Effect of glutamate and extracellular calcium on uptake of inorganic lead (Pb 2+) in immortalized mouse hypothalamic GT1–7 neuronal cells

We have previously shown that although glutamate alone has no effects on viability of mouse hypothalamic GT1–7 cells, it clearly enhances Pb 2+-induced cytotoxicity. It is likely that Pb 2+ must enter cells to exert most of its toxic effects. Pb 2+ is known to substitute for Ca 2+ in many cellular p...

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