A Zinc Finger Truncation of Murine WT1 Results in the Characteristic Urogenital Abnormalities of Denys-Drash Syndrome

The Wilms tumor-suppressor gene, WT1, plays a key role in urogenital development, and WT1 dysfunction is implicated in both neoplastic (Wilms tumor, mesothelioma, leukemias, and breast cancer) and nonneoplastic (glomerulosclerosis) disease. The analysis of diseases linked specifically with WT1 mutat...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1999-03, Vol.96 (6), p.2931-2936
Hauptverfasser:	Patek, Charles E., Little, Melissa H., Fleming, Stewart, Miles, Colin, Charlieu, Jean-Paul, Clarke, Alan R., Miyagawa, Kiyoshi, Christie, Sheila, Doig, Jennifer, Harrison, David J., Porteous, David J., Brookes, Anthony J., Hooper, Martin L., Hastie, Nicholas D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biological Sciences Cell lines Chimeras Disease DNA-Binding Proteins - genetics Exons Genes Genes, Wilms Tumor Genetic Linkage Genetic mutation Genetics Genitalia, Male - abnormalities Heterozygotes Humans Kidney Diseases - genetics Kidneys Male Mice Molecular Sequence Data Mutation Nephrons Sertoli cells Sex chromosomes Syndrome Transcription Factors - genetics Tumors Wilms tumors WT1 Proteins Zinc Zinc Fingers - genetics
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