>Brazil</cop><pmid>26214473</pmid><doi>10.4238/2015.July.14.18</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1676-5680 |
| ispartof | Genetics and molecular research, 2015-07, Vol.14 (3), p.7920-7928 |
| issn | 1676-5680 1676-5680 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1722163898 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Confidence Intervals Ethnic Groups - genetics Genetic Association Studies Genetic Heterogeneity Genetic Predisposition to Disease Humans Odds Ratio Polymorphism, Single Nucleotide - genetics Publication Bias Pulmonary Disease, Chronic Obstructive - genetics Serpin E2 - genetics |
| title | Association between the rs3795879 G/A polymorphism of the SERPINE2 gene and chronic obstructive pulmonary disease: a meta-analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T03%3A59%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20the%20rs3795879%20G/A%20polymorphism%20of%20the%20SERPINE2%20gene%20and%20chronic%20obstructive%20pulmonary%20disease:%20a%20meta-analysis&rft.jtitle=Genetics%20and%20molecular%20research&rft.au=Tian,%20D%20B&rft.date=2015-07-14&rft.volume=14&rft.issue=3&rft.spage=7920&rft.epage=7928&rft.pages=7920-7928&rft.issn=1676-5680&rft.eissn=1676-5680&rft_id=info:doi/10.4238/2015.July.14.18&rft_dat=%3Cproquest_cross%3E1722163898%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1700106153&rft_id=info:pmid/26214473&rfr_iscdi=true |