Dissociation of Antimicrobial and Hemolytic Activities in Cyclic Peptide Diastereomers by Systematic Alterations in Amphipathicity

We have investigated the role of amphipathicity in a homologous series of head-to-tail cyclic antimicrobial peptides in efforts to delineate features resulting in high antimicrobial activity coupled with low hemolytic activity (i.e. a high therapeutic index). The peptide GS14, cyclo(VKLKVd-YPLKVKLd-...

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Veröffentlicht in:	The Journal of biological chemistry 1999-05, Vol.274 (19), p.13181-13192
Hauptverfasser:	Kondejewski, Leslie H., Jelokhani-Niaraki, Masood, Farmer, Susan W., Lix, Bruce, Kay, Cyril M., Sykes, Brian D., Hancock, Robert E.W., Hodges, Robert S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology Candida albicans - drug effects Cell Membrane - metabolism Chromatography, High Pressure Liquid Circular Dichroism Gram-Positive Bacteria - drug effects Hemolysis - drug effects Lipopolysaccharides - metabolism Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Models, Molecular Molecular Sequence Data Peptides, Cyclic - chemistry Peptides, Cyclic - metabolism Peptides, Cyclic - pharmacology Protein Conformation Stereoisomerism Structure-Activity Relationship
Online-Zugang:	Volltext
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