A Multicenter Trial of Remote Ischemic Preconditioning for Heart Surgery
This multicenter, randomized, controlled trial involving adults undergoing elective cardiac surgery with cardiopulmonary bypass while under propofol anesthesia compared upper-limb remote ischemic preconditioning with a sham intervention. No relevant benefit was observed. Cardiac surgery is associate...
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| Veröffentlicht in: | The New England journal of medicine 2015-10, Vol.373 (15), p.1397-1407 |
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| creator | Meybohm, Patrick Bein, Berthold Brosteanu, Oana Cremer, Jochen Gruenewald, Matthias Stoppe, Christian Coburn, Mark Schaelte, Gereon Böning, Andreas Niemann, Bernd Roesner, Jan Kletzin, Frank Strouhal, Ulrich Reyher, Christian Laufenberg-Feldmann, Rita Ferner, Marion Brandes, Ivo F Bauer, Martin Stehr, Sebastian N Kortgen, Andreas Wittmann, Maria Baumgarten, Georg Meyer-Treschan, Tanja Kienbaum, Peter Heringlake, Matthias Schön, Julika Sander, Michael Treskatsch, Sascha Smul, Thorsten Wolwender, Ewa Schilling, Thomas Fuernau, Georg Hasenclever, Dirk Zacharowski, Kai |
| description | This multicenter, randomized, controlled trial involving adults undergoing elective cardiac surgery with cardiopulmonary bypass while under propofol anesthesia compared upper-limb remote ischemic preconditioning with a sham intervention. No relevant benefit was observed.
Cardiac surgery is associated with a predictable risk of end-organ ischemic and reperfusion injury. Transient ischemia of nonvital tissue, known as remote ischemic preconditioning (RIPC), is reported to help remote vital organs withstand a subsequent prolonged ischemic event.
1
Although proof-of-concept trials suggested that RIPC provides protection against myocardial and kidney injury, as determined by serum cardiac and renal biomarkers, in patients undergoing cardiovascular surgery,
2
–
4
more recent studies failed to show significant differences between the RIPC and control groups with respect to troponin release, inotropic or vasoconstrictor support, renal dysfunction, and lung injury.
5
–
10
Only a few studies have included . . . |
| doi_str_mv | 10.1056/NEJMoa1413579 |
| format | Article |
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Cardiac surgery is associated with a predictable risk of end-organ ischemic and reperfusion injury. Transient ischemia of nonvital tissue, known as remote ischemic preconditioning (RIPC), is reported to help remote vital organs withstand a subsequent prolonged ischemic event.
1
Although proof-of-concept trials suggested that RIPC provides protection against myocardial and kidney injury, as determined by serum cardiac and renal biomarkers, in patients undergoing cardiovascular surgery,
2
–
4
more recent studies failed to show significant differences between the RIPC and control groups with respect to troponin release, inotropic or vasoconstrictor support, renal dysfunction, and lung injury.
5
–
10
Only a few studies have included . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa1413579</identifier><identifier>PMID: 26436208</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Aged ; Anesthesia ; Anesthesia, Intravenous ; Calcium-binding protein ; Cardiac Surgical Procedures ; Cardiology ; Cardiopulmonary Bypass ; Cerebral infarction ; Clinical outcomes ; Clinical trials ; Double-Blind Method ; Elective Surgical Procedures ; Female ; Fibrillation ; Heart ; Heart surgery ; Humans ; Intravenous administration ; Ischemia ; Ischemic Preconditioning - methods ; Kaplan-Meier Estimate ; Length of Stay ; Male ; Mechanical ventilation ; Middle Aged ; Myocardial infarction ; Patients ; Postoperative Complications - prevention & control ; Propofol ; Prospective Studies ; Renal failure ; Reperfusion ; Treatment Failure ; Troponin ; Troponin - blood ; Upper Extremity - blood supply</subject><ispartof>The New England journal of medicine, 2015-10, Vol.373 (15), p.1397-1407</ispartof><rights>Copyright © 2015 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-633c8829e67ed772ac1ab8b857ab9b124def610dcf5e72e0b8afcc15d95890573</citedby><cites>FETCH-LOGICAL-c456t-633c8829e67ed772ac1ab8b857ab9b124def610dcf5e72e0b8afcc15d95890573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa1413579$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1720523347?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,777,781,2746,2747,26084,27905,27906,52363,54045,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26436208$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meybohm, Patrick</creatorcontrib><creatorcontrib>Bein, Berthold</creatorcontrib><creatorcontrib>Brosteanu, Oana</creatorcontrib><creatorcontrib>Cremer, Jochen</creatorcontrib><creatorcontrib>Gruenewald, Matthias</creatorcontrib><creatorcontrib>Stoppe, Christian</creatorcontrib><creatorcontrib>Coburn, Mark</creatorcontrib><creatorcontrib>Schaelte, Gereon</creatorcontrib><creatorcontrib>Böning, Andreas</creatorcontrib><creatorcontrib>Niemann, Bernd</creatorcontrib><creatorcontrib>Roesner, Jan</creatorcontrib><creatorcontrib>Kletzin, Frank</creatorcontrib><creatorcontrib>Strouhal, Ulrich</creatorcontrib><creatorcontrib>Reyher, Christian</creatorcontrib><creatorcontrib>Laufenberg-Feldmann, Rita</creatorcontrib><creatorcontrib>Ferner, Marion</creatorcontrib><creatorcontrib>Brandes, Ivo F</creatorcontrib><creatorcontrib>Bauer, Martin</creatorcontrib><creatorcontrib>Stehr, Sebastian N</creatorcontrib><creatorcontrib>Kortgen, Andreas</creatorcontrib><creatorcontrib>Wittmann, Maria</creatorcontrib><creatorcontrib>Baumgarten, Georg</creatorcontrib><creatorcontrib>Meyer-Treschan, Tanja</creatorcontrib><creatorcontrib>Kienbaum, Peter</creatorcontrib><creatorcontrib>Heringlake, Matthias</creatorcontrib><creatorcontrib>Schön, Julika</creatorcontrib><creatorcontrib>Sander, Michael</creatorcontrib><creatorcontrib>Treskatsch, Sascha</creatorcontrib><creatorcontrib>Smul, Thorsten</creatorcontrib><creatorcontrib>Wolwender, Ewa</creatorcontrib><creatorcontrib>Schilling, Thomas</creatorcontrib><creatorcontrib>Fuernau, Georg</creatorcontrib><creatorcontrib>Hasenclever, Dirk</creatorcontrib><creatorcontrib>Zacharowski, Kai</creatorcontrib><creatorcontrib>RIPHeart Study Collaborators</creatorcontrib><title>A Multicenter Trial of Remote Ischemic Preconditioning for Heart Surgery</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>This multicenter, randomized, controlled trial involving adults undergoing elective cardiac surgery with cardiopulmonary bypass while under propofol anesthesia compared upper-limb remote ischemic preconditioning with a sham intervention. No relevant benefit was observed.
Cardiac surgery is associated with a predictable risk of end-organ ischemic and reperfusion injury. Transient ischemia of nonvital tissue, known as remote ischemic preconditioning (RIPC), is reported to help remote vital organs withstand a subsequent prolonged ischemic event.
1
Although proof-of-concept trials suggested that RIPC provides protection against myocardial and kidney injury, as determined by serum cardiac and renal biomarkers, in patients undergoing cardiovascular surgery,
2
–
4
more recent studies failed to show significant differences between the RIPC and control groups with respect to troponin release, inotropic or vasoconstrictor support, renal dysfunction, and lung injury.
5
–
10
Only a few studies have included . . .</description><subject>Aged</subject><subject>Anesthesia</subject><subject>Anesthesia, Intravenous</subject><subject>Calcium-binding protein</subject><subject>Cardiac Surgical Procedures</subject><subject>Cardiology</subject><subject>Cardiopulmonary Bypass</subject><subject>Cerebral infarction</subject><subject>Clinical outcomes</subject><subject>Clinical trials</subject><subject>Double-Blind Method</subject><subject>Elective Surgical Procedures</subject><subject>Female</subject><subject>Fibrillation</subject><subject>Heart</subject><subject>Heart surgery</subject><subject>Humans</subject><subject>Intravenous administration</subject><subject>Ischemia</subject><subject>Ischemic Preconditioning - methods</subject><subject>Kaplan-Meier Estimate</subject><subject>Length of Stay</subject><subject>Male</subject><subject>Mechanical ventilation</subject><subject>Middle Aged</subject><subject>Myocardial 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Matthias</au><au>Stoppe, Christian</au><au>Coburn, Mark</au><au>Schaelte, Gereon</au><au>Böning, Andreas</au><au>Niemann, Bernd</au><au>Roesner, Jan</au><au>Kletzin, Frank</au><au>Strouhal, Ulrich</au><au>Reyher, Christian</au><au>Laufenberg-Feldmann, Rita</au><au>Ferner, Marion</au><au>Brandes, Ivo F</au><au>Bauer, Martin</au><au>Stehr, Sebastian N</au><au>Kortgen, Andreas</au><au>Wittmann, Maria</au><au>Baumgarten, Georg</au><au>Meyer-Treschan, Tanja</au><au>Kienbaum, Peter</au><au>Heringlake, Matthias</au><au>Schön, Julika</au><au>Sander, Michael</au><au>Treskatsch, Sascha</au><au>Smul, Thorsten</au><au>Wolwender, Ewa</au><au>Schilling, Thomas</au><au>Fuernau, Georg</au><au>Hasenclever, Dirk</au><au>Zacharowski, Kai</au><aucorp>RIPHeart Study Collaborators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Multicenter Trial of Remote Ischemic Preconditioning for Heart Surgery</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2015-10-08</date><risdate>2015</risdate><volume>373</volume><issue>15</issue><spage>1397</spage><epage>1407</epage><pages>1397-1407</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>This multicenter, randomized, controlled trial involving adults undergoing elective cardiac surgery with cardiopulmonary bypass while under propofol anesthesia compared upper-limb remote ischemic preconditioning with a sham intervention. No relevant benefit was observed.
Cardiac surgery is associated with a predictable risk of end-organ ischemic and reperfusion injury. Transient ischemia of nonvital tissue, known as remote ischemic preconditioning (RIPC), is reported to help remote vital organs withstand a subsequent prolonged ischemic event.
1
Although proof-of-concept trials suggested that RIPC provides protection against myocardial and kidney injury, as determined by serum cardiac and renal biomarkers, in patients undergoing cardiovascular surgery,
2
–
4
more recent studies failed to show significant differences between the RIPC and control groups with respect to troponin release, inotropic or vasoconstrictor support, renal dysfunction, and lung injury.
5
–
10
Only a few studies have included . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>26436208</pmid><doi>10.1056/NEJMoa1413579</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2015-10, Vol.373 (15), p.1397-1407 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1721351892 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Aged Anesthesia Anesthesia, Intravenous Calcium-binding protein Cardiac Surgical Procedures Cardiology Cardiopulmonary Bypass Cerebral infarction Clinical outcomes Clinical trials Double-Blind Method Elective Surgical Procedures Female Fibrillation Heart Heart surgery Humans Intravenous administration Ischemia Ischemic Preconditioning - methods Kaplan-Meier Estimate Length of Stay Male Mechanical ventilation Middle Aged Myocardial infarction Patients Postoperative Complications - prevention & control Propofol Prospective Studies Renal failure Reperfusion Treatment Failure Troponin Troponin - blood Upper Extremity - blood supply |
| title | A Multicenter Trial of Remote Ischemic Preconditioning for Heart Surgery |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T18%3A56%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20Multicenter%20Trial%20of%20Remote%20Ischemic%20Preconditioning%20for%20Heart%20Surgery&rft.jtitle=The%20New%20England%20journal%20of%20medicine&rft.au=Meybohm,%20Patrick&rft.aucorp=RIPHeart%20Study%20Collaborators&rft.date=2015-10-08&rft.volume=373&rft.issue=15&rft.spage=1397&rft.epage=1407&rft.pages=1397-1407&rft.issn=0028-4793&rft.eissn=1533-4406&rft_id=info:doi/10.1056/NEJMoa1413579&rft_dat=%3Cproquest_cross%3E3831416441%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1720523347&rft_id=info:pmid/26436208&rfr_iscdi=true |