Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality

Keratinocyte growth factor (KGF) stimulates the proliferation and differentiation of epithelial cells including those of the gastrointestinal tract. Although chemotherapeutics and radiation exposure kill rapidly proliferating tumor cells, rapidly dividing normal cells of the host's gastrointest...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1998-03, Vol.58 (5), p.933-939
Hauptverfasser:	FARRELL, C. L, BREADY, J. V, HAVILL, A. M, LU, Z.-N, AUKERMAN, S. L, PIERCE, G. F, THOMASON, A, POTTEN, C. S, ULICH, T. R, LACEY, D. L, REX, K. L, CHEN, J. N, DIPALMA, C. R, WHITCOMB, K. L, SONGMEI YIN, HILL, D. C, WIEMANN, B, STARNES, C. O
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - adverse effects Biological and medical sciences Digestive system Female Fibroblast Growth Factor 10 Fibroblast Growth Factor 7 Fibroblast Growth Factors Growth Substances - administration & dosage Growth Substances - therapeutic use Humans Intestinal Diseases - prevention & control Intestinal Mucosa - drug effects Intestinal Mucosa - injuries Medical sciences Mice Mice, Nude Neoplasms, Experimental - drug therapy Neoplasms, Experimental - mortality Neoplasms, Experimental - radiotherapy Pharmacology. Drug treatments Radiation Injuries, Experimental - prevention & control Recombinant Proteins - pharmacology Recombinant Proteins - therapeutic use Survival Analysis
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