Ethanol tolerance and synaptic plasticity

Current concepts of the mechanisms underlying many of the pharmacological effects of ethanol on the CNS involve disruption of ion channel function via the interaction of ethanol with specific hydrophobic sites on channel subunit proteins. Of particular clinical importance is the development of toler...

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Veröffentlicht in:	Trends in pharmacological sciences (Regular ed.) 1998-12, Vol.19 (12), p.491-495
Hauptverfasser:	Chandler, L.Judson, Harris, R.Adron, Crews, Fulton T
Format:	Artikel
Sprache:	eng
Schlagworte:	alcohol Cytoskeletal Proteins - drug effects Drug Tolerance - physiology ethanol Ethanol - pharmacology GABAa receptors NMDA receptors Phosphorylation Receptors, GABA-A - drug effects Receptors, N-Methyl-D-Aspartate - drug effects Receptors, Neurotransmitter - drug effects Substance-Related Disorders - etiology synaptic plasticity Time Factors tolerance
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