Small heat shock proteins inhibit amyloid-β protein aggregation and cerebrovascular amyloid-β protein toxicity

Small heat shock proteins Hsp20 and HspB2/B3 co-localize with Aβ deposition in senile plaques and cerebral amyloid angiopathy in Alzheimer's disease brains, respectively. It was the aim of our study to investigate if these and other sHsps bind to wild-type Aβ1–42 or the more toxic Aβ1–40 carryi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Brain research 2006-05, Vol.1089 (1), p.67-78
Hauptverfasser:	Wilhelmus, Micha M.M., Boelens, Wilbert C., Otte-Höller, Irene, Kamps, Bram, de Waal, Robert M.W., Verbeek, Marcel M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies alpha-Crystallins - metabolism alpha-Crystallins - pharmacology Alzheimer Disease - metabolism Alzheimer Disease - physiopathology Alzheimer's disease Amyloid beta-Peptides - antagonists & inhibitors Amyloid beta-Peptides - chemistry Amyloid beta-Peptides - genetics Amyloid beta-Peptides - metabolism Amyloid-β protein Biological and medical sciences Cells, Cultured Cerebral Amyloid Angiopathy - metabolism Cerebral Amyloid Angiopathy - physiopathology Cerebral Arteries - metabolism Cerebral Arteries - physiopathology Cerebrovascular amyloid Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Fibrillization Heat-Shock Proteins - metabolism Heat-Shock Proteins - pharmacology HSP20 Heat-Shock Proteins - metabolism HSP20 Heat-Shock Proteins - pharmacology HSP27 Heat-Shock Proteins Humans Medical sciences Mutation - genetics Neoplasm Proteins - metabolism Neoplasm Proteins - pharmacology Neurology Neuroprotective Agents - metabolism Neuroprotective Agents - pharmacology Organic mental disorders. Neuropsychology Peptide Fragments - antagonists & inhibitors Peptide Fragments - genetics Peptide Fragments - metabolism Plaque, Amyloid - metabolism Plaque, Amyloid - pathology Protein Binding - genetics Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Small heat shock protein
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!