Renoprotective effects of berberine through regulation of the MMPs/TIMPs system in streptozocin-induced diabetic nephropathy in rats

Berberine has proven protective effects on diabetic nephropathy, but the mechanism for its effects has not been comprehensively established. Hence, we aimed to explore the renoprotective mechanism of berberine on the accumulation of extracellular matrix, alterations of its major components and corre...

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Veröffentlicht in:	European journal of pharmacology 2015-10, Vol.764, p.448-456
Hauptverfasser:	Ni, Wei-Jian, Ding, Hai-Hua, Zhou, Hong, Qiu, Yuan-Ye, Tang, Li-Qin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Berberine Berberine - pharmacology Blood Glucose - drug effects Blood Glucose - metabolism Blotting, Western Collagen Type IV - metabolism Cytoprotection Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - enzymology Diabetic Nephropathies - chemically induced Diabetic Nephropathies - enzymology Diabetic Nephropathies - pathology Diabetic Nephropathies - prevention & control Diabetic nephropathy Dose-Response Relationship, Drug ECM Fibronectins - metabolism Fibrosis Immunohistochemistry Kidney - drug effects Kidney - enzymology Kidney - pathology Male Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Matrix Metalloproteinases - metabolism MMPs/TIMPs system Rats, Sprague-Dawley Renal fibrosis Signal Transduction - drug effects Streptozocin Time Factors Tissue Inhibitor of Metalloproteinase-1 - metabolism Tissue Inhibitor of Metalloproteinase-2 - metabolism Tissue Inhibitor of Metalloproteinases - metabolism Transforming Growth Factor beta1 - metabolism
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