Increasing glycolytic flux in Torulopsis glabrata by redirecting ATP production from oxidative phosphorylation to substrate-level phosphorylation

This study aimed at further increasing the pyruvate productivity of a multi-vitamin auxotrophic yeast Torulopsis glabrata by redirecting ATP production from oxidative phosphorylation to substrate-level phosphorylation. We examined two strategies to decrease the activity of F₀F₁-ATPase. The strategie...

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Veröffentlicht in:	Journal of applied microbiology 2006-05, Vol.100 (5), p.1043-1053
Hauptverfasser:	Liu, L.M, Li, Y, Du, G.C, Chen, J
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine triphosphate Adenosine Triphosphate - biosynthesis Antifungal Agents - pharmacology Biological and medical sciences Candida glabrata Candida glabrata - drug effects Candida glabrata - genetics Candida glabrata - growth & development Candida glabrata - metabolism Culture Media Dose-Response Relationship, Drug Drug Resistance, Fungal F0F1‐ATPase Fundamental and applied biological sciences. Psychology glucose glycolysis Glycolysis - drug effects glycolytic flux H-transporting ATP synthase Microbiology Mutagenesis mutants neomycin‐resistant mutant oligomycin Oligomycins - pharmacology Oxidative Phosphorylation phosphofructokinases Phosphorylation pyruvate kinase pyruvic acid screening Torulopsis glabrata yeasts
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