Selenate specifically sensitizes drug-resistant cancer cells by increasing apoptosis via G2 phase cell cycle arrest without P-GP inhibition

The purpose of this study was to identify conditions that will increase the sensitivity of drug-resistant cancer cells. Selenium derivatives have been shown to present anti-cancer properties in the clinic. Currently, selenate, selenite, selenomethionine (SeMet), methyl-selenocysteine (MSC), and meth...

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Veröffentlicht in:	European journal of pharmacology 2015-10, Vol.764, p.63-69
Hauptverfasser:	Choi, Ae-Ran, Jee Jo, Min, Jung, Myung-Ji, Sik Kim, Hyung, Yoon, Sungpil
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis - drug effects ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors Cell Line, Tumor Drug Resistance, Neoplasm - drug effects Drug-resistance G2 Phase Cell Cycle Checkpoints - drug effects G2-arrest Humans KB Cells P-gp Selenic Acid - pharmacology Selenite Selenium-related drugs
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