Betulinic Acid and its Derivatives as Potential Antitumor Agents
Betulinic acid (BA) is a lupane‐type pentacyclic triterpene, distributed ubiquitously throughout the plant kingdom. BA and its derivatives demonstrate multiple bioactivities, particularly an antitumor effect. This review critically describes the recent research on isolation, synthesis, and derivatiz...
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Veröffentlicht in: | Medicinal research reviews 2015-11, Vol.35 (6), p.1127-1155 |
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description | Betulinic acid (BA) is a lupane‐type pentacyclic triterpene, distributed ubiquitously throughout the plant kingdom. BA and its derivatives demonstrate multiple bioactivities, particularly an antitumor effect. This review critically describes the recent research on isolation, synthesis, and derivatization of BA and its natural analogs betulin and 23‐hydroxybetulinic acid. The subsequent part of the review focuses on the current knowledge of antitumor properties, combination treatments, and pharmacological mechanisms of these compounds. A 3D‐QSAR analysis of 62 BA derivatives against human ovarian cancer A2780 is also included to provide information concerning the structure–cytotoxicity relationships of these compounds. |
doi_str_mv | 10.1002/med.21353 |
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A 3D‐QSAR analysis of 62 BA derivatives against human ovarian cancer A2780 is also included to provide information concerning the structure–cytotoxicity relationships of these compounds.</description><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>antitumor effect</subject><subject>betulinic acid</subject><subject>Cell Line, Tumor</subject><subject>derivatives</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Humans</subject><subject>Quantitative Structure-Activity Relationship</subject><subject>structure-cytotoxicity relationship</subject><subject>Triterpenes - chemistry</subject><subject>Triterpenes - pharmacology</subject><issn>0198-6325</issn><issn>1098-1128</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtOwzAQRS0EgvJY8AMoEhtYBDx2HDs7yhvEq1UREhvLjR1kSJNiJ0D_HrelLJBYzWh07tHoIrQN-AAwJocjow8IUEaXUAdwJmIAIpZRB0PYU0rYGlr3_hVjAAZ0Fa2RFFMiEt5BR8emaUtb2Tzq5lZHqtKRbXx0apz9UI39MD5SPnqoG1M1VpVRN4ymHdUu6r6Ek99EK4Uqvdn6mRvo8fxscHIZ39xfXJ10b-I8SYHGAheCY44FgywRGjJNWKGGLCM8L7SiBVEC0gJIrnWiCpPkiiXKKEzYkFAt6Abam3vHrn5vjW_kyPrclKWqTN16CXzWAAYe0N0_6Gvduip8N6Uw5RkXEKj9OZW72ntnCjl2dqTcRAKW01plqFXOpIHd-TG2w-l1QS56DMDhHPi0pZn8b5K3Z6cLZTxPWN-Yr9-Ecm8y5ZQz-XR3IXu43xs8D65ln34DnlCOtQ</recordid><startdate>201511</startdate><enddate>201511</enddate><creator>Zhang, Dong-Mei</creator><creator>Xu, Hong-Gui</creator><creator>Wang, Lei</creator><creator>Li, Ying-Jie</creator><creator>Sun, Ping-Hua</creator><creator>Wu, Xiao-Ming</creator><creator>Wang, Guang-Ji</creator><creator>Chen, Wei-Min</creator><creator>Ye, Wen-Cai</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201511</creationdate><title>Betulinic Acid and its Derivatives as Potential Antitumor Agents</title><author>Zhang, Dong-Mei ; Xu, Hong-Gui ; Wang, Lei ; Li, Ying-Jie ; Sun, Ping-Hua ; Wu, Xiao-Ming ; Wang, Guang-Ji ; Chen, Wei-Min ; Ye, Wen-Cai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4613-80f87070851948d19d25fab5927cfda3f2a816f12cdd4afe4ca54aea025b23d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>antitumor effect</topic><topic>betulinic acid</topic><topic>Cell Line, Tumor</topic><topic>derivatives</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Humans</topic><topic>Quantitative Structure-Activity Relationship</topic><topic>structure-cytotoxicity relationship</topic><topic>Triterpenes - chemistry</topic><topic>Triterpenes - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Dong-Mei</creatorcontrib><creatorcontrib>Xu, Hong-Gui</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><creatorcontrib>Li, Ying-Jie</creatorcontrib><creatorcontrib>Sun, Ping-Hua</creatorcontrib><creatorcontrib>Wu, Xiao-Ming</creatorcontrib><creatorcontrib>Wang, Guang-Ji</creatorcontrib><creatorcontrib>Chen, Wei-Min</creatorcontrib><creatorcontrib>Ye, Wen-Cai</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Medicinal research reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Dong-Mei</au><au>Xu, Hong-Gui</au><au>Wang, Lei</au><au>Li, Ying-Jie</au><au>Sun, Ping-Hua</au><au>Wu, Xiao-Ming</au><au>Wang, Guang-Ji</au><au>Chen, Wei-Min</au><au>Ye, Wen-Cai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Betulinic Acid and its Derivatives as Potential Antitumor Agents</atitle><jtitle>Medicinal research reviews</jtitle><addtitle>Med. Res. Rev</addtitle><date>2015-11</date><risdate>2015</risdate><volume>35</volume><issue>6</issue><spage>1127</spage><epage>1155</epage><pages>1127-1155</pages><issn>0198-6325</issn><eissn>1098-1128</eissn><coden>MRREDD</coden><abstract>Betulinic acid (BA) is a lupane‐type pentacyclic triterpene, distributed ubiquitously throughout the plant kingdom. BA and its derivatives demonstrate multiple bioactivities, particularly an antitumor effect. This review critically describes the recent research on isolation, synthesis, and derivatization of BA and its natural analogs betulin and 23‐hydroxybetulinic acid. The subsequent part of the review focuses on the current knowledge of antitumor properties, combination treatments, and pharmacological mechanisms of these compounds. A 3D‐QSAR analysis of 62 BA derivatives against human ovarian cancer A2780 is also included to provide information concerning the structure–cytotoxicity relationships of these compounds.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>26032847</pmid><doi>10.1002/med.21353</doi><tpages>29</tpages></addata></record> |
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subjects | Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology antitumor effect betulinic acid Cell Line, Tumor derivatives Drug Screening Assays, Antitumor Humans Quantitative Structure-Activity Relationship structure-cytotoxicity relationship Triterpenes - chemistry Triterpenes - pharmacology |
title | Betulinic Acid and its Derivatives as Potential Antitumor Agents |
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