Betulinic Acid and its Derivatives as Potential Antitumor Agents

Betulinic acid (BA) is a lupane‐type pentacyclic triterpene, distributed ubiquitously throughout the plant kingdom. BA and its derivatives demonstrate multiple bioactivities, particularly an antitumor effect. This review critically describes the recent research on isolation, synthesis, and derivatiz...

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Veröffentlicht in:Medicinal research reviews 2015-11, Vol.35 (6), p.1127-1155
Hauptverfasser: Zhang, Dong-Mei, Xu, Hong-Gui, Wang, Lei, Li, Ying-Jie, Sun, Ping-Hua, Wu, Xiao-Ming, Wang, Guang-Ji, Chen, Wei-Min, Ye, Wen-Cai
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container_end_page 1155
container_issue 6
container_start_page 1127
container_title Medicinal research reviews
container_volume 35
creator Zhang, Dong-Mei
Xu, Hong-Gui
Wang, Lei
Li, Ying-Jie
Sun, Ping-Hua
Wu, Xiao-Ming
Wang, Guang-Ji
Chen, Wei-Min
Ye, Wen-Cai
description Betulinic acid (BA) is a lupane‐type pentacyclic triterpene, distributed ubiquitously throughout the plant kingdom. BA and its derivatives demonstrate multiple bioactivities, particularly an antitumor effect. This review critically describes the recent research on isolation, synthesis, and derivatization of BA and its natural analogs betulin and 23‐hydroxybetulinic acid. The subsequent part of the review focuses on the current knowledge of antitumor properties, combination treatments, and pharmacological mechanisms of these compounds. A 3D‐QSAR analysis of 62 BA derivatives against human ovarian cancer A2780 is also included to provide information concerning the structure–cytotoxicity relationships of these compounds.
doi_str_mv 10.1002/med.21353
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source MEDLINE; Wiley Online Library Journals Frontfile Complete
subjects Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
antitumor effect
betulinic acid
Cell Line, Tumor
derivatives
Drug Screening Assays, Antitumor
Humans
Quantitative Structure-Activity Relationship
structure-cytotoxicity relationship
Triterpenes - chemistry
Triterpenes - pharmacology
title Betulinic Acid and its Derivatives as Potential Antitumor Agents
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