AA-type amyloidosis secondary to multidrug resistant pulmonary tuberculosis: implications for therapy
Multidrug resistant pulmonary tuberculosis was diagnosed to a 32-year-old man. An AA-amyloidosis was subsequently diagnosed on the renal biopsy performed for nephrotic syndrome and macroscopic hematuria. A 6-drug antibiotic treatment was delivered quickly after first results of genotypic antibiogram...
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| Veröffentlicht in: | Revue de pneumologie clinique 2015-10, Vol.71 (5), p.297-300 |
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| container_title | Revue de pneumologie clinique |
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| creator | Baux, E Henard, S Alauzet, C Goehringer, F Laurain, C Champigneulle, J Vaillant, P Hardy, A Rabaud, C May, T |
| description | Multidrug resistant pulmonary tuberculosis was diagnosed to a 32-year-old man. An AA-amyloidosis was subsequently diagnosed on the renal biopsy performed for nephrotic syndrome and macroscopic hematuria. A 6-drug antibiotic treatment was delivered quickly after first results of genotypic antibiogram given the renal failure, and was secondarily adapted to the phenotypic antibiogram. Multidrug therapy was fairly well tolerated. Clinical and biological improving were slow. Although tuberculosis is a classic cause of amyloidosis, this is the first case reporting an association between a multidrug resistant case and an amyloidosis in adults. This case also raises the question of MDR probabilistic treatments in situations whether a vital organ prognosis is engaged. |
| doi_str_mv | 10.1016/j.pneumo.2015.01.001 |
| format | Article |
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An AA-amyloidosis was subsequently diagnosed on the renal biopsy performed for nephrotic syndrome and macroscopic hematuria. A 6-drug antibiotic treatment was delivered quickly after first results of genotypic antibiogram given the renal failure, and was secondarily adapted to the phenotypic antibiogram. Multidrug therapy was fairly well tolerated. Clinical and biological improving were slow. Although tuberculosis is a classic cause of amyloidosis, this is the first case reporting an association between a multidrug resistant case and an amyloidosis in adults. 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| fulltext | fulltext |
| identifier | ISSN: 0761-8417 |
| ispartof | Revue de pneumologie clinique, 2015-10, Vol.71 (5), p.297-300 |
| issn | 0761-8417 |
| language | fre |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Amyloidosis - etiology Antitubercular Agents - therapeutic use Drug Therapy, Combination Humans Male Tuberculosis, Multidrug-Resistant - complications Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Pulmonary - complications Tuberculosis, Pulmonary - drug therapy |
| title | AA-type amyloidosis secondary to multidrug resistant pulmonary tuberculosis: implications for therapy |
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